Search Results - "Igarashi, Ikuo"

Animal models of the immunology and pathogenesis of human babesiosis by Kumar, Abhinav, Kabra, Aditya, Igarashi, Ikuo, Krause, Peter J.

“…Animal models of human babesiosis have provided a basic understanding of the immunological mechanisms that clear, or occasionally exacerbate, Babesia infection…”
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Assay methods for in vitro and in vivo anti-Babesia drug efficacy testing: Current progress, outlook, and challenges by Rizk, Mohamed Abdo, El-Sayed, Shimaa Abd El-Salam, Nassif, Medhat, Mosqueda, Juan, Xuan, Xuenan, Igarashi, Ikuo

“…•Babesiosis: A disease of veterinary importance with an empty drug pipeline.•There is a wide gap in the treatment of animal babesiosis.•Empty anti-Babesia drug…”
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Discovering the in vitro potent inhibitors against Babesia and Theileria parasites by repurposing the Malaria Box: A review by Rizk, Mohamed Abdo, El-Sayed, Shimaa Abd El-Salam, El-Khodery, Sabry, Yokoyama, Naoaki, Igarashi, Ikuo

“…There is an innovative approach to discovering and developing novel potent and safe anti-Babesia and anti-Theileria agents for the control of animal…”
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Safety and efficacy of hydroxyurea and eflornithine against most blood parasites Babesia and Theileria by El-Saber Batiha, Gaber, Magdy Beshbishy, Amany, Stephen Adeyemi, Oluyomi, Nadwa, Eman, Rashwan, Eman, Yokoyama, Naoaki, Igarashi, Ikuo

“…The plenteous resistance to and undesirable consequences of the existing antipiroplasmic therapies have emphasized the urgent need for new chemotherapeutics…”
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Tafenoquine Is a Promising Drug Candidate for the Treatment of Babesiosis by Liu, Mingming, Ji, Shengwei, Kondoh, Daisuke, Galon, Eloiza May, Li, Jixu, Tomihari, Mizuki, Yanagawa, Masashi, Tagawa, Michihito, Adachi, Mami, Asada, Masahito, Igarashi, Ikuo, Iguchi, Aiko, Xuan, Xuenan

“…Due to drug resistance, commonly used anti- drugs have limited efficacy against babesiosis and inflict severe side effects. Tafenoquine (TAF) was approved by…”
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Evaluation of the inhibitory effect of Zingiber officinale rhizome on Babesia and Theileria parasites by Rizk, Mohamed Abdo, El-Sayed, Shimaa Abd El-Salam, Igarashi, Ikuo

“…The effect of Zingiber officinale rhizome methanolic extract (ZOR) on the in vitro growth of bovine Babesia (B. bovis, B. bigemina, and B. divergens) and…”
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In Vitro Inhibitory Effects and Bioinformatic Analysis of Norfloxacin and Ofloxacin on Piroplasm by Rizk, Mohamed Abdo, El-Sayed, Shimaa Abd El-Salam, Igarashi, Ikuo

“…Purpose The in vitro inhibitory effect of two fluroquinolone antibiotics, norfloxacin and ofloxacin, was evaluated in this study on the growth of several…”
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Development of a stable transgenic Theileria equi parasite expressing an enhanced green fluorescent protein/blasticidin S deaminase by Tuvshintulga, Bumduuren, Nugraha, Arifin Budiman, Mizutani, Tomoka, Liu, Mingming, Ishizaki, Takahiro, Sivakumar, Thillaiampalam, Xuan, Xuenan, Yokoyama, Naoaki, Igarashi, Ikuo

“…Theileria equi , an intraerythrocytic protozoan parasite, causes equine piroplasmosis, a disease which negatively impacts the global horse industry. Genetic…”
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Ellagic acid microspheres restrict the growth of Babesia and Theileria in vitro and Babesia microti in vivo by Beshbishy, Amani Magdy, Batiha, Gaber El-Saber, Yokoyama, Naoaki, Igarashi, Ikuo

“…There are no effective vaccines against Babesia and Theileria parasites; therefore, therapy depends heavily on antiprotozoal drugs. Treatment options for…”
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In vivo activity and atom pair fingerprint analysis of MMV665941 against the apicomplexan parasite Babesia microti, the causative agent of babesiosis in humans and rodents by Rizk, Mohamed Abdo, El-Sayed, Shimaa Abd El-Salam, Igarashi, Ikuo

“…The effect of MMV665941 on the growth of Babesia microti (B. microti) in mice, was investigated in this study using a fluorescence-based SYBR Green I test…”
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Phytochemical Screening and Antiprotozoal Effects of the Methanolic Berberis vulgaris and Acetonic Rhus coriaria Extracts by Batiha, Gaber El-Saber, Magdy Beshbishy, Amany, Adeyemi, Oluyomi Stephen, Nadwa, Eman Hassan, Rashwan, Eman Kadry Mohamed, Alkazmi, Luay M, Elkelish, Amr A, Igarashi, Ikuo

“…( ) and Rhus coriaria (R. coriaria) have been documented to have various pharmacologic activities. The current study assessed the in vitro as well as in vivo…”
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Development of a promising antigenic cocktail for the global detection of Babesia caballi in horse by ELISA by El-Sayed, Shimaa Abd El-Salam, Rizk, Mohamed Abdo, Baghdadi, Hanadi B, Ringo, Aaron Edmond, Sambuu, Gantuya, Nugraha, Arifin Budiman, Igarashi, Ikuo

“…In this study, we designed novel truncated Babesia caballi (B. caballi) recombinant proteins from the previously used B. caballi proteins; 134-Kilodalton…”
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Evaluation of the in vitro and in vivo inhibitory effect of thymoquinone on piroplasm parasites by El-Sayed, Shimaa Abd El-Salam, Rizk, Mohamed Abdo, Yokoyama, Naoaki, Igarashi, Ikuo

“…Developing new antibabesial drugs with a low toxic effect to the animal and with no resistance from Babesia parasites is in urgent demand. In this concern, the…”
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Combination of Clofazimine and Atovaquone as a Potent Therapeutic Regimen for the Radical Cure of Babesia microti Infection in Immunocompromised Hosts by Tuvshintulga, Bumduuren, Sivakumar, Thillaiampalam, Nugraha, Arifin Budiman, Ahedor, Believe, Batmagnai, Enkhbaatar, Otgonsuren, Davaajav, Liu, MingMing, Xuan, Xuenan, Igarashi, Ikuo, Yokoyama, Naoaki

“…Abstract Human babesiosis caused by Babesia microti can be fatal in immunocompromised patients, and the currently used drugs are often ineffective. A recent…”
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Recombinant methionine aminopeptidase protein of Babesia microti: immunobiochemical characterization as a vaccine candidate against human babesiosis by Munkhjargal, Tserendorj, Yokoyama, Naoaki, Igarashi, Ikuo

“…Human babesiosis is the most important zoonotic protozoan infection in the world. This is the first report of the cloning, expression, purification, and…”
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In vivo antibabesial activity and bioinformatic analysis of compounds derived from the Medicines for Malaria Venture box against Babesia microti by Rizk, Mohamed Abdo, El-Sayed, Shimaa Abd El-Salam, Eltaysh, Rasha, Igarashi, Ikuo

“…•Here we evaluated the inhibitory effects of MMV Malaria Box compounds against the growth of B. microti in mice.•MMV667488 exhibited the highest anti-B…”
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Phytochemical Characterization and Chemotherapeutic Potential of Cinnamomum verum Extracts on the Multiplication of Protozoan Parasites In Vitro and In Vivo by Batiha, Gaber El-Saber, Beshbishy, Amany Magdy, Guswanto, Azirwan, Nugraha, Arifin, Munkhjargal, Tserendorj, M Abdel-Daim, Mohamed, Mosqueda, Juan, Igarashi, Ikuo

“…is a commonly used herbal plant that has several documented properties against various diseases. The existing study evaluated the inhibitory effect of acetonic…”
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Inhibitory effect of allicin on the growth of Babesia and Theileria equi parasites by Salama, Akram Ahmed, AbouLaila, Mahmoud, Terkawi, Mohamad Alaa, Mousa, Ahmed, El-Sify, Ahmed, Allaam, Mahmoud, Zaghawa, Ahmed, Yokoyama, Naoaki, Igarashi, Ikuo

“…Allicin is an active ingredient of garlic that has antibacterial, antifungal, antiviral, and antiprotozoal activity. However, the inhibitory effects of allicin…”
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Imidazo[1,2-a]pyridine: a Highly Potent Therapeutic Agent Clears Piroplasm Infection In Vitro by Rizk, Mohamed Abdo, El-Sayed, Shimaa Abd El-Salam, El-Alfy, El-Sayed, Igarashi, Ikuo

“…Background and Purpose The imidazo[1,2-a] pyridines have huge applications in medicinal chemistry with potent activity against wide spectrum of infectious…”
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Clofazimine, a Promising Drug for the Treatment of Babesia microti Infection in Severely Immunocompromised Hosts by Tuvshintulga, Bumduuren, Vannier, Edouard, Tayebwa, Dickson S, Gantuya, Sambuu, Sivakumar, Thillaiampalam, Guswanto, Azirwan, Krause, Peter J, Yokoyama, Naoaki, Igarashi, Ikuo

“…Abstract Background Persistent and relapsing babesiosis caused by Babesia microti often occurs in immunocompromised patients, and has been associated with…”
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