Search Results - "Iglesias, Pablo"

Molecular mechanisms of cellular mechanosensing by Luo, Tianzhi, Mohan, Krithika, Iglesias, Pablo A., Robinson, Douglas N.

“…Mechanical forces direct a host of cellular and tissue processes. Although much emphasis has been placed on cell-adhesion complexes as force sensors, the…”
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Excitable Signal Transduction Networks in Directed Cell Migration by Devreotes, Peter N, Bhattacharya, Sayak, Edwards, Marc, Iglesias, Pablo A, Lampert, Thomas, Miao, Yuchuan

“…Although directed migration of eukaryotic cells may have evolved to escape nutrient depletion, it has been adopted for an extensive range of physiological…”
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Mechanoaccumulative Elements of the Mammalian Actin Cytoskeleton by Schiffhauer, Eric S., Luo, Tianzhi, Mohan, Krithika, Srivastava, Vasudha, Qian, Xuyu, Griffis, Eric R., Iglesias, Pablo A., Robinson, Douglas N.

“…To change shape, divide, form junctions, and migrate, cells reorganize their cytoskeletons in response to changing mechanical environments [1–4]. Actin…”
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Enhanced chemotaxis through spatially regulated absolute concentration robustness by Biswas, Debojyoti, Bhattacharya, Sayak, Iglesias, Pablo A.

“…Chemotaxis, the directional motility of cells in response to spatial gradients of chemical cues, is a fundamental process behind a wide range of biological…”
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Interaction of motility, directional sensing, and polarity modules recreates the behaviors of chemotaxing cells by Shi, Changji, Huang, Chuan-Hsiang, Devreotes, Peter N, Iglesias, Pablo A

“…Chemotaxis involves the coordinated action of separable but interrelated processes: motility, gradient sensing, and polarization. We have hypothesized that…”
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Altering the threshold of an excitable signal transduction network changes cell migratory modes by Miao, Yuchuan, Bhattacharya, Sayak, Edwards, Marc, Cai, Huaqing, Inoue, Takanari, Iglesias, Pablo A., Devreotes, Peter N.

“…The diverse migratory modes displayed by different cell types are generally believed to be idiosyncratic. Here we show that the migratory behaviour of…”
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An Excitable Ras/PI3K/ERK Signaling Network Controls Migration and Oncogenic Transformation in Epithelial Cells by Zhan, Huiwang, Bhattacharya, Sayak, Cai, Huaqing, Iglesias, Pablo A., Huang, Chuan-Hsiang, Devreotes, Peter N.

“…The Ras/PI3K/extracellular signal-regulated kinases (ERK) signaling network plays fundamental roles in cell growth, survival, and migration and is frequently…”
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Three-dimensional stochastic simulation of chemoattractant-mediated excitability in cells by Biswas, Debojyoti, Devreotes, Peter N, Iglesias, Pablo A

“…During the last decade, a consensus has emerged that the stochastic triggering of an excitable system drives pseudopod formation and subsequent migration of…”
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Spatiotemporal dynamics of membrane surface charge regulates cell polarity and migration by Banerjee, Tatsat, Biswas, Debojyoti, Pal, Dhiman Sankar, Miao, Yuchuan, Iglesias, Pablo A., Devreotes, Peter N.

“…During cell migration and polarization, numerous signal transduction and cytoskeletal components self-organize to generate localized protrusions. Although…”
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Biased excitable networks: how cells direct motion in response to gradients by Iglesias, Pablo A, Devreotes, Peter N

“…Highlights ► The actin cytoskeleton in motile cells behaves as an excitable medium. ► This excitable behavior can account for the spontaneous migration of…”
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Deciphering cell signaling networks with massively multiplexed biosensor barcoding by Yang, Jr-Ming, Chi, Wei-Yu, Liang, Jessica, Takayanagi, Saki, Iglesias, Pablo A., Huang, Chuan-Hsiang

“…Genetically encoded fluorescent biosensors are powerful tools for monitoring biochemical activities in live cells, but their multiplexing capacity is limited…”
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An excitable signal integrator couples to an idling cytoskeletal oscillator to drive cell migration by Huang, Chuan-Hsiang, Tang, Ming, Shi, Changji, Iglesias, Pablo A., Devreotes, Peter N.

“…It is generally believed that cytoskeletal activities drive random cell migration, whereas signal transduction events initiated by receptors regulate the…”
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Understanding the Cooperative Interaction between Myosin II and Actin Cross-Linkers Mediated by Actin Filaments during Mechanosensation by Luo, Tianzhi, Mohan, Krithika, Srivastava, Vasudha, Ren, Yixin, Iglesias, Pablo A., Robinson, Douglas N.

“…Myosin II is a central mechanoenzyme in a wide range of cellular morphogenic processes. Its cellular localization is dependent not only on signal transduction…”
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The threshold of an excitable system serves as a control mechanism for noise filtering during chemotaxis by Bhattacharya, Sayak, Iglesias, Pablo A

“…Chemotaxis, the migration of cells in the direction of a chemical gradient, is of utmost importance in various biological processes. In recent years, research…”
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Balancing at the edge of excitability: implications for cell movement by Biswas, Debojyoti, Banerjee, Parijat, Iglesias, Pablo A.

“…Cells rely on the ability to sense and respond to small spatial differences in chemoattractant concentrations for survival. There is growing evidence that this…”
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Sensitivity minimization, biological homeostasis and information theory by Biswas, Debojyoti, Iglesias, Pablo A.

“…All organisms must be able to adapt to changes in the environment. To this end, they have developed sophisticated regulatory mechanisms to ensure homeostasis…”
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Cells navigate with a local-excitation, global-inhibition-biased excitable network by Xiong, Yuan, Huang, Chuan-Hsiang, Iglesias, Pablo A., Devreotes, Peter N.

“…Cells have an internal compass that enables them to move along shallow chemical gradients. As amoeboid cells migrate, signaling events such as Ras and PI3K…”
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Controlling excitable wave behaviors through the tuning of three parameters by Bhattacharya, Sayak, Iglesias, Pablo A.

“…Excitable systems are a class of dynamical systems that can generate self-sustaining waves of activity. These waves are known to manifest differently under…”
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Dynamic properties of network motifs contribute to biological network organization by Prill, Robert J, Iglesias, Pablo A, Levchenko, Andre

“…Biological networks, such as those describing gene regulation, signal transduction, and neural synapses, are representations of large-scale dynamic systems…”
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Navigating through models of chemotaxis by Iglesias, Pablo A, Devreotes, Peter N

“…Chemotaxis in eukaryotic cells involves the coordination of several related but separable processes: motility, polarization, and gradient sensing. Mathematical…”
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