Search Results - "Ihrie, Rebecca A"

Lake-Front Property: A Unique Germinal Niche by the Lateral Ventricles of the Adult Brain by Ihrie, Rebecca A., Álvarez-Buylla, Arturo

“…New neurons and glial cells are generated in an extensive germinal niche adjacent to the walls of the lateral ventricles in the adult brain. The primary…”
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Ube3a Imprinting Impairs Circadian Robustness in Angelman Syndrome Models by Shi, Shu-qun, Bichell, Terry Jo, Ihrie, Rebecca A., Johnson, Carl Hirschie

“…The paternal allele of Ube3a is silenced by imprinting in neurons, and Angelman syndrome (AS) is a disorder arising from a deletion or mutation of the maternal…”
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Cells in the astroglial lineage are neural stem cells by Ihrie, Rebecca A., Alvarez-Buylla, Arturo

“…A common assumption of classical neuroscience was that neurons and glial cells were derived from separate pools of progenitor cells and that, once development…”
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Controlling COR Competence: BCL-6 Regulates Neurogenesis and Tumor Suppression by Chiang, Chin, Ihrie, Rebecca A.

“…In this issue of Cancer Cell, Tiberi and colleagues describe a tumor-suppressor role for BCL6. In the cerebellum, BCL6 is required for the transition from…”
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Non-canonical functions of a mutant TSC2 protein in mitotic division by Chalkley, Mary-Bronwen L, Mersfelder, Rachel B, Sundberg, Maria, Armstrong, Laura C, Sahin, Mustafa, Ihrie, Rebecca A, Ess, Kevin C

“…Tuberous Sclerosis Complex (TSC) is a debilitating developmental disorder characterized by a variety of clinical manifestations. TSC is caused by mutations in…”
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GBMdeconvoluteR accurately infers proportions of neoplastic and immune cell populations from bulk glioblastoma transcriptomics data by Ajaib, Shoaib, Lodha, Disha, Pollock, Steven, Hemmings, Gemma, Finetti, Martina A, Gusnanto, Arief, Chakrabarty, Aruna, Ismail, Azzam, Wilson, Erica, Varn, Frederick S, Hunter, Bethany, Filby, Andrew, Brockman, Asa A, McDonald, David, Verhaak, Roel G W, Ihrie, Rebecca A, Stead, Lucy F

“…Abstract Background Characterizing and quantifying cell types within glioblastoma (GBM) tumors at scale will facilitate a better understanding of the…”
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Head of the Class: OLIG2 and Glioblastoma Phenotype by Leelatian, Nalin, Ihrie, Rebecca A.

“…Genomic mapping has driven the classification of glioblastoma into distinct molecular subclasses, but mechanisms that regulate tumor subclass phenotypes are…”
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DEPDC5 haploinsufficiency drives increased mTORC1 signaling and abnormal morphology in human iPSC-derived cortical neurons by Klofas, Lindsay K., Short, Brittany P., Snow, John P., Sinnaeve, Justine, Rushing, Gabrielle V., Westlake, Grant, Weinstein, Will, Ihrie, Rebecca A., Ess, Kevin C., Carson, Robert P.

“…Mutations in the DEPDC5 gene can cause epilepsy, including forms with and without brain malformations. The goal of this study was to investigate the…”
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Neural stem cell heterogeneity through time and space in the ventricular-subventricular zone by Rushing, Gabrielle, Ihrie, Rebecca A.

“…BACKGROUND： The origin and classification of neural stem cells （NSCs） has been a subject of intense investigation for the past two decades. Efforts to…”
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A Dorsal SHH-Dependent Domain in the V-SVZ Produces Large Numbers of Oligodendroglial Lineage Cells in the Postnatal Brain by Tong, Cheuk Ka, Fuentealba, Luis C., Shah, Jugal K., Lindquist, Robert A., Ihrie, Rebecca A., Guinto, Cristina D., Rodas-Rodriguez, Jose L., Alvarez-Buylla, Arturo

“…Neural stem cells in different locations of the postnatal mouse ventricular-subventricular zone (V-SVZ) generate different subtypes of olfactory bulb (OB)…”
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Glioblastoma Distance From the Subventricular Neural Stem Cell Niche Does Not Correlate With Survival by Mistry, Akshitkumar M, Mummareddy, Nishit, Salwi, Sanjana, Davis, Larry T, Ihrie, Rebecca A

“…To determine the relationship between survival and glioblastoma distance from the ventricular-subventricular neural stem cell niche (VSVZ). 502 pre-operative…”
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Unsupervised machine learning reveals risk stratifying glioblastoma tumor cells by Leelatian, Nalin, Sinnaeve, Justine, Mistry, Akshitkumar M, Barone, Sierra M, Brockman, Asa A, Diggins, Kirsten E, Greenplate, Allison R, Weaver, Kyle D, Thompson, Reid C, Chambless, Lola B, Mobley, Bret C, Ihrie, Rebecca A, Irish, Jonathan M

“…A goal of cancer research is to reveal cell subsets linked to continuous clinical outcomes to generate new therapeutic and biomarker hypotheses. We introduce a…”
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A Chimeric Egfr Protein Reporter Mouse Reveals Egfr Localization and Trafficking In Vivo by Yang, Yu-Ping, Ma, Haiting, Starchenko, Alina, Huh, Won Jae, Li, Wei, Hickman, F. Edward, Zhang, Qin, Franklin, Jeffrey L., Mortlock, Douglas P., Fuhrmann, Sabine, Carter, Bruce D., Ihrie, Rebecca A., Coffey, Robert J.

“…EGF receptor (EGFR) is a critical signaling node throughout life. However, it has not been possible to directly visualize endogenous Egfr in mice. Using…”
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Rescue of impaired blood-brain barrier in tuberous sclerosis complex patient derived neurovascular unit by Brown, Jacquelyn A, Faley, Shannon L, Judge, Monika, Ward, Patricia, Ihrie, Rebecca A, Carson, Robert, Armstrong, Laura, Sahin, Mustafa, Wikswo, John P, Ess, Kevin C, Neely, M Diana

“…Tuberous sclerosis complex (TSC) is a multi-system genetic disease that causes benign tumors in the brain and other vital organs. The most debilitating…”
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Persistent Sonic Hedgehog Signaling in Adult Brain Determines Neural Stem Cell Positional Identity by Ihrie, Rebecca A., Shah, Jugal K., Harwell, Corey C., Levine, Jacob H., Guinto, Cristina D., Lezameta, Melissa, Kriegstein, Arnold R., Alvarez-Buylla, Arturo

“…Neural stem cells (NSCs) persist in the subventricular zone (SVZ) of the adult brain. Location within this germinal region determines the type of neuronal…”
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An immunosuppressed microenvironment distinguishes lateral ventricle-contacting glioblastomas by Bartkowiak, Todd, Lima, Sierra M, Hayes, Madeline J, Mistry, Akshitkumar M, Brockman, Asa A, Sinnaeve, Justine, Leelatian, Nalin, Roe, Caroline E, Mobley, Bret C, Chotai, Silky, Weaver, Kyle D, Thompson, Reid C, Chambless, Lola B, Ihrie, Rebecca A, Irish, Jonathan M

“…Radiographic contact of glioblastoma (GBM) tumors with the lateral ventricle and adjacent stem cell niche correlates with poor patient prognosis, but the…”
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GLI3 Is Required for OLIG2+ Progeny Production in Adult Dorsal Neural Stem Cells by Embalabala, Rebecca J, Brockman, Asa A, Jurewicz, Amanda R, Kong, Jennifer A, Ryan, Kaitlyn, Guinto, Cristina D, Álvarez-Buylla, Arturo, Chiang, Chin, Ihrie, Rebecca A

“…The ventricular-subventricular zone (V-SVZ) is a postnatal germinal niche. It holds a large population of neural stem cells (NSCs) that generate neurons and…”
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PERP regulates enamel formation via effects on cell-cell adhesion and gene expression by Jheon, Andrew H, Mostowfi, Pasha, Snead, Malcolm L, Ihrie, Rebecca A, Sone, Eli, Pramparo, Tiziano, Attardi, Laura D, Klein, Ophir D

“…Little is known about the role of cell-cell adhesion in the development of mineralized tissues. Here we report that PERP, a tetraspan membrane protein…”
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Developmental context determines latency of MYC-induced tumorigenesis by Beer, Shelly, Zetterberg, Anders, Ihrie, Rebecca A, McTaggart, Ryan A, Yang, Qiwei, Bradon, Nicole, Arvanitis, Constadina, Attardi, Laura D, Feng, Sandy, Ruebner, Boris, Cardiff, Robert D, Felsher, Dean W

“…One of the enigmas in tumor biology is that different types of cancers are prevalent in different age groups. One possible explanation is that the ability of a…”
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Unexpected effects of ivermectin and selamectin on inducible CreER activity in mice by Kropp, Peter A., Rushing, Gabrielle V., Brockman, Asa A., Yu, Erin N. Z., Ihrie, Rebecca A., Gannon, Maureen

“…Abstract Background Anti-parasitics are frequently used in research animal facilities to treat a multitude of common infections, with pinworms and fur mites…”
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