Search Results - "Igel, Patrick"

Synthesis and Structure−Activity Relationships of Cyanoguanidine-Type and Structurally Related Histamine H4 Receptor Agonists by Igel, Patrick, Geyer, Roland, Strasser, Andrea, Dove, Stefan, Seifert, Roland, Buschauer, Armin

“…Recently, we identified high-affinity human histamine H3 (hH3R) and H4 receptor (hH4R) ligands among a series of NG-acylated imidazolylpropylguanidines, which…”
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Expression and functional properties of canine, rat, and murine histamine H4 receptors in Sf9 insect cells by Schnell, David, Brunskole, Irena, Ladova, Katerina, Schneider, Erich H., Igel, Patrick, Dove, Stefan, Buschauer, Armin, Seifert, Roland

“…The histamine H 4 receptor (H 4 R) is expressed on cells of the immune system including eosinophils, dendritic cells, and T cells and plays an important role…”
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Tritium-Labeled N1-[3-(1H-imidazol-4-yl)propyl]-N2-propionylguanidine ([3H]UR-PI294), a High-Affinity Histamine H3 and H4 Receptor Radioligand by Igel, Patrick, Schnell, David, Bernhardt, Günther, Seifert, Roland, Buschauer, Armin

“…Histamine mediates its various functions through four histamine receptor subtypes. The H3 subtype is mainly found in the central nervous system, where it…”
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Discovery of a Tritiated Radioligand with High Affinity and Selectivity for the Histamine H 3 Receptor by Mönnich, Denise, Nagl, Martin, Forster, Lisa, Rosier, Niklas, Igel, Patrick, Pockes, Steffen

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Discovery of a Tritiated Radioligand with High Affinity and Selectivity for the Histamine H3 Receptor by Mönnich, Denise, Nagl, Martin, ster, Lisa, Rosier, Niklas, Igel, Patrick, Pockes, Steffen

“…Radioligands used previously for histamine H3 receptor (H3R) are accompanied by a number of disadvantages. In this study, we report the synthesis of the new…”
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Histamine H 4 receptor agonists by Igel, Patrick, Dove, Stefan, Buschauer, Armin

“…Since its discovery 10 years ago the histamine H 4 receptor (H 4R) has attracted attention as a potential drug target, for instance, for the treatment of…”
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Histamine H4 receptor agonists by IGEL, Patrick, DOVE, Stefan, BUSCHAUER, Armin

“…Since its discovery 10 years ago the histamine H(4) receptor (H(4)R) has attracted attention as a potential drug target, for instance, for the treatment of…”
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Synthesis and Structure−Activity Relationships of Cyanoguanidine-Type and Structurally Related Histamine H 4 Receptor Agonists by Igel, Patrick, Geyer, Roland, Strasser, Andrea, Dove, Stefan, Seifert, Roland, Buschauer, Armin

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N(G)-acylated imidazolylpropylguanidines as potent histamine H4 receptor agonists: selectivity by variation of the N(G)-substituent by Igel, Patrick, Schneider, Erich, Schnell, David, Elz, Sigurd, Seifert, Roland, Buschauer, Armin

“…3-(1H-Imidazol-4-yl)propylguanidine (SK&F 91486, 4) was identified as a potent partial agonist at the human histamine H(3) receptor (hH(3)R) and human…”
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N G -Acylated Imidazolylpropylguanidines as Potent Histamine H 4 Receptor Agonists: Selectivity by Variation of the N G -Substituent by Igel, Patrick, Schneider, Erich, Schnell, David, Elz, Sigurd, Seifert, Roland, Buschauer, Armin

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Conformations, Conformational Preferences, and Conformational Exchange of N′-Substituted N-Acylguanidines: Intermolecular Interactions Hold the Key by Kleinmaier, Roland, Keller, Max, Igel, Patrick, Buschauer, Armin, Gschwind, Ruth M

“…Guanidine and acylguanidine groups are crucial structural features of numerous biologically active compounds. Depending on the biological target,…”
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Acylguanidines as Bioisosteres of Guanidines: N G -Acylated Imidazolylpropylguanidines, a New Class of Histamine H 2 Receptor Agonists by Ghorai, Prasanta, Kraus, Anja, Keller, Max, Götte, Carsten, Igel, Patrick, Schneider, Erich, Schnell, David, Bernhardt, Günther, Dove, Stefan, Zabel, Manfred, Elz, Sigurd, Seifert, Roland, Buschauer, Armin

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Tritium‐Labeled N 1 ‐[3‐(1 H ‐imidazol‐4‐yl)propyl]‐ N 2 ‐propionylguanidine ([ 3 H]UR‐PI294), a High‐Affinity Histamine H 3 and H 4 Receptor Radioligand by Igel, Patrick, Schnell, David, Bernhardt, Günther, Seifert, Roland, Buschauer, Armin

“…Abstract Histamine mediates its various functions through four histamine receptor subtypes. The H 3 subtype is mainly found in the central nervous system,…”
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Functional reconstitution of human neuropeptide Y (NPY) Y 2 and Y 4 receptors in Sf9 insect cells by Pop, Nathalie, Igel, Patrick, Brennauer, Albert, Cabrele, Chiara, Bernhardt, Günther, Seifert, Roland, Buschauer, Armin

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NG-Acylated Imidazolylpropylguanidines as Potent Histamine H4 Receptor Agonists : Selectivity by Variation of the NG-Substituent by IGEL, Patrick, SCHNEIDER, Erich, SCHNELL, David, ELZ, Sigurd, SEIFERT, Roland, BUSCHAUER, Armin

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Functional reconstitution of human neuropeptide Y (NPY) Y2 and Y4 receptors in Sf9 insect cells by Pop, Nathalie, Igel, Patrick, Brennauer, Albert, Cabrele, Chiara, Bernhardt, Günther, Seifert, Roland, Buschauer, Armin

“…The four functionally expressed human neuropeptide Y receptor subtypes (hY1R, hY2R, hY4R, hY5R) belong to class A of the G-protein-coupled receptors (GPCRs)…”
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Acylguanidines as Bioisosteres of Guanidines: NG-Acylated Imidazolylpropylguanidines, a New Class of Histamine H2 Receptor Agonists by GHORAI, Prasanta, KRAUS, Anja, KELLER, Max, GÖTTE, Carsten, IGEL, Patrick, SCHNEIDER, Erich, SCHNELL, David, BERNHARDT, Günther, DOVE, Stefan, ZABEL, Manfred, ELZ, Sigurd, SEIFERT, Roland, BUSCHAUER, Armin

“…N1-Aryl(heteroaryl)alkyl-N2-[3-(1H-imidazol-4-yl)propyl]guanidines are potent histamine H2-receptor (H2R) agonists, but their applicability is compromised by…”
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Inside Cover: Tritium‐Labeled N 1 ‐[3‐(1 H ‐imidazol‐4‐yl)propyl]‐ N 2 ‐propionylguanidine ([ 3 H]UR‐PI294), a High‐Affinity Histamine H 3 and H 4 Receptor Radioligand / N G ‐Acylated Aminothiazolylpropylguanidines as Potent and Selective Histamine H 2 Receptor Agonists (ChemMedChem 2/2009) by Igel, Patrick, Schnell, David, Bernhardt, Günther, Seifert, Roland, Buschauer, Armin, Kraus, Anja, Ghorai, Prasanta, Birnkammer, Tobias, Elz, Sigurd, Dove, Stefan

“…Abstract The inside cover picture shows the human histamine H 2 receptor and the H 2 and H 3 /H 4 receptor‐selective ligands identified. Bioisosteric…”
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Inside Cover: Tritium-Labeled N1-[3-(1H-imidazol-4-yl)propyl]-N2-propionylguanidine ([3H]UR-PI294), a High-Affinity Histamine H3 and H4 Receptor Radioligand / NG-Acylated Aminothiazolylpropylguanidines as Potent and Selective Histamine H2 Receptor Agonists (ChemMedChem 2/2009) by Igel, Patrick, Schnell, David, Bernhardt, Günther, Seifert, Roland, Buschauer, Armin, Kraus, Anja, Ghorai, Prasanta, Birnkammer, Tobias, Elz, Sigurd, Dove, Stefan

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Functional reconstitution of human neuropeptide Y (NPY) Y(2) and Y(4) receptors in Sf9 insect cells by Pop, Nathalie, Igel, Patrick, Brennauer, Albert, Cabrele, Chiara, Bernhardt, G Nther, Seifert, Roland, Buschauer, Armin

“…The four functionally expressed human neuropeptide Y receptor subtypes (hY(1)R, hY(2)R, hY(4)R, hY(5)R) belong to class A of the G-protein-coupled receptors…”
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