Search Results - "Ignarro, Louis J"

Biological hydropersulfides and related polysulfides – a new concept and perspective in redox biology by Fukuto, Jon M., Ignarro, Louis J., Nagy, Peter, Wink, David A., Kevil, Christopher G., Feelisch, Martin, Cortese‐Krott, Miriam M., Bianco, Christopher L., Kumagai, Yoshito, Hobbs, Adrian J., Lin, Joseph, Ida, Tomoaki, Akaike, Takaaki

“…The chemical biology of thiols (RSH, e.g., cysteine and cysteine‐containing proteins/peptides) has been a topic of extreme interest for many decades due to…”
Get full text

Nitric oxide and pathogenic mechanisms involved in the development of vascular diseases by Napoli, Claudio, Ignarro, Louis J.

“…Nitric oxide (NO) is a pivotal signaling messenger in the cardiovascular system. NO participates in regulatory functions including control of hemostasis,…”
Get full text

Clonogenic Multipotent Stem Cells in Human Adipose Tissue Differentiate into Functional Smooth Muscle Cells by Rodríguez, Larissa V., Alfonso, Zeni, Zhang, Rong, Leung, Joanne, Wu, Benjamin, Ignarro, Louis J.

“…Smooth muscle is a major component of human tissues and is essential for the normal function of a multitude of organs including the intestine, urinary tract…”
Get full text

Hydrogen sulfide as a mediator of human corpus cavernosum smooth-muscle relaxation by d'Emmanuele di Villa Bianca, Roberta, Sorrentino, Raffaella, Maffia, Pasquale, Mirone, Vincenzo, Imbimbo, Ciro, Fusco, Ferdinando, De Palma, Raffaele, Ignarro, Louis J, Cirino, Giuseppe

“…Hydrogen sulfide (H₂S) is synthesized by 2 enzymes, cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE). L-Cysteine (L-Cys) acts as a natural…”
Get full text

Free radical biology and medicine: it's a gas, man by Pryor, William A, Houk, Kendall N, Foote, Christopher S, Fukuto, Jon M, Ignarro, Louis J, Squadrito, Giuseppe L, Davies, Kelvin J A

“…We review gases that can affect oxidative stress and that themselves may be radicals. We discuss O(2) toxicity, invoking superoxide, hydrogen peroxide, and the…”
Get more information

Endothelial cellular senescence is inhibited by liver X receptor activation with an additional mechanism for its atheroprotection in diabetes by Hayashi, Toshio, Kotani, Hitoshi, Yamaguchi, Tomoe, Taguchi, Kumiko, Iida, Mayu, Ina, Koichiro, Maeda, Morihiko, Kuzuya, Masafumi, Hattori, Yuichi, Ignarro, Louis J.

“…Senescence of vascular endothelial cells leads to endothelial dysfunction and contributes to the progression of atherosclerosis. Liver X receptors (LXRs) are…”
Get full text

Inhaled NO and COVID‐19 by Ignarro, Louis J.

Get full text

Nitric Oxide: Biology and Pathobiology by Ignarro, Louis J

“…Nitric oxide (NO) is a gas naturally found in the body that conveys information between cells. In the last decade researchers have found that NO is a signaling…”
Get full text

Exacerbated Neuropathy in POLAR A and M Trials Due to Redox Interaction of PledOx-Associated Mn2+ and Oxaliplatin-Associated Pt2 by Karlsson, Jan Olof G., Jynge, Per, Ignarro, Louis J.

“…Disappointing results from the POLAR A and M phase III trials involving colorectal cancer patients on chemotherapy with FOLFOX6 in curative (A) and palliative…”
Get full text

Nitric oxide-releasing drugs by NAPOLI, Claudio, IGNARRO, Louis J

“…Pharmacological compounds that release nitric oxide (NO) have been useful tools for evaluating the broad role of NO in physiology and therapeutics. NO…”
Get full text

Endothelial Cellular Senescence Is Inhibited by Nitric Oxide: Implications in Atherosclerosis Associated with Menopause and Diabetes by Hayashi, Toshio, Matsui-Hirai, Hisako, Miyazaki-Akita, Asaka, Fukatsu, Akiko, Funami, Jun, Ding, Qun-Fang, Kamalanathan, Sumitra, Hattori, Yuichi, Ignarro, Louis J., Iguchi, Akihisa

“…Senescence may contribute to the pathogenesis of atherosclerosis. Although the bioavailability of nitric oxide (NO) is limited in senescence, the effect of NO…”
Get full text

The Link Between Erectile and Cardiovascular Health: The Canary in the Coal Mine by Meldrum, David R., MD, Gambone, Joseph C., DO, MPH, Morris, Marge A., MEd, RD, CDE, Meldrum, Donald A.N., MD, Esposito, Katherine, MD, PhD, Ignarro, Louis J., PhD

“…Lifestyle and nutrition have been increasingly recognized as central factors influencing vascular nitric oxide (NO) production and erectile function. This…”
Get full text

Erectile Hydraulics: Maximizing Inflow While Minimizing Outflow by Meldrum, David R., Burnett, Arthur L., Dorey, Grace, Esposito, Katherine, Ignarro, Louis J.

“…Penile rigidity depends on maximizing inflow while minimizing outflow. The aim of this review is to describe the principal factors and mechanisms involved…”
Get full text

Nitric oxide is not just blowing in the wind by Ignarro, Louis J

“…Linked Articles This article is part of a themed section on Nitric Oxide 20 Years from the 1998 Nobel Prize. To view the other articles in this section visit…”
Get full text

The Damaging Outcome of the POLAR Phase III Trials Was Due to Avoidable Time-Dependent Redox Interaction between Oxaliplatin and PledOx by Karlsson, Jan Olof G, Jynge, Per, Ignarro, Louis J

“…On 2 July 2021, highly negative results were reported from the POLAR A and M phase III trials in patients with colorectal cancer, treated with an…”
Get full text

CXCR4/YY1 inhibition impairs VEGF network and angiogenesis during malignancy by de Nigris, Filomena, Crudele, Valeria, Giovane, Alfonso, Casamassimi, Amelia, Giordano, Antonio, Garban, Hermes J., Cacciatore, Francesco, Pentimalli, Francesca, Marquez-Garban, Diana C., Petrillo, Antonella, Cito, Letizia, Sommese, Linda, Fiore, Andrea, Petrillo, Mario, Siani, Alfredo, Barbieri, Antonio, Arra, Claudio, Rengo, Franco, Hayashi, Toshio, Al-Omran, Mohammed, Ignarro, Louis J., Napoli, Claudio

“…Tumor growth requires neoangiogenesis. VEGF is the most potent proangiogenic factor. Dysregulation of hypoxia-inducible factor (HIF) or cytokine stimuli such…”
Get full text

Endothelial progenitor cells as therapeutic agents in the microcirculation: An update by Napoli, Claudio, Hayashi, Toshio, Cacciatore, Francesco, Casamassimi, Amelia, Casini, Costanza, Al-Omran, Mohammed, Ignarro, Louis J

“…Abstract This review evaluates novel beneficial effects of circulating endothelial progenitor cells (EPCs) as shown by several preclinical studies and clinical…”
Get full text

May Mangafodipir or Other SOD Mimetics Contribute to Better Care in COVID-19 Patients? by Karlsson, Jan Olof G, Jynge, Per, Ignarro, Louis J

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is characterized by massive inflammation of the arterial endothelium accompanied by…”
Get full text

The role of oxidative stress in adult critical care by Crimi, Ettore, Sica, Vincenzo, Williams-Ignarro, Sharon, Zhang, Haibo, Slutsky, Arthur S., Ignarro, Louis J., Napoli, Claudio

“…Oxidative stress defines an imbalance in production of oxidizing chemical species and their effective removal by protective antioxidants and scavenger enzymes…”
Get full text

Dose-dependent modulatory effects of insulin on glucose-induced endothelial senescence in vitro and in vivo: a relationship between telomeres and nitric oxide by Matsui-Hirai, Hisako, Hayashi, Toshio, Yamamoto, Seiji, Ina, Koichiro, Maeda, Morihiko, Kotani, Hitoshi, Iguchi, Akihisa, Ignarro, Louis J, Hattori, Yuichi

“…The elderly are prone to postprandial hyperglycemia that increases their cardiovascular risk. Although insulin therapy is necessary to treat diabetes, high…”
Get more information