Search Results - "Igbavboa, U."

Amyloid β-protein stimulates trafficking of cholesterol and caveolin-1 from the plasma membrane to the Golgi complex in mouse primary astrocytes by Igbavboa, U, Sun, G.Y, Weisman, G.A, He, Yan, Wood, W.G

“…Abstract The Golgi complex plays a key role in cholesterol trafficking in cells. Our earlier study demonstrated amyloid β-protein (Aβ) alters cholesterol…”
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Amyloid beta-peptide1-40 increases neuronal membrane fluidity: role of cholesterol and brain region by Chochina, S V, Avdulov, N A, Igbavboa, U, Cleary, J P, O'Hare, E O, Wood, W G

“…There is increasing evidence of an interaction between cholesterol dynamics and Alzheimer's disease (AD), and amyloid beta-peptide may play an important role…”
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Murine synaptosomal lipid raft protein and lipid composition are altered by expression of human apoE 3 and 4 and by increasing age by Igbavboa, U., Eckert, G.P., Malo, T.M., Studniski, A.E., Johnson, L.N.A., Yamamoto, N., Kobayashi, M., Fujita, S.C., Appel, T.R., Müller, W.E., Wood, W.G., Yanagisawa, K.

“…Apolipoprotein E (apoE) 4 and aging are risk factors for Alzheimer's disease (AD). Mice expressing human apoE4 and aged wild-type mice show a similarity in the…”
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Simvastatin protects neurons from cytotoxicity by up-regulating Bcl-2 mRNA and protein in vivo and in vitro by Johnson-Anuna, L.N, Eckert, G.P, Igbavboa, U, Muller, W.E, Wood, W.G

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Cholesterol trafficking and amyloid beta peptides by Wood, W G, Igbavboa, U

“…Currently, there is much interest in the association between cholesterol and Alzheimer's disease. An especially important aspect of this association is the…”
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Cholesterol Efflux to High-Density Lipoproteins and Apolipoprotein A-I Phosphatidylcholine Complexes Is Inhibited by Ethanol:  Role of Apolipoprotein Structure and Cooperative Interaction of Phosphatidylcholine and Cholesterol by Avdulov, Nicolai A, Chochina, Svetlana V, Igbavboa, Urule, Wood, W. Gibson

“…There is a substantial body of evidence showing that moderate alcohol consumption is associated with a reduced risk of cardiovascular morbidity and mortality…”
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Age differences in the expression of metabotropic glutamate receptor 1 and inositol 1,4,5-trisphosphate receptor in mouse cerebellum by Simonyi, A, Xia, J, Igbavboa, U, Wood, W.G, Sun, G.Y

“…Age differences in the expression of cerebellar metabotropic glutamate receptor 1 (mGluR1) and inositol 1,4,5-trisphosphate receptor (IP 3R) were investigated…”
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Chronic administration of statins alters multiple gene expression patterns in mouse cerebral cortex by Johnson-Anuna, Leslie N, Eckert, Gunter P, Keller, Jan H, Igbavboa, Urule, Franke, Cornelia, Fechner, Thomas, Schubert-Zsilavecz, Manfred, Karas, Michael, Müller, Walter E, Wood, W Gibson

“…Statins have been reported to lower the risk of developing Alzheimer's disease; however, the mechanism of this potentially important neuroprotective action is…”
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Amyloid beta-protein interactions with membranes and cholesterol: causes or casualties of Alzheimer's disease by Gibson Wood, W., Eckert, Gunter P., Igbavboa, Urule, Müller, Walter E.

“…Amyloid beta-protein (Aβ) is thought to be one of the primary factors causing neurodegeneration in Alzheimer's disease (AD). This protein is an amphipathic…”
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Regulation of reverse uniport activity in mitochondria by extramitochondrial divalent cations. Dependence on a soluble intermembrane space component by IGBAVBOA, U, PFEIFFER, D. R

“…We previously reported that uncoupling Ca2(+)-loaded mitochondria in the presence of [ethylenebis(oxyethylenenitrilo)]tetraacetic acid (EGTA) produces a…”
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Brain membrane cholesterol domains, aging and amyloid beta-peptides by Wood, W.Gibson, Schroeder, Friedhelm, Igbavboa, Urule, Avdulov, Nicolai A, Chochina, Svetlana V

“…Lipids are essential for the structural and functional integrity of membranes. Membrane lipids are not randomly distributed but are localized in different…”
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Amyloid beta-protein1-42 increases cAMP and apolipoprotein E levels which are inhibited by β1 and β2-adrenergic receptor antagonists in mouse primary astrocytes by Igbavboa, U., Johnson-Anuna, L.N., Rossello, X., Butterick, T.A., Sun, G.Y., Wood, W.G.

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EGTA inhibits reverse uniport-dependent Ca2+ release from uncoupled mitochondria. Possible regulation of the Ca2+ uniporter by a Ca2+ binding site on the cytoplasmic side of the inner membrane by Igbavboa, U, Pfeiffer, D R

“…When rat liver mitochondria are allowed to accumulate Ca2+, treated with ruthenium red to inhibit reverse activity of the Ca2+ uniporter, and then treated with…”
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Lipid rafts of purified mouse brain synaptosomes prepared with or without detergent reveal different lipid and protein domains by Eckert, Gunter P, Igbavboa, Urule, Müller, Walter E, Wood, W.Gibson

“…Lipid rafts have been proposed to be important in a variety of functions including lipid transport, signal transduction and cell growth. There is increasing…”
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Cholesterol is increased in the exofacial leaflet of synaptic plasma membranes of human apolipoprotein E4 knock-in mice by Hayashi, Hideki, Igbavboa, Urule, Hamanaka, Hiroki, Kobayashi, Mariko, Fujita, Shinobu C, Gibson Wood, W, Yanagisawa, Katsuhiko

“…Inheritance of the apolipoprotein (apoE) 4 allele is a risk factor for developing Alzheimerʼs disease (AD). The purpose of the present study was to determine…”
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Distribution and fluidizing action of soluble and aggregated amyloid beta-peptide in rat synaptic plasma membranes by Mason, R P, Jacob, R F, Walter, M F, Mason, P E, Avdulov, N A, Chochina, S V, Igbavboa, U, Wood, W G

“…The effects of soluble and aggregated amyloid beta-peptide (Abeta) on cortical synaptic plasma membrane (SPM) structure were examined using small angle x-ray…”
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Alternative formation of anthraquinones and lipoquinones in heterotrophic and photoautotrophic cell suspension cultures of Morinda lucida Benth by Igbavboa, U, Sieweke, H.J, Leistner, E, Rower, I, Husemann, W, Barz, W

“…Photoheterotrophic and photoautotrophic cell suspension cultures were raised from a callus tissue derived from a Morinda lucida Benth. plant (Rubiaceae). The…”
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Lipid Binding to Amyloid β‐Peptide Aggregates: Preferential Binding of Cholesterol as Compared with Phosphatidylcholine and Fatty Acids by Avdulov, Nicolai A., Chochina, Svetlana V., Igbavboa, Urule, Warden, Christopher S., Vassiliev, Alexei V., Wood, W. Gibson

“…: Amyloid β‐peptide (Aβ) aggregates are one of the key neuropathological characteristics of Alzheimer's disease. Aβ belongs to a group of proteins that…”
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Amyloid beta-protein 1-42 increases cAMP and apolipoprotein E levels which are inhibited by β 1 and β 2-adrenergic receptor antagonists in mouse primary astrocytes by Igbavboa, U., Johnson-Anuna, L.N., Rossello, X., Butterick, T.A., Sun, G.Y., Wood, W.G.

“…Amyloid beta-protein (Aβ) increases apolipoprotein E (apoE) levels in astrocytes which could alter lipid trafficking. The mechanism for the Aβ-induced increase…”
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A new role for apolipoprotein E: modulating transport of polyunsaturated phospholipid molecular species in synaptic plasma membranes by Igbavboa, Urule, Hamilton, Jillonne, Kim, Hee‐Yong, Sun, Grace Y., Wood, W. Gibson

“…Phospholipids and their acyl group composition are important in providing the proper membrane environment for membrane protein structure and function. In…”
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