Search Results - "Iida, Reiko"

Knockout of M-LP/Mpv17L, a newly identified atypical PDE, alleviates diabetic conditions in mice by Iida, Reiko, Ueki, Misuzu, Yasuda, Toshihiro

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Evaluation of the functional effects of genetic variants‒missense and nonsense SNPs, indels and copy number variations‒in the gene encoding human deoxyribonuclease I potentially implicated in autoimmunity by Ueki, Misuzu, Kimura-Kataoka, Kaori, Fujihara, Junko, Iida, Reiko, Kawai, Yasuyuki, Kusaka, Akari, Sasaki, Takamitsu, Takeshita, Haruo, Yasuda, Toshihiro

“…Genetic variants, such as single nucleotide polymorphisms (SNPs), in the deoxyribonuclease I (DNase I) gene which remarkably reduce or abolish the activity are…”
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Survey of single-nucleotide polymorphisms in the gene encoding human deoxyribonuclease I-like 2 producing loss of function potentially implicated in the pathogenesis of parakeratosis by Ueki, Misuzu, Takeshita, Haruo, Utsunomiya, Natsuko, Chino, Takanao, Oyama, Noritaka, Hasegawa, Minoru, Kimura-Kataoka, Kaori, Fujihara, Junko, Iida, Reiko, Yasuda, Toshihiro

“…Dysfunction of DNase I-like 2 (DNase 1L2) has been assumed to play a role in the etiology of parakeratosis through incomplete degradation of DNA in the…”
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Low genetic heterogeneity of copy number variations (CNVs) in the genes encoding the human deoxyribonucleases 1-like 3 and II potentially relevant to autoimmunity by Ueki, Misuzu, Fujihara, Junko, Kimura-Kataoka, Kaori, Yamada, Kazuo, Takinami, Yoshikazu, Takeshita, Haruo, Iida, Reiko, Yasuda, Toshihiro

“…Deoxyribonucleases (DNases) might play a role in prevention of autoimmune conditions such as systemic lupus erythematosus through clearance of cell debris…”
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Knockout of Mpv17-Like Protein (M-LPH) Gene in Human Hepatoma Cells Results in Impairment of mtDNA Integrity through Reduction of TFAM, OGG1, and LIG3 at the Protein Levels by Iida, Reiko, Yasuda, Toshihiro, Ueki, Misuzu

“…Human Mpv17-like protein (M-LPH) has been suggested to participate in prevention of mitochondrial dysfunction caused by mitochondrial DNA (mtDNA) damage. To…”
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Analysis of copy number variation in the NEDD4L gene potentially implicated in body height in the Japanese population by Ueki, Misuzu, Takeshita, Haruo, Fujihara, Junko, Kimura-Kataoka, Kaori, Iida, Reiko, Yasuda, Toshihiro

“…•A candidate CNV associated with body height was analyzed by qPCR method.•The accuracy of the results was confirmed with an Agilent 2100 Bioanalyzer.•Analysis…”
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Identification of functional SNPs potentially served as a genetic risk factor for the pathogenesis of parakeratosis in the gene encoding human deoxyribonuclease I-like 2 (DNase 1L2) implicated in terminal differentiation of keratinocytes by Ueki, Misuzu, Takeshita, Haruo, Kimura-Kataoka, Kaori, Fujihara, Junko, Iida, Reiko, Yasuda, Toshihiro

“…In the present study, we evaluated all of the 35 non-synonymous SNPs in the gene encoding DNase I-like 2 (DNase 1L2), implicated in terminal differentiation of…”
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Comparative biochemical properties of vertebrate deoxyribonuclease I by Fujihara, Junko, Yasuda, Toshihiro, Ueki, Misuzu, Iida, Reiko, Takeshita, Haruo

“…Deoxyribonuclease I (DNase I, EC 3.1.21.1) is an endonuclease that preferentially attacks double-stranded DNA in a Ca2+-dependent manner to produce…”
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Evaluation of all non‐synonymous single nucleotide polymorphisms (SNPs) in the genes encoding human deoxyribonuclease I and I‐like 3 as a functional SNP potentially implicated in autoimmunity by Ueki, Misuzu, Kimura‐Kataoka, Kaori, Takeshita, Haruo, Fujihara, Junko, Iida, Reiko, Sano, Rie, Nakajima, Tamiko, Kominato, Yoshihiko, Kawai, Yasuyuki, Yasuda, Toshihiro

“…The objectives of this study were to evaluate all the non‐synonymous single nucleotide polymorphisms (SNPs) in the DNase I and DNase I‐like 3 (1L3) genes…”
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Evaluation of all nonsynonymous single-nucleotide polymorphisms in the gene encoding human deoxyribonuclease I-like 1, possibly implicated in the blocking of endocytosis-mediated foreign gene transfer by Ueki, Misuzu, Kimura-Kataoka, Kaori, Fujihara, Junko, Takeshita, Haruo, Iida, Reiko, Yasuda, Toshihiro

“…Many nonsynonymous single-nucleotide polymorphisms (SNPs) in the human deoxyribonuclease I-like 1 (DNase 1L1) gene, possibly implicated in the blocking of…”
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Identification of the functional alleles of the nonsynonymous single-nucleotide polymorphisms potentially implicated in systemic lupus erythematosus in the human deoxyribonuclease I gene by Kimura-Kataoka, Kaori, Ueki, Misuzu, Takeshita, Haruo, Fujihara, Junko, Iida, Reiko, Kawai, Yasuyuki, Yasuda, Toshihiro

“…In the present study, we have extensively continued our previous investigations of the nonsynonymous single-nucleotide polymorphisms (SNPs) in the human DNase…”
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Simple screening method for copy number variations associated with physical features by Ueki, Misuzu, Takeshita, Haruo, Fujihara, Junko, Kimura-Kataoka, Kaori, Iida, Reiko, Yasuda, Toshihiro

“…Highlights • We developed a simple Q-PCR method for screening of medicolegally useful CNVs. • A chimeric vector, including a single-copy gene and a CNV…”
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Functional Single Nucleotide Polymorphisms (SNPs) in the Genes Encoding the Human Deoxyribonuclease (DNase) Family Potentially Relevant to Autoimmunity by Fujihara, Junko, Ueki, Misuzu, Kimura-Kataoka, Kaori, Iida, Reiko, Takeshita, Haruo, Yasuda, Toshihiro

“…Objective: To continue our previous investigations, we have extensively investigated the function of the 61, 41, and 35 non-synonymous single nucleotide…”
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Caucasian-specific allele in non-synonymous single nucleotide polymorphisms of the gene encoding deoxyribonuclease I-like 3, potentially relevant to autoimmunity, produces an inactive enzyme by Ueki, Misuzu, Takeshita, Haruo, Fujihara, Junko, Iida, Reiko, Yuasa, Isao, Kato, Hideaki, Panduro, Arturo, Nakajima, Tamiko, Kominato, Yoshihiko, Yasuda, Toshihiro

“…Deoxyribonuclease I-like 3 (DNase Il3), a member of human DNase I family, is postulated to be involved in the genesis of autoimmune diseases. In the DNase Il3…”
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Seven nonsynonymous SNPs in the gene encoding human deoxyribonuclease II may serve as a functional SNP potentially implicated in autoimmune dysfunction by Kimura-Kataoka, Kaori, Ueki, Misuzu, Takeshita, Haruo, Fujihara, Junko, Iida, Reiko, Kato, Hideaki, Yasuda, Toshihiro

“…Many nonsynonymous SNPs in the human DNase II gene (DNASE2), potentially relevant to autoimmunity in conditions such as rheumatoid arthritis, have been…”
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Five non-synonymous SNPs in the gene encoding human deoxyribonuclease I-like 2 implicated in terminal differentiation of keratinocytes reduce or abolish its activity by Ueki, Misuzu, Fujihara, Junko, Kimura-Kataoka, Kaori, Takeshita, Haruo, Iida, Reiko, Yasuda, Toshihiro

“…Several non‐synonymous SNPs in the human deoxyribonuclease I‐like 2 (DNase 1L2) gene responsible for DNA degradation during terminal differentiation of…”
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A Novel Transcriptional Repressor, Rhit, Is Involved in Heat-Inducible and Age-Dependent Expression of Mpv17-Like Protein, a Participant in Reactive Oxygen Species Metabolism by Iida, Reiko, Ueki, Misuzu, Yasuda, Toshihiro

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Genetic and expression analysis of SNPs in the human deoxyribonuclease II: SNPs in the promoter region reduce its in vivo activity through decreased promoter activity by Kimura-Kataoka, Kaori, Yasuda, Toshihiro, Fujihara, Junko, Toga, Tomoko, Ono, Rei-Ichiro, Otsuka, Yosuke, Ueki, Misuzu, Iida, Reiko, Sano, Rie, Nakajima, Tamiko, Kominato, Yoshihiko, Kato, Hideaki, Takeshita, Haruo

“…Five SNPs in the human DNase II gene have been reported to be associated with rheumatoid arthritis (RA). Genotype and haplotype analysis of 14 SNPs, nine SNPs…”
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Multiplex single base extension method for simultaneous genotyping of non-synonymous SNP in the three human SOD genes by Iida, Reiko, Tsubota, Etsuko, Takeshita, Haruo, Yasuda, Toshihiro

“…The superoxide dismutases (SOD) are a family of enzymes that function as the first line of antioxidant defense against highly reactive superoxide radicals. In…”
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Simultaneous determination of seven informative Y chromosome SNPs to differentiate East Asian, European, and African populations by Muro, Tomonori, Iida, Reiko, Fujihara, Junko, Yasuda, Toshihiro, Watanabe, Yukina, Imamura, Shinji, Nakamura, Hiroaki, Kimura-Kataoka, Kaori, Yuasa, Isao, Toga, Tomoko, Takeshita, Haruo

“…Abstract Identification of the population origin of an individual is very useful for crime investigators who need to narrow down a suspect based on specimens…”
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