Search Results - "Igolkina, Anna A."

Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment by Kfoury, Youmna, Baryawno, Ninib, Severe, Nicolas, Mei, Shenglin, Gustafsson, Karin, Hirz, Taghreed, Brouse, Thomas, Scadden, Elizabeth W., Igolkina, Anna A., Kokkaliaris, Konstantinos, Choi, Bryan D., Barkas, Nikolas, Randolph, Mark A., Shin, John H., Saylor, Philip J., Scadden, David T., Sykes, David B., Kharchenko, Peter V.

“…Bone metastases are devastating complications of cancer. They are particularly common in prostate cancer (PCa), represent incurable disease, and are refractory…”
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Heterogeneity of the GFP fitness landscape and data-driven protein design by Gonzalez Somermeyer, Louisa, Fleiss, Aubin, Mishin, Alexander S, Bozhanova, Nina G, Igolkina, Anna A, Meiler, Jens, Alaball Pujol, Maria-Elisenda, Putintseva, Ekaterina V, Sarkisyan, Karen S, Kondrashov, Fyodor A

“…Studies of protein fitness landscapes reveal biophysical constraints guiding protein evolution and empower prediction of functional proteins. However,…”
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Microevolution, speciation and macroevolution in rhizobia: Genomic mechanisms and selective patterns by Provorov, Nikolay A., Andronov, Evgeny E., Kimeklis, Anastasiia K., Onishchuk, Olga P., Igolkina, Anna A., Karasev, Evgeny S.

“…Nodule bacteria (rhizobia), N 2 -fixing symbionts of leguminous plants, represent an excellent model to study the fundamental issues of evolutionary biology,…”
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Multi-trait multi-locus SEM model discriminates SNPs of different effects by Igolkina, Anna A, Meshcheryakov, Georgy, Gretsova, Maria V, Nuzhdin, Sergey V, Samsonova, Maria G

“…There is a plethora of methods for genome-wide association studies. However, only a few of them may be classified as multi-trait and multi-locus, i.e. consider…”
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H3K4me3, H3K9ac, H3K27ac, H3K27me3 and H3K9me3 Histone Tags Suggest Distinct Regulatory Evolution of Open and Condensed Chromatin Landmarks by Igolkina, Anna A, Zinkevich, Arsenii, Karandasheva, Kristina O, Popov, Aleksey A, Selifanova, Maria V, Nikolaeva, Daria, Tkachev, Victor, Penzar, Dmitry, Nikitin, Daniil M, Buzdin, Anton

“…Transposons are selfish genetic elements that self-reproduce in host DNA. They were active during evolutionary history and now occupy almost half of mammalian…”
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Be aware of the allele-specific bias and compositional effects in multi-template PCR by Korvigo, Ilia, Igolkina, Anna A, Kichko, Arina A, Aksenova, Tatiana, Andronov, Evgeny E

“…High-throughput sequencing of amplicon libraries is the most widespread and one of the most effective ways to study the taxonomic structure of microbial…”
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Genomic Analysis of Vavilov's Historic Chickpea Landraces Reveals Footprints of Environmental and Human Selection by Sokolkova, Alena, Bulyntsev, Sergey V, Chang, Peter L, Carrasquilla-Garcia, Noelia, Igolkina, Anna A, Noujdina, Nina V, von Wettberg, Eric, Vishnyakova, Margarita A, Cook, Douglas R, Nuzhdin, Sergey V, Samsonova, Maria G

“…A defining challenge of the 21st century is meeting the nutritional demands of the growing human population, under a scenario of limited land and water…”
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Towards Understanding Afghanistan Pea Symbiotic Phenotype Through the Molecular Modeling of the Interaction Between LykX-Sym10 Receptor Heterodimer and Nod Factors by Solovev, Yaroslav V., Igolkina, Anna A., Kuliaev, Pavel O., Sulima, Anton S., Zhukov, Vladimir A., Porozov, Yuri B., Pidko, Evgeny A., Andronov, Evgeny E.

“…The difference in symbiotic specificity between peas of Afghanistan and European phenotypes was investigated using molecular modeling. Considering segregating…”
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A Pipeline for Classifying Deleterious Coding Mutations in Agricultural Plants by Kovalev, Maxim S, Igolkina, Anna A, Samsonova, Maria G, Nuzhdin, Sergey V

“…The impact of deleterious variation on both plant fitness and crop productivity is not completely understood and is a hot topic of debates. The deleterious…”
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Matching population diversity of rhizobial nodA and legume NFR5 genes in plant–microbe symbiosis by Igolkina, Anna A., Bazykin, Georgii A., Chizhevskaya, Elena P., Provorov, Nikolai A., Andronov, Evgeny E.

“…We hypothesized that population diversities of partners in nitrogen‐fixing rhizobium–legume symbiosis can be matched for “interplaying” genes. We tested this…”
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Analysis of Gene Expression Variance in Schizophrenia Using Structural Equation Modeling by Igolkina, Anna A, Armoskus, Chris, Newman, Jeremy R B, Evgrafov, Oleg V, McIntyre, Lauren M, Nuzhdin, Sergey V, Samsonova, Maria G

“…Schizophrenia (SCZ) is a psychiatric disorder of unknown etiology. There is evidence suggesting that aberrations in neurodevelopment are a significant…”
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Historical Routes for Diversification of Domesticated Chickpea Inferred from Landrace Genomics by Igolkina, Anna A, Noujdina, Nina V, Vishnyakova, Margarita, Longcore, Travis, von Wettberg, Eric, Nuzhdin, Sergey V, Samsonova, Maria G

“…According to archaeological records, chickpea (Cicer arietinum) was first domesticated in the Fertile Crescent about 10,000 years BP. Its subsequent…”
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Matching population diversity of rhizobial nod A and legume NFR5 genes in plant–microbe symbiosis by Igolkina, Anna A., Bazykin, Georgii A., Chizhevskaya, Elena P., Provorov, Nikolai A., Andronov, Evgeny E.

“…Abstract We hypothesized that population diversities of partners in nitrogen‐fixing rhizobium–legume symbiosis can be matched for “interplaying” genes. We…”
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semopy: A Python Package for Structural Equation Modeling by Igolkina, Anna A., Meshcheryakov, Georgy

“…Structural equation modeling (SEM) is a multivariate statistical technique for estimating complex relationships between observed and latent variables. Although…”
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Abstract IA23: Impact of metastatic prostate cancer on human bone marrow by Baryawno, Ninib, Kfoury, Youmna, Severe, Nicolas, Mei, Shenglin, Gustafsson, Karin, Hirz, Taghreed, Brouse, Thomas, Scadden, Elizabeth W., Igolkina, Anna A., Choi, Bryan D., Barkas, Nikolas, Shin, John H., Saylor, Philip J., Scadden, David T., Sykes, David B., Kharchenko, Peter V.

“…Abstract Cancer-related mortality due to solid tumor malignancies is overwhelmingly due to the development and progression of metastases. In advanced prostate…”
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semopy 2: A Structural Equation Modeling Package with Random Effects in Python by Meshcheryakov, Georgy, Igolkina, Anna A, Samsonova, Maria G

“…Structural Equation Modeling (SEM) is an umbrella term that includes numerous multivariate statistical techniques that are employed throughout a plethora of…”
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