Search Results - "Ifat Abramovich"

Metabolic adaptation to consume butyrate under prolonged resource exhaustion by Katz, Sophia, Grajeda-Iglesias, Claudia, Agranovich, Bella, Ghrayeb, Alia, Abramovich, Ifat, Hilau, Sabrin, Gottlieb, Eyal, Hershberg, Ruth

“…Bacteria must often survive following the exhaustion of their external growth resources. Fitting with this need, many bacterial species that cannot sporulate,…”
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SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα by Naiman, Shoshana, Huynh, Frank K., Gil, Reuven, Glick, Yair, Shahar, Yael, Touitou, Noga, Nahum, Liat, Avivi, Matan Y., Roichman, Asael, Kanfi, Yariv, Gertler, Asaf A., Doniger, Tirza, Ilkayeva, Olga R., Abramovich, Ifat, Yaron, Orly, Lerrer, Batia, Gottlieb, Eyal, Harris, Robert A., Gerber, Doron, Hirschey, Matthew D., Cohen, Haim Y.

“…The pro-longevity enzyme SIRT6 regulates various metabolic pathways. Gene expression analyses in SIRT6 heterozygotic mice identify significant decreases in…”
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Circulating succinate-modifying metabolites accurately classify and reflect the status of fumarate hydratase-deficient renal cell carcinoma by Zheng, Liang, Zhu, Zi-Ran, Sneh, Tal, Zhang, Wei-Tuo, Wang, Zao-Yu, Wu, Guang-Yu, He, Wei, Qi, Hong-Gang, Wang, Hang, Wu, Xiao-Yu, Fernández-García, Jonatan, Abramovich, Ifat, Xu, Yun-Ze, Zhang, Jin, Gottlieb, Eyal

“…Germline or somatic loss-of-function mutations of fumarate hydratase (FH) predispose patients to an aggressive form of renal cell carcinoma (RCC). Since other…”
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Host autophagy mediates organ wasting and nutrient mobilization for tumor growth by Khezri, Rojyar, Holland, Petter, Schoborg, Todd Andrew, Abramovich, Ifat, Takáts, Szabolcs, Dillard, Caroline, Jain, Ashish, O'Farrell, Fergal, Schultz, Sebastian Wolfgang, Hagopian, William M, Quintana, Eduardo Martin, Ng, Rachel, Katheder, Nadja Sandra, Rahman, Mohammed Mahidur, Teles Reis, José Gerardo, Brech, Andreas, Jasper, Heinrich, Rusan, Nasser M, Jahren, Anne Hope, Gottlieb, Eyal, Rusten, Tor Erik

“…During tumor growth—when nutrient and anabolic demands are high—autophagy supports tumor metabolism and growth through lysosomal organelle turnover and…”
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Failure to mate enhances investment in behaviors that may promote mating reward and impairs the ability to cope with stressors via a subpopulation of Neuropeptide F receptor neurons by Ryvkin, Julia, Omesi, Liora, Kim, Yong-Kyu, Levi, Mali, Pozeilov, Hadar, Barak-Buchris, Lital, Agranovich, Bella, Abramovich, Ifat, Gottlieb, Eyal, Jacob, Avi, Nässel, Dick R, Heberlein, Ulrike, Shohat-Ophir, Galit

“…Living in dynamic environments such as the social domain, where interaction with others determines the reproductive success of individuals, requires the…”
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Bioenergetic and Metabolic Impairments in Induced Pluripotent Stem Cell-Derived Cardiomyocytes Generated from Duchenne Muscular Dystrophy Patients by Willi, Lubna, Abramovich, Ifat, Fernandez-Garcia, Jonatan, Agranovich, Bella, Shulman, Margarita, Milman, Helena, Baskin, Polina, Eisen, Binyamin, Michele, Daniel E., Arad, Michael, Binah, Ofer, Gottlieb, Eyal

“…Duchenne muscular dystrophy (DMD) is caused by mutations in the dystrophin gene and dilated cardiomyopathy (DCM) is a major cause of morbidity and mortality in…”
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Systemic hypoxia inhibits T cell response by limiting mitobiogenesis via matrix substrate-level phosphorylation arrest by Saragovi, Amijai, Abramovich, Ifat, Omar, Ibrahim, Arbib, Eliran, Toker, Ori, Gottlieb, Eyal, Berger, Michael

“…Systemic oxygen restriction (SOR) is prevalent in numerous clinical conditions, including chronic obstructive pulmonary disease (COPD), and is associated with…”
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Cellular and metabolic characteristics of pre-leukemic hematopoietic progenitors with GATA2 haploinsufficiency by Rein, Avigail, Geron, Ifat, Kugler, Eitan, Fishman, Hila, Gottlieb, Eyal, Abramovich, Ifat, Giladi, Amir, Amit, Ido, Mulet-Lazaro, Roger, Delwel, Ruud, Gröschel, Stefan, Levin-Zaidman, Smadar, Dezorella, Nili, Holdengreber, Vered, Rao, Tata Nageswara, Yacobovich, Joanne, Steinberg-Shemer, Orna, Huang, Qiu-Hua, Tan, Yun, Chen, Sai-Juan, Izraeli, Shai, Birger, Yehudit

“…Mono-allelic germline disruptions of the transcription factor GATA2 result in a propensity for developing myelodysplastic syndrome (MDS) and acute myeloid…”
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Kidney Proximal Tubule GLUT2-More than Meets the Eye by Ahmad, Majdoleen, Abramovich, Ifat, Agranovich, Bella, Nemirovski, Alina, Gottlieb, Eyal, Hinden, Liad, Tam, Joseph

“…Tubulopathy plays a central role in the pathophysiology of diabetic kidney disease (DKD). Under diabetic conditions, the kidney proximal tubule cells (KPTCs)…”
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Physiological impact of in vivo stable isotope tracing on cancer metabolism by Grima-Reyes, Manuel, Martinez-Turtos, Adriana, Abramovich, Ifat, Gottlieb, Eyal, Chiche, Johanna, Ricci, Jean-Ehrland

“…There is growing interest in the analysis of tumor metabolism to identify cancer-specific metabolic vulnerabilities and therapeutic targets. Finding of such…”
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Glutamine Homeostasis and Its Role in the Adaptive Strategies of the Blind Mole Rat, Spalax by Miskevich, Dmitry, Chaban, Anastasia, Dronina, Maria, Abramovich, Ifat, Gottlieb, Eyal, Shams, Imad

“…Oxidative metabolism is fine-tuned machinery that combines two tightly coupled fluxes of glucose and glutamine-derived carbons. Hypoxia interrupts the…”
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Genetically engineering glycolysis in T cells increases their antitumor function by Toledano Zur, Raphaëlle, Atar, Orna, Barliya, Tilda, Hoogi, Shiran, Abramovich, Ifat, Gottlieb, Eyal, Ron-Harel, Noga, Cohen, Cyrille J

“…BackgroundT cells play a central role in the antitumor response. However, they often face numerous hurdles in the tumor microenvironment, including the…”
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Mapping the metabolic reprogramming induced by sodium-glucose cotransporter 2 inhibition by Kogot-Levin, Aviram, Riahi, Yael, Abramovich, Ifat, Mosenzon, Ofri, Agranovich, Bella, Kadosh, Liat, Ben-Haroush Schyr, Rachel, Kleiman, Doron, Hinden, Liad, Cerasi, Erol, Ben-Zvi, Danny, Bernal-Mizrachi, Ernesto, Tam, Joseph, Gottlieb, Eyal, Leibowitz, Gil

“…Diabetes is associated with increased risk for kidney disease, heart failure, and mortality. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) prevent these…”
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Metabolic alterations and cellular responses to β-Hydroxybutyrate treatment in breast cancer cells by Fulman-Levy, Hadas, Cohen-Harazi, Raichel, Levi, Bar, Argaev-Frenkel, Lital, Abramovich, Ifat, Gottlieb, Eyal, Hofmann, Sarah, Koman, Igor, Nesher, Elimelech

“…The ketogenic diet (KD), based on high fat (over 70% of daily calories), low carbohydrate, and adequate protein intake, has become popular due to its potential…”
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Comprehensive Analysis of 13C6 Glucose Fate in the Hypoxia-Tolerant Blind Mole Rat Skin Fibroblasts by Miskevich, Dmitry, Chaban, Anastasia, Dronina, Maria, Abramovich, Ifat, Gottlieb, Eyal, Shams, Imad

“…The bioenergetics of the vast majority of terrestrial mammals evolved to consuming glucose (Glc) for energy production under regular atmosphere (about 21%…”
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Metabolic adaptation of acute lymphoblastic leukemia to the central nervous system microenvironment depends on stearoyl-CoA desaturase by Savino, Angela Maria, Fernandes, Sara Isabel, Olivares, Orianne, Zemlyansky, Anna, Cousins, Antony, Markert, Elke K., Barel, Shani, Geron, Ifat, Frishman, Liron, Birger, Yehudit, Eckert, Cornelia, Tumanov, Sergey, MacKay, Gillian, Kamphorst, Jurre J., Herzyk, Pawel, Fernández-García, Jonatan, Abramovich, Ifat, Mor, Inbal, Bardini, Michela, Barin, Ersilia, Janaki-Raman, Sudha, Cross, Justin R., Kharas, Michael G., Gottlieb, Eyal, Izraeli, Shai, Halsey, Christina

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RAS Regulates the Transition from Naive to Primed Pluripotent Stem Cells by Altshuler, Anna, Verbuk, Mila, Bhattacharya, Swarnabh, Abramovich, Ifat, Haklai, Roni, Hanna, Jacob H., Kloog, Yoel, Gottlieb, Eyal, Shalom-Feuerstein, Ruby

“…The transition from naive to primed state of pluripotent stem cells is hallmarked by epithelial-mesenchymal transition, metabolic switch from oxidative…”
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Differential effects of bariatric surgery and caloric restriction on hepatic one-carbon and fatty acid metabolism by Haran, Arnon, Bergel, Michael, Kleiman, Doron, Hefetz, Liron, Israeli, Hadar, Weksler-Zangen, Sarah, Agranovich, Bella, Abramovich, Ifat, Ben-Haroush Schyr, Rachel, Gottlieb, Eyal, Ben-Zvi, Danny

“…Weight loss interventions, including dietary changes, pharmacotherapy, or bariatric surgery, prevent many of the adverse consequences of obesity, and may also…”
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Selective Recognition of the Higher Alkali Fluoride Ion Pairs by a Class of Coordination-Driven Non-Ditopic Ligands by Almog, Joseph, Gavish-Abramovich, Ifat, Rozin, Rinat, Cohen, Shmuel, Yardeni, Guy, Zilbermann, Israel

“…A first non‐ditopic system for selective recognition and binding of the higher alkali fluorides (KF, RbF, and CsF) is reported. Specific ion‐pair recognition…”
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A metabolic switch to the pentose-phosphate pathway induces radiation resistance in pancreatic cancer by Shimoni-Sebag, Ariel, Abramovich, Ifat, Agranovich, Bella, Massri, Rami, Stossel, Chani, Atias, Dikla, Raites-Gurevich, Maria, Yizhak, Keren, Golan, Talia, Gottlieb, Eyal, Lawrence, Yaacov Richard

“…[Display omitted] •Novel model of radioresistance identified in pancreatic cancer.•Radioresistant PDAC cells display metabolic reprogramming.•Elevated…”
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