Search Results - "Ifrah, Norbert"

Addition of gemtuzumab ozogamicin to induction chemotherapy in adult patients with acute myeloid leukaemia: a meta-analysis of individual patient data from randomised controlled trials by Hills, Robert K, DPhil, Castaigne, Sylvie, Prof, Appelbaum, Frederick R, Prof, Delaunay, Jacques, MD, Petersdorf, Stephen, MD, Othus, Megan, PhD, Estey, Elihu H, Prof, Dombret, Hervé, Prof, Chevret, Sylvie, PhD, Ifrah, Norbert, Prof, Cahn, Jean-Yves, Prof, Récher, Christian, Prof, Chilton, Lucy, PhD, Moorman, Anthony V, Prof, Burnett, Alan K, Prof

“…Summary Background Gemtuzumab ozogamicin was the first example of antibody-directed chemotherapy in cancer, and was developed for acute myeloid leukaemia…”
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Rituximab in B-Lineage Adult Acute Lymphoblastic Leukemia by Maury, Sébastien, Chevret, Sylvie, Thomas, Xavier, Heim, Dominik, Leguay, Thibaut, Huguet, Françoise, Chevallier, Patrice, Hunault, Mathilde, Boissel, Nicolas, Escoffre-Barbe, Martine, Hess, Urs, Vey, Norbert, Pignon, Jean-Michel, Braun, Thorsten, Marolleau, Jean-Pierre, Cahn, Jean-Yves, Chalandon, Yves, Lhéritier, Véronique, Beldjord, Kheira, Béné, Marie C, Ifrah, Norbert, Dombret, Hervé

“…The addition of rituximab to every phase of treatment (induction, consolidation, and maintenance) in adults with acute lymphoblastic leukemia improves…”
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Comprehensive mutational profiling of core binding factor acute myeloid leukemia by Duployez, Nicolas, Marceau-Renaut, Alice, Boissel, Nicolas, Petit, Arnaud, Bucci, Maxime, Geffroy, Sandrine, Lapillonne, Hélène, Renneville, Aline, Ragu, Christine, Figeac, Martin, Celli-Lebras, Karine, Lacombe, Catherine, Micol, Jean-Baptiste, Abdel-Wahab, Omar, Cornillet, Pascale, Ifrah, Norbert, Dombret, Hervé, Leverger, Guy, Jourdan, Eric, Preudhomme, Claude

“…Acute myeloid leukemia (AML) with t(8;21) or inv(16) have been recognized as unique entities within AML and are usually reported together as core binding…”
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Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia by Willems, Lise, Jacque, Nathalie, Jacquel, Arnaud, Neveux, Nathalie, Trovati Maciel, Thiago, Lambert, Mireille, Schmitt, Alain, Poulain, Laury, Green, Alexa S., Uzunov, Madalina, Kosmider, Olivier, Radford-Weiss, Isabelle, Moura, Ivan Cruz, Auberger, Patrick, Ifrah, Norbert, Bardet, Valérie, Chapuis, Nicolas, Lacombe, Catherine, Mayeux, Patrick, Tamburini, Jérôme, Bouscary, Didier

“…Cancer cells require nutrients and energy to adapt to increased biosynthetic activity, and protein synthesis inhibition downstream of mammalian target of…”
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Intensified Therapy of Acute Lymphoblastic Leukemia in Adults: Report of the Randomized GRAALL-2005 Clinical Trial by Huguet, Françoise, Chevret, Sylvie, Leguay, Thibaut, Thomas, Xavier, Boissel, Nicolas, Escoffre-Barbe, Martine, Chevallier, Patrice, Hunault, Mathilde, Vey, Norbert, Bonmati, Caroline, Lepretre, Stéphane, Marolleau, Jean-Pierre, Pabst, Thomas, Rousselot, Philippe, Buzyn, Agnès, Cahn, Jean-Yves, Lhéritier, Véronique, Béné, Marie C, Asnafi, Vahid, Delabesse, Eric, Macintyre, Elizabeth, Chalandon, Yves, Ifrah, Norbert, Dombret, Hervé

“…Purpose To evaluate randomly the role of hyperfractionated cyclophosphamide (hyper-C) dose intensification in adults with newly diagnosed Philadelphia…”
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International reference analysis of outcomes in adults with B-precursor Ph-negative relapsed/refractory acute lymphoblastic leukemia by Gökbuget, Nicola, Dombret, Hervè, Ribera, Jose-Maria, Fielding, Adele K, Advani, Anjali, Bassan, Renato, Chia, Victoria, Doubek, Michael, Giebel, Sebastian, Hoelzer, Dieter, Ifrah, Norbert, Katz, Aaron, Kelsh, Michael, Martinelli, Giovanni, Morgades, Mireia, O'Brien, Susan, Rowe, Jacob M, Stieglmaier, Julia, Wadleigh, Martha, Kantarjian, Hagop

“…Adults with relapsed/refractory acute lymphoblastic leukemia have an unfavourable prognosis, which is influenced by disease and patient characteristics. To…”
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IL-34 induces the differentiation of human monocytes into immunosuppressive macrophages. antagonistic effects of GM-CSF and IFNγ by Foucher, Etienne D, Blanchard, Simon, Preisser, Laurence, Garo, Erwan, Ifrah, Norbert, Guardiola, Philippe, Delneste, Yves, Jeannin, Pascale

“…IL-34 is a recently identified cytokine that signals via the M-CSF receptor and promotes monocyte survival. Depending on the environment, monocytes can…”
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Toward a NOTCH1/FBXW7/RAS/PTEN–Based Oncogenetic Risk Classification of Adult T-Cell Acute Lymphoblastic Leukemia: A Group for Research in Adult Acute Lymphoblastic Leukemia Study by TRINQUAND, Amélie, TANGUY-SCHMIDT, Aline, LHERITIER, Véronique, BOND, Jonathan, HUGUET, Françoise, BUZYN, Agnès, LEGUAY, Thibaud, CAHN, Jean-Yves, THOMAS, Xavier, CHALANDON, Yves, DELANNOY, André, BONMATI, Caroline, BEN ABDELALI, Raouf, MAURY, Sebastien, NADEL, Bertrand, MACINTYRE, Elizabeth, IFRAH, Norbert, DOMBRET, Hervé, ASNAFI, Vahid, LAMBERT, Jérôme, BELDJORD, Kheira, LENGLINE, Etienne, DE GUNZBURG, Noémie, PAYET-BORNET, Dominique, LHERMITTE, Ludovic, MOSSAFA, Hossein

“…The Group for Research in Adult Acute Lymphoblastic Leukemia (GRAALL) recently reported a significantly better outcome in T-cell acute lymphoblastic leukemia…”
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Thromboembolism prophylaxis in adult patients with acute lymphoblastic leukemia treated in the GRAALL-2005 study by Orvain, Corentin, Balsat, Marie, Tavernier, Emmanuelle, Marolleau, Jean-Pierre, Pabst, Thomas, Chevallier, Patrice, de Gunzburg, Noémie, Cacheux, Victoria, Huguet, Françoise, Chantepie, Sylvain, Caillot, Denis, Chalandon, Yves, Frayfer, Jamilé, Bonmati, Caroline, Lheritier, Véronique, Ifrah, Norbert, Dombret, Hervé, Boissel, Nicolas, Hunault-Berger, Mathilde

“…Patients undergoing treatment of acute lymphoblastic leukemia (ALL) are at risk for thrombosis, caused in part by the use of l-asparaginase (L-ASP)…”
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Clonal interference of signaling mutations worsens prognosis in core-binding factor acute myeloid leukemia by Itzykson, Raphael, Duployez, Nicolas, Fasan, Annette, Decool, Gauthier, Marceau-Renaut, Alice, Meggendorfer, Manja, Jourdan, Eric, Petit, Arnaud, Lapillonne, Hélène, Micol, Jean-Baptiste, Cornillet-Lefebvre, Pascale, Ifrah, Norbert, Leverger, Guy, Dombret, Hervé, Boissel, Nicolas, Haferlach, Torsten, Preudhomme, Claude

“…Mutations in receptor tyrosine kinase/RAS signaling pathway genes are frequent in core-binding factor (CBF) acute myeloid leukemias (AMLs), but their…”
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Pediatric-Inspired Therapy in Adults With Philadelphia Chromosome–Negative Acute Lymphoblastic Leukemia: The GRAALL-2003 Study by HUGUET, Francoise, LEGUAY, Thibaut, VERNANT, Jean-Paul, LAFAGE-POCHITALOFF, Marina, CHASSEVENT, Agnès, LHERITIER, Véronique, MACINTYRE, Elizabeth, BENE, Marie-Christine, IFRAH, Norbert, DOMBRET, Hervé, RAFFOUX, Emmanuel, THOMAS, Xavier, BELDJORD, Kheira, DELABESSE, Eric, CHEVALLIER, Patrice, BUZYN, Agnes, DELANNOY, André, CHALANDON, Yves

“…Retrospective comparisons have suggested that adolescents or teenagers with acute lymphoblastic leukemia (ALL) benefit from pediatric rather than adult…”
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DNMT3A mutation is associated with increased age and adverse outcome in adult T-cell acute lymphoblastic leukemia by Bond, Jonathan, Touzart, Aurore, Leprêtre, Stéphane, Graux, Carlos, Bargetzi, Mario, Lhermitte, Ludovic, Hypolite, Guillaume, Leguay, Thibaut, Hicheri, Yosr, Guillerm, Gaëlle, Bilger, Karin, Lhéritier, Véronique, Hunault, Mathilde, Huguet, Françoise, Chalandon, Yves, Ifrah, Norbert, Macintyre, Elizabeth, Dombret, Hervé, Asnafi, Vahid, Boissel, Nicolas

“…The prognostic implications of genotype in T-cell acute lymphoblastic leukemia are incompletely understood. We performed comprehensive genetic and…”
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Prospective long-term minimal residual disease monitoring using RQ-PCR in RUNX1-RUNX1T1-positive acute myeloid leukemia: results of the French CBF-2006 trial by Willekens, Christophe, Blanchet, Odile, Renneville, Aline, Cornillet-Lefebvre, Pascale, Pautas, Cécile, Guieze, Romain, Ifrah, Norbert, Dombret, Hervé, Jourdan, Eric, Preudhomme, Claude, Boissel, Nicolas

“…In t(8;21)(q22;q22) acute myeloid leukemia, the prognostic value of early minimal residual disease assessed with real-time quantitative polymerase chain…”
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Adult T-cell acute lymphoblastic leukemias with IL7R pathway mutations are slow-responders who do not benefit from allogeneic stem-cell transplantation by Kim, Rathana, Boissel, Nicolas, Touzart, Aurore, Leguay, Thibaut, Thonier, Florian, Thomas, Xavier, Raffoux, Emmanuel, Huguet, Françoise, Villarese, Patrick, Fourrage, Cécile, Passini, Loïc, Hunault, Mathilde, Lepretre, Stéphane, Chevallier, Patrice, Braun, Thorsten, Lhéritier, Véronique, Chantepie, Sylvain, Maury, Sébastien, Escoffre, Martine, Tavernier, Emmanuelle, Chalandon, Yves, Graux, Carlos, Macintyre, Elizabeth, Ifrah, Norbert, Asnafi, Vahid, Dombret, Hervé, Lhermitte, Ludovic

“…The prognostic value of IL7-receptor pathway (IL7Rp) mutations in T-cell acute lymphoblastic leukemia (T-ALL) remains unclear. We performed a comprehensive…”
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The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation by Green, Alexa S., Chapuis, Nicolas, Trovati Maciel, Thiago, Willems, Lise, Lambert, Mireille, Arnoult, Christophe, Boyer, Olivier, Bardet, Valerie, Park, Sophie, Foretz, Marc, Viollet, Benoit, Ifrah, Norbert, Dreyfus, François, Hermine, Olivier, Cruz Moura, Ivan, Lacombe, Catherine, Mayeux, Patrick, Bouscary, Didier, Tamburini, Jerome

“…Finding an effective treatment for acute myeloid leukemia (AML) remains a challenge, and all cellular processes that are deregulated in AML cells should be…”
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Protein synthesis is resistant to rapamycin and constitutes a promising therapeutic target in acute myeloid leukemia by Tamburini, Jerome, Green, Alexa S., Bardet, Valerie, Chapuis, Nicolas, Park, Sophie, Willems, Lise, Uzunov, Madalina, Ifrah, Norbert, Dreyfus, François, Lacombe, Catherine, Mayeux, Patrick, Bouscary, Didier

“…The deregulation of translation markedly contributes to the malignant phenotype in cancers, and the assembly of the translation initiating complex eIF4F is the…”
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Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: rationale for therapeutic inhibition of both pathways by Tamburini, Jerome, Chapuis, Nicolas, Bardet, Valérie, Park, Sophie, Sujobert, Pierre, Willems, Lise, Ifrah, Norbert, Dreyfus, François, Mayeux, Patrick, Lacombe, Catherine, Bouscary, Didier

“…The phosphatidylinositol 3-kinase (PI3K)/Akt and mTORC1 pathways are frequently activated, representing potential therapeutic targets in acute myeloid leukemia…”
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Dual Inhibition of PI3K and mTORC1/2 Signaling by NVP-BEZ235 as a New Therapeutic Strategy for Acute Myeloid Leukemia by CHAPUIS, Nicolas, TAMBURINI, Jerome, MAIRA, Sauveur-Michel, IFRAH, Norbert, DREYFUS, François, HERAULT, Olivier, LACOMBE, Catherine, MAYEUX, Patrick, BOUSCARY, Didier, GREEN, Alexa S, VIGNON, Christine, BARDET, Valerie, NEYRET, Aymeric, PANNETIER, Melanie, WILLEMS, Lise, PARK, Sophie, MACONE, Alexandre

“…The growth and survival of acute myeloid leukemia (AML) cells are enhanced by the deregulation of signaling pathways such as phosphoinositide 3-kinase…”
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Harnessing the MYB-dependent TAL1 5'super-enhancer for targeted therapy in T-ALL by Smith, Charlotte, Touzart, Aurore, Simonin, Mathieu, Tran-Quang, Christine, Hypolite, Guillaume, Latiri, Mehdi, Andrieu, Guillaume P, Balducci, Estelle, Dourthe, Marie-Émilie, Goyal, Ashish, Huguet, Françoise, Petit, Arnaud, Ifrah, Norbert, Baruchel, André, Dombret, Hervé, Macintyre, Elizabeth, Plass, Christoph, Ghysdael, Jacques, Boissel, Nicolas, Asnafi, Vahid

“…The acquisition of genetic abnormalities engendering oncogene dysregulation underpins cancer development. Certain proto-oncogenes possess several dysregulation…”
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Clinico-biological features of T-cell acute lymphoblastic leukemia with fusion proteins by Steimlé, Thomas, Dourthe, Marie-Emilie, Alcantara, Marion, Touzart, Aurore, Simonin, Mathieu, Mondesir, Johanna, Lhermitte, Ludovic, Bond, Jonathan, Graux, Carlos, Grardel, Nathalie, Cayuela, Jean-Michel, Arnoux, Isabelle, Gandemer, Virginie, Balsat, Marie, Vey, Norbert, Macintyre, Elizabeth, Ifrah, Norbert, Dombret, Hervé, Petit, Arnaud, Baruchel, André, Ruminy, Philippe, Boissel, Nicolas, Asnafi, Vahid

“…T-cell acute lymphoblastic leukemias (T-ALL) represent 15% of pediatric and 25% of adult ALL. Since they have a particularly poor outcome in…”
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