Search Results - "Iffland, H."

Focal Cortical Dysplasia: Gene Mutations, Cell Signaling, and Therapeutic Implications by Iffland, Philip H, Crino, Peter B

“…Focal cortical dysplasias (FCDs) are malformations of cortical development (MCDs) that are highly associated with medication-resistant epilepsy and are the…”
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GATORopathies: The role of amino acid regulatory gene mutations in epilepsy and cortical malformations by Iffland, Philip H., Carson, Vincent, Bordey, Angelique, Crino, Peter B.

“…The mechanistic target of rapamycin (mTOR) pathway has been implicated in a growing number of malformations of cortical development (MCD) associated with…”
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DEPDC5 and NPRL3 modulate cell size, filopodial outgrowth, and localization of mTOR in neural progenitor cells and neurons by Iffland, Philip H., Baybis, Marianna, Barnes, Allan E., Leventer, Richard J., Lockhart, Paul J., Crino, Peter B.

“…Mutations in DEPDC5 and NPRL3 subunits of GATOR1, a modulator of mechanistic target of rapamycin (mTOR), are linked to malformations of cortical development…”
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NPRL3 loss alters neuronal morphology, mTOR localization, cortical lamination and seizure threshold by Iffland, Philip H, Everett, Mariah E, Cobb-Pitstick, Katherine M, Bowser, Lauren E, Barnes, Allan E, Babus, Janice K, Romanowski, Andrea J, Baybis, Marianna, Elziny, Soad, Puffenberger, Erik G, Gonzaga-Jauregui, Claudia, Poulopoulos, Alexandros, Carson, Vincent J, Crino, Peter B

“…Mutations in nitrogen permease regulator-like 3 (NPRL3), a component of the GATOR1 complex within the mTOR pathway, are associated with epilepsy and…”
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A role for inflammation in status epilepticus is revealed by a review of current therapeutic approaches by Janigro, Damir, Iffland II, Philip H., Marchi, Nicola, Granata, Tiziana

“…Summary A significant number of patients with epilepsy fail to respond to currently available antiepileptic drugs. This suggests a need for alternative…”
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BK channel properties correlate with neurobehavioral severity in three KCNMA1 -linked channelopathy mouse models by Park, Su Mi, Roache, Cooper E, Iffland, 2nd, Philip H, Moldenhauer, Hans J, Matychak, Katia K, Plante, Amber E, Lieberman, Abby G, Crino, Peter B, Meredith, Andrea

“…KCNMA1 forms the pore of BK K channels, which regulate neuronal and muscle excitability. Recently, genetic screening identified heterozygous variants in a…”
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The role of somatic mutational events in the pathogenesis of epilepsy by Iffland, 2nd, Philip H, Crino, Peter B

“…There has been rapid progress in defining novel causative gene variants responsible for a large spectrum of human epilepsy syndromes and subtypes. Of…”
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A Novel Model to Explain Extreme Feather Pecking Behavior in Laying Hens by Iffland, H., Wellmann, R., Preuß, S., Tetens, J., Bessei, W., Piepho, H.-P., Bennewitz, J.

“…Feather pecking (FP) is a serious economic and welfare problem in the domestic fowl. It has recently been shown that the distribution of FP bouts within groups…”
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Quantitative genetic analysis of causal relationships among feather pecking, feather eating, and general locomotor activity in laying hens using structural equation models by Lutz, V., Kjaer, J. B., Iffland, H., Rodehutscord, M., Bessei, W., Bennewitz, J.

“…The objective of this research was to analyze the relationship between feather pecking (FP) and feather eating (FE) as well as general locomotor activity (GLA)…”
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Dynamic analysis of 4E-BP1 phosphorylation in neurons with Tsc2 or Depdc5 knockout by Iffland, Philip H., Barnes, Allan E., Baybis, Marianna, Crino, Peter B.

“…TSC1 or TSC2 mutations cause Tuberous Sclerosis Complex (TSC), and lead to mechanistic target of rapamycin (mTOR) hyperactivation evidenced by…”
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Viral expression of constitutively active AKT3 induces CST axonal sprouting and regeneration, but also promotes seizures by Campion, Thomas J., Sheikh, Imran S., Smit, Rupert D., Iffland, Philip H., Chen, Jie, Junker, Ian P., Krynska, Barbara, Crino, Peter B., Smith, George M.

“…Increasing the intrinsic growth potential of neurons after injury has repeatedly been shown to promote some level of axonal regeneration in rodent models. One…”
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Intracellular and circulating neuronal antinuclear antibodies in human epilepsy by Iffland, Philip H, Carvalho-Tavares, Juliana, Trigunaite, Abhishek, Man, Shumei, Rasmussen, Peter, Alexopoulos, Andreas, Ghosh, Chaitali, Jørgensen, Trine N, Janigro, Damir

“…Abstract There are overwhelming data supporting the inflammatory origin of some epilepsies ( e.g. , Rasmussen's encephalitis and limbic encephalitis)…”
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Multimodal Analysis of STRADA Function in Brain Development by Dang, Louis T, Glanowska, Katarzyna M, Iffland Ii, Philip H, Barnes, Allan E, Baybis, Marianna, Liu, Yu, Patino, Gustavo, Vaid, Shivanshi, Streicher, Alexandra M, Parker, Whitney E, Kim, Seonhee, Moon, Uk Yeol, Henry, Frederick E, Murphy, Geoffrey G, Sutton, Michael, Parent, Jack M, Crino, Peter B

“…mTORopathies are a heterogeneous group of neurological disorders characterized by malformations of cortical development (MCD), enhanced cellular mechanistic…”
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Anti-NR2 antibodies, blood-brain barrier, and cognitive dysfunction by Gulati, Gaurav, Iffland, Philip H., Janigro, Damir, Zhang, Bin, Luggen, Michael E.

“…Cognitive dysfunction (CD) is one of the most common neuropsychiatric manifestations of systemic lupus erythematosus (SLE). In animal models, antibodies to NR2…”
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Sending Mixed Signals: The Expanding Role of Molecular Cascade Mutations in Malformations of Cortical Development and Epilepsy by Iffland, Philip H., Crino, Peter B.

“…Advances in gene sequencing techniques have led to a dramatic increase in the number of signaling cascade and cytoskeletal assembly mutations associated with…”
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Models of KPTN-related disorder implicate mTOR signalling in cognitive and overgrowth phenotypes by Levitin, Maria O, Rawlins, Lettie E, Sanchez-Andrade, Gabriela, Arshad, Osama A, Collins, Stephan C, Sawiak, Stephen J, Iffland, Phillip H, Andersson, Malin H L, Bupp, Caleb, Cambridge, Emma L, Coomber, Eve L, Ellis, Ian, Herkert, Johanna C, Ironfield, Holly, Jory, Logan, Kretz, Perrine F, Kant, Sarina G, Neaverson, Alexandra, Nibbeling, Esther, Rowley, Christine, Relton, Emily, Sanderson, Mark, Scott, Ethan M, Stewart, Helen, Shuen, Andrew Y, Schreiber, John, Tuck, Liz, Tonks, James, Terkelsen, Thorkild, van Ravenswaaij-Arts, Conny, Vasudevan, Pradeep, Wenger, Olivia, Wright, Michael, Day, Andrew, Hunter, Adam, Patel, Minal, Lelliott, Christopher J, Crino, Peter B, Yalcin, Binnaz, Crosby, Andrew H, Baple, Emma L, Logan, Darren W, Hurles, Matthew E, Gerety, Sebastian S

“…Abstract KPTN-related disorder is an autosomal recessive disorder associated with germline variants in KPTN (previously known as kaptin), a component of the…”
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Clinical evaluation of the effect of an ultrasonic toothbrush on plaque, gingivitis, and gingival bleeding: A six-month study by Terezhalmy, G.T., Iffland, H., Jelepis, C., Waskowski, J.

“…This study evaluated the long-term effect of an ultrasonic toothbrush used as part of a daily oral hygiene regimen on supragingival plaque, gingivitis, and…”
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Radiotherapy and oral sequelae: preventive and management protocols by Whitmyer, C C, Waskowski, J C, Iffland, H A

“…The purpose of this paper is to provide background information on radiotherapy, and to present dental hygiene protocols for the treatment of head and neck…”
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GATOR opathies: The role of amino acid regulatory gene mutations in epilepsy and cortical malformations by Iffland, Philip H., Carson, Vincent, Bordey, Angelique, Crino, Peter B.

“…Abstract The mechanistic target of rapamycin (mTOR) pathway has been implicated in a growing number of malformations of cortical development (MCD) associated…”
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What doesn't kill you makes you stronger: The paradoxical effect of antibodies in epilepsy by Iffland, Philip H

“…Many types of epilepsy, autoimmune or otherwise, are associated with the presence of autoantibodies against neuronal proteins. Paradoxically, antibodies (IVIg)…”
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