Search Results - "Igawa, Kazuyo"

Gelatin-based cell culture device for construction and X-ray irradiation of a three-dimensional oral cancer model by Bessho, Tomoka, Takagi, Tomoko, Igawa, Kazuyo, Sato, Kae

“…Bioassays using three-dimensional (3D) tissue models offer several advantages over 2D culture assays because they can reproduce the structure and function of…”
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Radiation evaluation assay using a human three-dimensional oral cancer model for clinical radiation therapy by Sercombe, Lucie, Igawa, Kazuyo, Izumi, Kenji

“…With the development of various radiation-based cancer therapies, radiobiological evaluation methods instead of traditional clonogenic assays with monolayer…”
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Scaling parameter of the lethal effect of mammalian cells based on radiation-induced OH radicals: effectiveness of direct action in radiation therapy by Kusumoto, Tamon, Ogawara, Ryo, Igawa, Kazuyo, Baba, Kentaro, Konishi, Teruaki, Furusawa, Yoshiya, Kodaira, Satoshi

“…ABSTRACT We have been studying the effectiveness of direct action, which induces clustered DNA damage leading to cell killing, relative to indirect action…”
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Development of the Follow-Up Human 3D Oral Cancer Model in Cancer Treatment by Igawa, Kazuyo, Izumi, Kenji, Sakurai, Yoshinori

“…As function preservation cancer therapy, targeted radiation therapies have been developed for the quality of life of cancer patients. However, preclinical…”
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Development of an osteoblast-based 3D continuous-perfusion microfluidic system for drug screening by Jang, Kihoon, Sato, Kae, Igawa, Kazuyo, Chung, Ung-il, Kitamori, Takehiko

“…In this work, we demonstrated that biological cells could be cultured in a continuous-perfusion glass microchip system for drug screening. We used mouse…”
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Development and Characterization of a Three-Dimensional Organotypic In Vitro Oral Cancer Model with Four Co-Cultured Cell Types, Including Patient-Derived Cancer-Associated Fibroblasts by Aizawa, Yuka, Haga, Kenta, Yoshiba, Nagako, Yortchan, Witsanu, Takada, Sho, Tanaka, Rintaro, Naito, Eriko, Abé, Tatsuya, Maruyama, Satoshi, Yamazaki, Manabu, Tanuma, Jun-Ichi, Igawa, Kazuyo, Tomihara, Kei, Togo, Shinsaku, Izumi, Kenji

“…Cancer organoids have emerged as a valuable tool of three-dimensional (3D) cell cultures to investigate tumor heterogeneity and predict tumor behavior and…”
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Maxillofacial reconstruction using custom-made artificial bones fabricated by inkjet printing technology by Saijo, Hideto, Igawa, Kazuyo, Kanno, Yuki, Mori, Yoshiyuki, Kondo, Kayoko, Shimizu, Koutaro, Suzuki, Shigeki, Chikazu, Daichi, Iino, Mitsuki, Anzai, Masahiro, Sasaki, Nobuo, Chung, Ung-il, Takato, Tsuyoshi

“…Ideally, artificial bones should be dimensionally compatible with deformities, and be biodegradable and osteoconductive; however, there are no artificial bones…”
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Molecular and structural patterns of bone regeneration in surgically created defects containing bone substitutes by Elgali, Ibrahim, Igawa, Kazuyo, Palmquist, Anders, Lennerås, Maria, Xia, Wei, Choi, Sungjin, Chung, Ung-Il, Omar, Omar, Thomsen, Peter

“…Abstract Several biomaterials have been introduced for bone augmentation. However, information is lacking about the mechanisms of bone regeneration and/or…”
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In Vitro Studies to Define the Cell-Surface and Intracellular Targets of Polyarginine-Conjugated Sodium Borocaptate as a Potential Delivery Agent for Boron Neutron Capture Therapy by Fujimura, Atsushi, Yasui, Seiji, Igawa, Kazuyo, Ueda, Ai, Watanabe, Kaori, Hanafusa, Tadashi, Ichikawa, Yasuaki, Yoshihashi, Sachiko, Tsuchida, Kazuki, Kamiya, Atsunori, Furuya, Shuichi

“…Boron neutron capture therapy (BNCT) requires pharmaceutical innovations and molecular-based evidence of effectiveness to become a standard cancer therapeutic…”
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Prevention and early management of carotid blowout syndrome for patients receiving head and neck salvage boron neutron capture therapy (BNCT) by Lan, Tien-Li, Chang, Feng-Chi, Wang, Chun-Wei, Igawa, Kazuyo, Wu, Szu-Hsien, Lo, Wen-Liang, Chen, Yi-Wei

“…The incidence rate of oral and pharyngeal cancers in Taiwan has increased gradually over the past few decades. The standard treatment strategy for oral and…”
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Development and evaluation of tetrapod-shaped granular artificial bones by Choi, Sungjin, Liu, I-li, Yamamoto, Kenichi, Igawa, Kazuyo, Mochizuki, Manabu, Sakai, Takamasa, Echigo, Ryosuke, Honnami, Muneki, Suzuki, Shigeki, Chung, Ung-il, Sasaki, Nobuo

“…We have developed a novel form of granular artificial bone “Tetrabones” with a homogeneous tetrapod shape and uniform size. Tetrabones are four armed…”
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Poster 132: Mini-Tetrapod Bone Filler by Igawa, Kazuyo, DDS

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Changes in Bone Regeneration by Trehalose Coating and Basic Fibroblast Growth Factor after Implantation of Tailor-Made Bone Implants in Dogs by CHOI, Sungjin, LEE, Jongil, IGAWA, Kazuyo, LIU, I-Li, HONNAMI, Muneki, SUZUKI, Shigeki, NISHIMURA, Ryohei, CHUNG, Ung-Il, SASAKI, Nobuo, MOCHIZUKI, Manabu

“…In this study, we aimed to determine the effect of trehalose coating and the optimal dose of basic fibroblast growth factor (bFGF), an osteoinductive protein,…”
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Identification of oxytetracycline as a chondrogenic compound using a cell-based screening system by Hojo, Hironori, Yano, Fumiko, Ohba, Shinsuke, Igawa, Kazuyo, Nakajima, Keiji, Komiyama, Yuske, Kan, Akinori, Ikeda, Toshiyuki, Yonezawa, Takayuki, Woo, Je-Tae, Takato, Tsuyoshi, Nakamura, Kozo, Kawaguchi, Hiroshi, Chung, Ung-il

“…To effectively treat degenerative joint diseases including osteoarthritis (OA), small chemical compounds need to be developed that can potently induce…”
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Tailor-made tricalcium phosphate bone implant directly fabricated by a three-dimensional ink-jet printer by Igawa, Kazuyo, Mochizuki, Manabu, Sugimori, Osamu, Shimizu, Koutaro, Yamazawa, Kenji, Kawaguchi, Hiroshi, Nakamura, Kozo, Takato, Tsuyoshi, Nishimura, Ryouhei, Suzuki, Shigeki, Anzai, Masahiro, Chung, Ung-il, Sasaki, Nobuo

“…Rapid prototyping (RP) is a molding technique that builds a three-dimensional (3D) model from computer-aided design (CAD) data. We fabricated new tailor-made…”
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Mechanism of osteogenic induction by FK506 via BMP/Smad pathways by Kugimiya, Fumitaka, Yano, Fumiko, Ohba, Shinsuke, Igawa, Kazuyo, Nakamura, Kozo, Kawaguchi, Hiroshi, Chung, Ung-il

“…FK506 is an immunosuppressant that exerts effects by binding to FK506-binding protein 12 (FKBP12). Recently, FK506 has also been reported to promote osteogenic…”
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Effect of Trehalose Coating on Basic Fibroblast Growth Factor Release from Tailor-Made Bone Implants by CHOI, Sungjin, LEE, Jongil, IGAWA, Kazuyo, SUZUKI, Shigeki, MOCHIZUKI, Manabu, NISHIMURA, Ryohei, CHUNG, Ung-il, SASAKI, Nobuo

“…Artificial bone implants are often incorporated with osteoinductive factors to facilitate early bone regeneration. Calcium phosphate, the main component in…”
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Comparison of the long-term effects on rabbit bone defects between Tetrabone® and β-tricalcium phosphate granules implantation by Choi, Sungjin, Liu, I-Li, Yamamoto, Kenichi, Honnami, Muneki, Ohba, Shinsuke, Echigo, Ryosuke, Sakai, Takamasa, Igawa, Kazuyo, Suzuki, Shigeki, Nishimura, Ryouhei, Chung, Ung-il, Sasaki, Nobuo, Mochizuki, Manabu

“…Tetrabone ® is a newly developed granular artificial bone. The 1-mm Tetrabone ® has a four-legged structure. In this study, the long-term effect of implanting…”
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Clinical application of artificial bone in the maxillofacial region by Saijo, Hideto, Chung, Ung-il, Igawa, Kazuyo, Mori, Yoshiyuki, Chikazu, Daichi, Iino, Mitsuyoshi, Takato, Tsuyoshi

“…Hard tissue reconstruction is very useful for bony defects of the maxillofacial region. Autogenous bone, allogeneic bone, and artificial bone have been used to…”
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Development of high-throughput screening system for osteogenic drugs using a cell-based sensor by Hojo, Hironori, Igawa, Kazuyo, Ohba, Shinsuke, Yano, Fumiko, Nakajima, Keiji, Komiyama, Yuske, Ikeda, Toshiyuki, Lichtler, Alexander C, Woo, Je-Tae, Yonezawa, Takayuki, Takato, Tsuyoshi, Chung, Ung-il

“…To effectively treat osteoporosis and other bone-loss disorders, small compounds that potently induce bone formation are needed. The present study initially…”
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