Can HLA-DRB4 Help to Identify Asthmatic Patients at Risk of Churg-Strauss Syndrome?

Can HLA-DRB4 Help to Identify Asthmatic Patients at Risk of Churg-Strauss Syndrome?

HLA-DRB4 gene is associated with Churg-Strauss syndrome (CSS), a systemic eosinophilic vasculitis with a prodromal phase characterized by severe asthma, eosinophilia, nasal polyposis, and sinusitis. Aim of this study was to evaluate if the presence of HLA-DRB4 in asthmatic patients is associated wit...

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Bibliographic Details
Published in:ISRN rheumatology Vol. 2014; pp. 843804 - 5
Main Authors: Bottero, P., Motta, F., Bonini, M., Vecchio, F., Ierna, F., Cuppari, I., Sinico, R. A.
Format: Journal Article
Language:English
Published: Egypt Hindawi Publishing Corporation 2014
Hindawi Limited
Subjects:
Allergies
Asthma
Autoimmune diseases
Confidence intervals
Pathogenesis
Online Access:Get full text
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Summary:HLA-DRB4 gene is associated with Churg-Strauss syndrome (CSS), a systemic eosinophilic vasculitis with a prodromal phase characterized by severe asthma, eosinophilia, nasal polyposis, and sinusitis. Aim of this study was to evaluate if the presence of HLA-DRB4 in asthmatic patients is associated with a clinical picture resembling that of the prodromal phase of CSS. HLA-DRB1 was determined in a cohort of 159 asthmatic patients and its frequency was compared with that of 1808 blood donors. HLA-DRB4 presence/absence was correlated with clinical features, including sinusitis, nasal polyposis, eosinophils, antiasthmatic drugs, asthma severity, and pulmonary function tests. HLA-DRB4 gene was associated with severe persistent asthma before treatment (P<0.02), near fatal or severe hypoxemic asthma (P<0.01), sinusitis (P<0.01), nasal polyposis (P<0.01), number of patients with eosinophils >1000/μl: (P<0.05), need of beclomethasone >1000–2000 μg/daily (P<0.001), use of a third controller (P<0.05), and oral prednisone (P<0.02). HLA-DRB4 gene is associated in asthmatic patients with a clinical picture characterized by asthma severity, sinusitis, nasal polyposis, and eosinophilia closely resembling that of the prodromal phase of CSS and might be useful to suspect corticosteroids-masked cases of CSS.
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Academic Editors: M. G. Danieli, P. A. Gatenby, and G. Murdaca
ISSN:2090-5467
2090-5475
2090-5475
DOI:10.1155/2014/843804