Search Results - "Ihara, Makoto"

Neonicotinoid Insecticides: Molecular Targets, Resistance, and Toxicity by Matsuda, Kazuhiko, Ihara, Makoto, Sattelle, David B

“…Neonicotinoids have been used to protect crops and animals from insect pests since the 1990s, but there are concerns regarding their adverse effects on…”
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A dual-target molecular mechanism of pyrethrum repellency against mosquitoes by Liu, Feng, Wang, Qiang, Xu, Peng, Andreazza, Felipe, Valbon, Wilson R., Bandason, Elizabeth, Chen, Mengli, Yan, Ru, Feng, Bo, Smith, Leticia B., Scott, Jeffrey G., Takamatsu, Genki, Ihara, Makoto, Matsuda, Kazuhiko, Klimavicz, James, Coats, Joel, Oliveira, Eugenio E., Du, Yuzhe, Dong, Ke

“…Pyrethrum extracts from flower heads of Chrysanthemum spp. have been used worldwide in insecticides and repellents. While the molecular mechanisms of its…”
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Modes of Action, Resistance and Toxicity of Insecticides Targeting Nicotinic Acetylcholine Receptors by Ihara, Makoto, Buckingham, Steven D, Matsuda, Kazuhiko, Sattelle, David B

“…Nicotinic acetylcholine receptors (nAChRs) of insects play a key role in fast excitatory neurotransmission. Several classes of insecticides target insect…”
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Expression of the DNA-dependent protein kinase catalytic subunit is associated with the radiosensitivity of human thyroid cancer cell lines by Ihara, Makoto, Ashizawa, Kiyoto, Shichijo, Kazuko, Kudo, Takashi

“…Abstract The prognosis and treatment of thyroid cancer depends on the type and stage of the disease. Radiosensitivity differs among cancer cells owing to their…”
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Mechanisms of Action, Resistance and Toxicity of Insecticides Targeting GABA Receptors by Buckingham, Steven D, Ihara, Makoto, Sattelle, David B, Matsuda, Kazuhiko

“…γ-Aminobutyric acid (GABA) receptors play a central role in fast inhibitory neurotransmission in insects. Several classes of insecticides targeting insect…”
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Wortmannin, a specific inhibitor of phosphatidylinositol-3-kinase, induces accumulation of DNA double-strand breaks by Ihara, Makoto, Shichijo, Kazuko, Takeshita, Satoshi, Kudo, Takashi

“…Abstract Wortmannin, a fungal metabolite, is a specific inhibitor of the phosphatidylinositol 3-kinase (PI3K) family, which includes double-stranded DNA…”
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Comparative ecotoxicity of imidacloprid and dinotefuran to aquatic insects in rice mesocosms by Kobashi, Koji, Harada, Takaaki, Adachi, Yoshihiro, Mori, Miho, Ihara, Makoto, Hayasaka, Daisuke

“…There are growing concerns about the impacts of neonicotinoid insecticides on ecosystems worldwide, and yet ecotoxicity of many of these chemicals at community…”
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The mechanism of loop C-neonicotinoid interactions at insect nicotinic acetylcholine receptor α1 subunit predicts resistance emergence in pests by Shimada, Shota, Kamiya, Masaki, Shigetou, Sho, Tomiyama, Kakeru, Komori, Yuma, Magara, Leo, Ihara, Makoto, Matsuda, Kazuhiko

“…Neonicotinoids selectively modulate insect nicotinic acetylcholine receptors (insect nAChRs). Studies have shown that serine with ability to form a hydrogen…”
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STAT3 inhibitory activity of naphthoquinones isolated from Tabebuia avellanedae by Tahara, Teruyuki, Watanabe, Ami, Yutani, Maho, Yamano, Yuko, Sagara, Mami, Nagai, Shizu, Saito, Keita, Yamashita, Mitsuaki, Ihara, Makoto, Iida, Akira

“…[Display omitted] The extract of Tabebuia avellanedae has been used as a folk medicine, and the various biological activities of T. avellanedae have been…”
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Modulation by neonicotinoids of honeybee α1/chicken β2 hybrid nicotinic acetylcholine receptors expressed in Xenopus laevis oocytes by Shigetou, Sho, Shimada, Shota, Makoto, Ihara, Matsuda, Kazuhiko

“…Neonicotinoids targeting insect nicotinic acetylcholine (ACh) receptors (insect nAChRs) are used for crop protection, but there is a concern about adverse…”
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Availability of NHS-biotin labeling to identify free protein lysine revealed by experiment and MD simulation by Muraoka, Aiichiro, Matsuura, Yoshinori, Naitow, Hisashi, Ihara, Makoto, Kunishima, Naoki

“…It is known that the crystallizability of protein molecules may be improved by replacing their surface lysine residues with other residue types. Here an…”
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Functional impact of subunit composition and compensation on Drosophila melanogaster nicotinic receptors-targets of neonicotinoids by Komori, Yuma, Takayama, Koichi, Okamoto, Naoki, Kamiya, Masaki, Koizumi, Wataru, Ihara, Makoto, Misawa, Daitaro, Kamiya, Kotaro, Yoshinari, Yuto, Seike, Kazuki, Kondo, Shu, Tanimoto, Hiromu, Niwa, Ryusuke, Sattelle, David B, Matsuda, Kazuhiko

“…Neonicotinoid insecticides target insect nicotinic acetylcholine receptors (nAChRs) and their adverse effects on non-target insects are of serious concern. We…”
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Identification of multiple odorant receptors essential for pyrethrum repellency in Drosophila melanogaster by Wang, Qiang, Xu, Peng, Andreazza, Felipe, Liu, Yahui, Nomura, Yoshiko, Duran, Phil, Jiang, Lan, Chen, Mengli, Takamatsu, Genki, Ihara, Makoto, Matsuda, Kazuhiko, Isaacs, Rufus, Oliveira, Eugenio E, Du, Yuzhe, Dong, Ke

“…Pyrethrum extract from dry flowers of Tanacetum cinerariifolium (formally Chrysanthemum cinerariifolium ) has been used globally as a popular insect repellent…”
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Action of six pyrethrins purified from the botanical insecticide pyrethrum on cockroach sodium channels expressed in Xenopus oocytes by Chen, Mengli, Du, Yuzhe, Zhu, Guonian, Takamatsu, Genki, Ihara, Makoto, Matsuda, Kazuhiko, Zhorov, Boris S., Dong, Ke

“…Pyrethrin I, pyrethrin II, cinerin I, cinerin II, jasmolin I and jasmolin II are six closely related insecticidal active esters, known as pyrethrins, found in…”
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Reactivation of heat-inactivated Ku proteins by heat shock cognate protein HSC73 by Ihara, Makoto, Shichijo, Kazuko, Kudo, Takashi, Ohtsuka, Kenzo

“…Purpose: Mouse double-stranded DNA-dependent protein kinase (DNA-PK) activity is heat sensitive. Recovery of heat-inactivated DNA repair activity is a problem…”
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Studies on an acetylcholine binding protein identify a basic residue in loop G on the β1 strand as a new structural determinant of neonicotinoid actions by Ihara, Makoto, Okajima, Toshihide, Yamashita, Atsuko, Oda, Takuma, Asano, Takuya, Matsui, Mikana, Sattelle, David B, Matsuda, Kazuhiko

“…Neonicotinoid insecticides target insect nicotinic acetylcholine receptors (nAChRs). Their widespread use and possible risks to pollinators make it extremely…”
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Loops D, E and G in the Drosophila Dα1 subunit contribute to high neonicotinoid sensitivity of Dα1‐chicken β2 nicotinic acetylcholine receptor by Ihara, Makoto, Hikida, Mai, Matsushita, Hiroyuki, Yamanaka, Kyosuke, Kishimoto, Yuya, Kubo, Kazuki, Watanabe, Shun, Sakamoto, Mifumi, Matsui, Koutaro, Yamaguchi, Akihiro, Okuhara, Daiki, Furutani, Shogo, Sattelle, David B, Matsuda, Kazuhiko

“…Background and Purpose Neonicotinoid insecticides interact with the orthosteric site formed at subunit interfaces of insect nicotinic ACh (nACh) receptors…”
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Meroterpenoid Chrodrimanins Are Selective and Potent Blockers of Insect GABA-Gated Chloride Channels by Xu, Yan, Furutani, Shogo, Ihara, Makoto, Ling, Yun, Yang, Xinling, Kai, Kenji, Hayashi, Hideo, Matsuda, Kazuhiko

“…Meroterpenoid chrodrimanins, produced from Talaromyces sp. YO-2, are known to paralyze silkworm (Bombyx mori) larvae, but their target is unknown. We have…”
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Okaramine insecticidal alkaloids show similar activity on both exon 3c and exon 3b variants of glutamate-gated chloride channels of the larval silkworm, Bombyx mori by Furutani, Shogo, Ihara, Makoto, Kai, Kenji, Tanaka, Keiji, Sattelle, David B., Hayashi, Hideo, Matsuda, Kazuhiko

“…•Okaramines were tested on the exon 3c variant of Bombyx glutamate gated chloride channel (GluCl).•The potency of okaramines on the GluCl exon 3c variant was…”
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Probing new components (loop G and the α–α interface) of neonicotinoid binding sites on nicotinic acetylcholine receptors by Ihara, Makoto, Sattelle, David B., Matsuda, Kazuhiko

“…•A novel putative binding site for neonicotinoids is formed by two adjacent α subunits in nicotinic acetylcholine receptors.•Some neonicotinoids interact with…”
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