Search Results - "Ignatov, Tanja"

Role of GPR30 in the mechanisms of tamoxifen resistance in breast cancer MCF-7 cells by Ignatov, Atanas, Ignatov, Tanja, Roessner, Albert, Costa, Serban Dan, Kalinski, Thomas

“…Tamoxifen is the most frequently used anti-hormonal drug for treatment of women with hormone-dependent breast cancer. The aim of this study is to investigate…”
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GPER-1 expression is associated with a decreased response rate to primary tamoxifen therapy of breast cancer patients by Ignatov, Tanja, Treeck, Oliver, Kalinski, Thomas, Ortmann, Olaf, Ignatov, Atanas

“…Purpose Endocrine therapies using tamoxifen and/or aromatase inhibitors are important therapeutic options for the targeted treatment of hormone-responsive…”
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G protein-coupled estrogen receptor 1 (GPER-1) and agonist G-1 inhibit growth of ovarian cancer cells by activation of anti-tumoral transcriptome responses: impact of GPER-1 mRNA on survival by Schüler-Toprak, Susanne, Skrzypczak, Maciej, Ignatov, Tanja, Ignatov, Atanas, Ortmann, Olaf, Treeck, Oliver

“…Purpose The present study intended to further elucidate the role of G protein-coupled estrogen receptor 1 (GPER-1) in ovarian cancer by comparing the effects…”
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Comparison of survival of patients with endometrial cancer undergoing sentinel node biopsy alone or systematic lymphadenectomy by Ignatov, Atanas, Papathemelis, Thomas, Ivros, Stylianos, Ignatov, Tanja, Ortmann, Olaf, Eggemann, Holm

“…Background Recently, sentinel lymph node mapping was introduced in the surgical staging of endometrial cancer as alternative to systematic lymphadenectomy…”
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GPER functions as a tumor suppressor in MCF-7 and SK-BR-3 breast cancer cells by Weißenborn, Christine, Ignatov, Tanja, Poehlmann, Angela, Wege, Anja K., Costa, Serban D., Zenclussen, Ana Claudia, Ignatov, Atanas

“…Purpose The orphan, membrane-bound estrogen receptor (GPER) is expressed at high levels in a large fraction of breast cancer patients, and its expression is…”
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APC promoter hypermethylation is an early event in endometrial tumorigenesis by Ignatov, Atanas, Bischoff, Joachim, Ignatov, Tanja, Schwarzenau, Christa, Krebs, Thomas, Kuester, Doerthe, Costa, Serban D., Roessner, Albert, Semczuk, Andrzej, Schneider‐Stock, Regine

“…The aim of the current study was to investigate the role of promoter methylation of adenomatous polyposis coli (APC) and epithelial cadherin (E‐cadherin) genes…”
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GPER-1 acts as a tumor suppressor in ovarian cancer by Ignatov, Tanja, Modl, Saskia, Thulig, Maike, Weißenborn, Christine, Treeck, Oliver, Ortmann, Olaf, Zenclussen, Ac, Costa, Serban Dan, Kalinski, Thomas, Ignatov, Atanas

“…It is known that the new membrane-bound estrogen receptor GPER-1 acts suppressive in breast cancer cells and its expression decreases during disease…”
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GPER-1 Expression Decreases During Breast Cancer Tumorigenesis by Ignatov, Tanja, Weißenborn, Christine, Poehlmann, Angela, Lemke, Antje, Semczuk, Andrzej, Roessner, Albert, Costa, Serban Dan, Kalinski, Thomas, Ignatov, Atanas

“…GPER-1 protein expression was immunohistochemically examined in 164 primary breast cancer specimens and their matched normal breast epithelium. GPER-1…”
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Role of GPR30 in endometrial pathology after tamoxifen for breast cancer by Ignatov, Tanja, MD, Eggemann, Holm, MD, Semczuk, Andrzej, MD, Smith, Bobbie, Bischoff, Joachim, MD, Roessner, Albert, MD, Costa, Serban D., MD, PhD, Kalinski, Thomas, MD, PhD, Ignatov, Atanas, MD

“…Objective This study was undertaken to evaluate the potential role of G-protein-coupled estrogen receptor in endometrial pathology associated with tamoxifen…”
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Patterns of breast cancer relapse in accordance to biological subtype by Ignatov, Atanas, Eggemann, Holm, Burger, Elke, Ignatov, Tanja

“…Purpose To evaluate the pattern of recurrence of breast cancer according to its biological subtype in a large cohort of patients treated with therapy…”
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Loss of HER2 after HER2-targeted treatment by Ignatov, Tanja, Gorbunow, Franceska, Eggemann, Holm, Ortmann, Olaf, Ignatov, Atanas

“…Purpose HER2 expression has been reported to be discordant between primary tumor and metastatic tissue. Patients and methods HER2 discordance and relation to…”
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G-protein-coupled estrogen receptor GPER-1 expression in hormone receptor-positive breast cancer is associated with poor benefit of tamoxifen by Ignatov, Tanja, Claus, Maria, Nass, Norbert, Haybaeck, Johannes, Seifert, Bernd, Kalinski, Thomas, Ortmann, Olaf, Ignatov, Atanas

“…Background The role of G-protein-coupled estrogen receptor 1 (GPER-1) in the development of tamoxifen resistance in breast cancer is a highly controversial…”
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Moderate HER2 expression as a prognostic factor in hormone receptor positive breast cancer by Eggemann, Holm, Ignatov, Tanja, Burger, Elke, Kantelhardt, Eva Johanna, Fettke, Franziska, Thomssen, Christoph, Costa, Serban Dan, Ignatov, Atanas

“…Overexpression and/or amplification of human epidermal growth factor receptor 2 (HER2) is associated with poor prognosis in breast cancer and predicts response…”
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Management of elderly women with endometrial cancer by Eggemann, Holm, Ignatov, Tanja, Burger, Elke, Costa, Serban Dan, Ignatov, Atanas

“…•We analyzed data from population-based tumor registry to determine how elderly patients with endometrial cancer are treated.•Elderly patients with endometrial…”
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Survival advantage of lymphadenectomy in endometrial cancer by Eggemann, Holm, Ignatov, Tanja, Kaiser, Katharina, Burger, Elke, Costa, Serban Dan, Ignatov, Atanas

“…Background The lymphadenectomy in the treatment of endometrial cancer is a topic of ongoing debate. The direct comparison between no lymphadenectomy, pelvic…”
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Accuracy of ultrasound-guided breast-conserving surgery in the determination of adequate surgical margins by Eggemann, Holm, Ignatov, Tanja, Costa, Serban Dan, Ignatov, Atanas

“…The goal of this study was to assess the size of the ultrasound-measured margin associated with an adequate surgical margin during breast-conserving surgery…”
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Oncologic Outcome of Robotic-Assisted and Laparoscopic Sentinel Node Biopsy in Endometrial Cancer by Ignatov, Atanas, Mészáros, József, Ivros, Stylianos, Gennari, Paolo, Ignatov, Tanja

“…Recently, sentinel lymph node biopsy (SLNB) has been introduced in the surgical staging of endometrial cancer as an alternative to systematic lymph node…”
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Management of small T1a/b breast cancer by tumor subtype by Ignatov, Tanja, Eggemann, Holm, Burger, Elke, Costa, Serban Dan, Ignatov, Atanas

“…Background The treatment of patients with small (T1a/b) breast cancer is based on retrospective analysis. The influence of intrinsic tumor subtypes on…”
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Management of elderly women with cervical cancer by Eggemann, Holm, Ignatov, Tanja, Geyken, Christina Henrike, Seitz, Stephan, Ignatov, Atanas

“…Background Elderly women with cervical cancer receive less therapy in comparison with their younger counterparts. The exact reason(s) for this treatment…”
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Endometrial cancer subtypes are associated with different patterns of recurrence by Ignatov, Tanja, Eggemann, Holm, Costa, Serban Dan, Ortmann, Olaf, Ignatov, Atanas

“…Purpose To evaluate the pattern of endometrial cancer recurrence according to its biological subtype in a large cohort of patients. Patients and methods…”
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