Search Results - "Igwe, Kay"

Brain Aging Among Racially and Ethnically Diverse Middle-Aged and Older Adults by Turney, Indira C, Lao, Patrick J, Rentería, Miguel Arce, Igwe, Kay C, Berroa, Joncarlos, Rivera, Andres, Benavides, Andrea, Morales, Clarissa D, Rizvi, Batool, Schupf, Nicole, Mayeux, Richard, Manly, Jennifer J, Brickman, Adam M

“…Neuroimaging studies have documented racial and ethnic disparities in brain health in old age. It remains unclear whether these disparities are apparent in…”
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Alzheimer‐Related Cerebrovascular Disease in Down Syndrome by Lao, Patrick J., Gutierrez, José, Keator, David, Rizvi, Batool, Banerjee, Arit, Igwe, Kay C., Laing, Krystal K., Sathishkumar, Mithra, Moni, Fahmida, Andrews, Howard, Krinsky‐McHale, Sharon, Head, Elizabeth, Lee, Joseph H., Lai, Florence, Yassa, Michael A., Rosas, H. Diana, Silverman, Wayne, Lott, Ira T., Schupf, Nicole, Brickman, Adam M.

“…Objective Adults with Down syndrome (DS) develop Alzheimer disease (AD) pathology by their 5th decade. Compared with the general population, traditional…”
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White matter hyperintensities mediate the association of nocturnal blood pressure with cognition by Chesebro, Anthony G., Melgarejo, Jesus D., Leendertz, Reinier, Igwe, Kay C., Lao, Patrick J., Laing, Krystal K., Rizvi, Batool, Budge, Mariana, Meier, Irene B., Calmon, Gustavo, Lee, Joseph H., Maestre, Gladys E., Brickman, Adam M.

“…OBJECTIVETo test the hypotheses that hypertension and nocturnal blood pressure are related to white matter hyperintensity (WMH) volume, an MRI marker of small…”
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Education differentially contributes to cognitive reserve across racial/ethnic groups by Avila, Justina F., Rentería, Miguel Arce, Jones, Richard N., Vonk, Jet M. J., Turney, Indira, Sol, Ketlyne, Seblova, Dominika, Arias, Franchesca, Hill‐Jarrett, Tanisha, Levy, Shellie‐Anne, Meyer, Oanh, Racine, Annie M., Tom, Sarah E., Melrose, Rebecca J., Deters, Kacie, Medina, Luis D., Carrión, Carmen I., Díaz‐Santos, Mirella, Byrd, DeAnnah R., Chesebro, Anthony, Colon, Juliet, Igwe, Kay C., Maas, Benjamin, Brickman, Adam M., Schupf, Nicole, Mayeux, Richard, Manly, Jennifer J.

“…Introduction We examined whether educational attainment differentially contributes to cognitive reserve (CR) across race/ethnicity. Methods A total of 1553…”
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Automatic quantification of white matter hyperintensities on T2-weighted fluid attenuated inversion recovery magnetic resonance imaging by Igwe, Kay C., Lao, Patrick J., Vorburger, Robert S., Banerjee, Arit, Rivera, Andres, Chesebro, Anthony, Laing, Krystal, Manly, Jennifer J., Brickman, Adam M.

“…White matter hyperintensities (WMH) are areas of increased signal visualized on T2-weighted fluid attenuated inversion recovery (FLAIR) brain magnetic…”
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Classifying multiple sclerosis patients on the basis of SDMT performance using machine learning by Buyukturkoglu, Korhan, Zeng, Dana, Bharadwaj, Srinidhi, Tozlu, Ceren, Mormina, Enricomaria, Igwe, Kay C, Lee, Seonjoo, Habeck, Christian, Brickman, Adam M, Riley, Claire S, De Jager, Philip L, Sumowski, James F, Leavitt, Victoria M

“…Objective: To build a model to predict cognitive status reflecting structural, functional, and white matter integrity changes in early multiple sclerosis (MS)…”
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Frailty and Its Correlates in Adults With Late Life Depression by Brown, Patrick J., Roose, Steven P., O'Boyle, Kaleigh R., Ciarleglio, Adam, Maas, Benjamin, Igwe, Kay C., Chung, Sarah, Gomez, Stephanie, Naqvi, Maleeha, Brickman, Adam M., Rutherford, Bret R.

“…•Recent studies have shown an association between the biological syndrome of frailty and late life depression. These studies, however, were primarily…”
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Amyloid, cerebrovascular disease, and neurodegeneration biomarkers are associated with cognitive trajectories in a racially and ethnically diverse, community-based sample by Lao, Patrick J., Boehme, Amelia K., Morales, Clarissa, Laing, Krystal K., Chesebro, Anthony, Igwe, Kay C., Gutierrez, Jose, Gu, Yian, Stern, Yaakov, Schupf, Nicole, Manly, Jennifer J., Mayeux, Richard, Brickman, Adam M.

“…•Greater amyloid was associated with faster memory decline in older adults.•Greater amyloid was associated with faster non–memory decline in older Non-Hispanic…”
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Cerebrovascular Contributions to Neurocognitive Disorders in People Living With HIV by Gutierrez, Jose, Porras, Tiffany N., Yoo-Jeong, Moka, Khasiyev, Farid, Igwe, Kay C., Laing, Krystal K., Brickman, Adam M., Pavol, Marykay, Schnall, Rebecca

“…To investigate a comprehensive array of magnetic resonance imaging (MRI)-based biomarkers of cerebrovascular disease (CVD) in a cohort of people living with…”
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Serum inflammation markers associated with altered brain white matter microstructure in people with HIV on antiretroviral treatment by Spagnolo-Allende, Antonio, Schnall, Rebecca, Liu, Minghua, Igwe, Kay C., Laing, Krystal K., Chesebro, Anthony G., Brickman, Adam M., Gutierrez, Jose

“…Background Many studies have reported reduced brain white matter fractional anisotropy (FA) and increased mean diffusivity (MD) on diffusion tensor imaging…”
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Tract-defined regional white matter hyperintensities and memory by Rizvi, Batool, Lao, Patrick J., Colón, Juliet, Hale, Christiane, Igwe, Kay C., Narkhede, Atul, Budge, Mariana, Manly, Jennifer J., Schupf, Nicole, Brickman, Adam M.

“…•White matter hyperintensity volume in association and projection tracts was related to memory in older adults.•The relationship of WMH volumes in association…”
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White matter hyperintensities are a prominent feature of autosomal dominant Alzheimer's disease that emerge prior to dementia by Schoemaker, Dorothee, Zanon Zotin, Maria Clara, Chen, Kewei, Igwe, Kay C, Vila-Castelar, Clara, Martinez, Jairo, Baena, Ana, Fox-Fuller, Joshua T, Lopera, Francisco, Reiman, Eric M, Brickman, Adam M, Quiroz, Yakeel T

“…To promote the development of effective therapies, there is an important need to characterize the full spectrum of neuropathological changes associated with…”
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Mnemonic Monitoring in Anosognosia for Memory Loss by Chapman, Silvia, Cosentino, Stephanie, Igwe, Kay C., Abdurahman, Ayat, Elkind, Mitchell S. V., Brickman, Adam M., Charlton, Rebecca, Cocchini, Gianna

“…Objective: Anosognosia, or unawareness, for memory loss has been proposed to underlie cognitive functions such as memory and executive function. However, there…”
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Author Response: White Matter Hyperintensities Mediate the Association of Nocturnal Blood Pressure With Cognition by Chesebro, Anthony G., Melgarejo, Jesus D., Leendertz, Reinier, Igwe, Kay C., Lao, Patrick J., Laing, Krystal K., Rizvi, Batool, Budge, Mariana, Meier, Irene B., Calmon, Gustavo, Lee, Joseph H., Maestre, Gladys, Brickman, Adam M.

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Small vessel cerebrovascular disease is associated with cognition in prospective Alzheimer's clinical trial participants by Morales, Clarissa D, Cotton-Samuel, Dejania, Lao, Patrick J, Chang, Julia F, Pyne, Jeffrey D, Alshikho, Mohamad J, Lippert, Rafael V, Bista, Kelsang, Hale, Christiane, Edwards, Natalie C, Igwe, Kay C, Deters, Kacie, Zimmerman, Molly E, Brickman, Adam M

“…Secondary prevention clinical trials for Alzheimer's disease (AD) target amyloid accumulation in asymptomatic, amyloid-positive individuals, but it is unclear…”
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Probing the proteome to explore potential correlates of increased Alzheimer's‐related cerebrovascular disease in adults with Down syndrome by Moni, Fahmida, Petersen, Melissa E., Zhang, Fan, Lao, Patrick J., Zimmerman, Molly E., Gu, Yian, Gutierrez, José, Rizvi, Batool, Laing, Krystal K., Igwe, Kay C., Sathishkumar, Mithra, Keator, David, Andrews, Howard, Krinsky‐McHale, Sharon, Head, Elizabeth, Lee, Joseph H., Lai, Florence, Yassa, Michael A., Rosas, H. Diana, Silverman, Wayne, Lott, Ira T., Schupf, Nicole, O'Bryant, Sid, Brickman, Adam M.

“…Cerebrovascular disease is associated with symptoms and pathogenesis of Alzheimer's disease (AD) among adults with Down syndrome (DS). The cause of increased…”
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Reduced Hippocampal GABA+ Is Associated With Poorer Episodic Memory in Healthy Older Women: A Pilot Study by Jiménez-Balado, Joan, Ycaza Herrera, Alexandra, Igwe, Kay, Klem, Lynda, Buyukturkoglu, Korhan, Irimia, Andrei, Chen, Liu, Guo, Jia, Brickman, Adam M, Eich, Teal S

“…: The current pilot study was designed to examine the association between hippocampal γ-aminobutyric acid (GABA) concentration and episodic memory in older…”
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Cerebrovascular disease promotes tau pathology in Alzheimer’s disease by Laing, Krystal K, Simoes, Sabrina, Baena-Caldas, Gloria P, Lao, Patrick J, Kothiya, Milankumar, Igwe, Kay C, Chesebro, Anthony G, Houck, Alexander L, Pedraza, Lina, Hernández, A Iván, Li, Jie, Zimmerman, Molly E, Luchsinger, José A, Barone, Frank C, Moreno, Herman, Brickman, Adam M

“…Abstract Small vessel cerebrovascular disease, visualized as white matter hyperintensities on T2-weighted magnetic resonance imaging, contributes to the…”
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White Matter Regions With Low Microstructure in Young Adults Spatially Coincide With White Matter Hyperintensities in Older Adults by Lao, Patrick J, Vorburger, Robert S, Narkhede, Atul, Gazes, Yunglin, Igwe, Kay C, Colón, Juliet, Amarante, Erica, Guzman, Vanessa A, Last, Briana S, Habeck, Christian, Stern, Yaakov, Brickman, Adam M

“…Microstructural and macrostructural white matter damage occurs frequently with aging, is associated with negative health outcomes, and can be imaged…”
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Association of brain arterial diameters with demographic and anatomical factors in a multi-national pooled analysis of cohort studies by Del Brutto, Victor J, Khasiyev, Farid, Liu, Minghua, Spagnolo-Allende, Antonio, Qiao, Ye, Melgarejo Arias, Jesus D, Guzman, Vanessa A, Igwe, Kay C, Sanchez, Danurys L, Andrews, Howard, Morales, Clarissa D, Farrell, Meagan T, Bassil, Darina T, Seshadri, Sudha, Wagner, Ryan G, Mngomezulu, Victor, Manly, Jennifer, Elkind, Mitchell SV, Berkman, Lisa, Romero, Jose R, Maestre, Gladys E, Del Brutto, Oscar H, Brickman, Adam M, Venketasubramanian, Narayanaswamy, Chen, Christopher, Robert, Caroline, Hilal, Saima, Rundek, Tatjana, Wasserman, Bruce A, Gutierrez, Jose

“…Background and Purpose Brain arterial diameters are markers of cerebrovascular disease. Demographic and anatomical factors may influence arterial diameters. We…”
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