Search Results - "Idrizi, Adrian"

Neuronal brain-region-specific DNA methylation and chromatin accessibility are associated with neuropsychiatric trait heritability by Rizzardi, Lindsay F., Hickey, Peter F., Rodriguez DiBlasi, Varenka, Tryggvadóttir, Rakel, Callahan, Colin M., Idrizi, Adrian, Hansen, Kasper D., Feinberg, Andrew P.

“…Epigenetic modifications confer stable transcriptional patterns in the brain, and both normal and abnormal brain function involve specialized brain regions. We…”
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Human brain region-specific variably methylated regions are enriched for heritability of distinct neuropsychiatric traits by Rizzardi, Lindsay F, Hickey, Peter F, Idrizi, Adrian, Tryggvadóttir, Rakel, Callahan, Colin M, Stephens, Kimberly E, Taverna, Sean D, Zhang, Hao, Ramazanoglu, Sinan, Hansen, Kasper D, Feinberg, Andrew P

“…DNA methylation dynamics in the brain are associated with normal development and neuropsychiatric disease and differ across functionally distinct brain…”
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Precision pharmacological reversal of strain-specific diet-induced metabolic syndrome in mice informed by epigenetic and transcriptional regulation by Wulfridge, Phillip, Davidovich, Adam, Salvador, Anna C, Manno, Gabrielle C, Tryggvadottir, Rakel, Idrizi, Adrian, Huda, M Nazmul, Bennett, Brian J, Adams, L Garry, Hansen, Kasper D, Threadgill, David W, Feinberg, Andrew P

“…Diet-related metabolic syndrome is the largest contributor to adverse health in the United States. However, the study of gene-environment interactions and…”
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A Dysregulated DNA Methylation Landscape Linked to Gene Expression in MLL-Rearranged AML by Koldobskiy, Michael A., Abante, Jordi, Jenkinson, Garrett, Pujadas, Elisabet, Tetens, Ashley, Zhao, Feifei, Tryggvadottir, Rakel, Idrizi, Adrian, Reinisch, Andreas, Majeti, Ravindra, Goutsias, John, Feinberg, Andrew P.

“…Translocations of the KMT2A (MLL) gene define a biologically distinct and clinically aggressive subtype of acute myeloid leukaemia (AML), marked by a…”
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Converging genetic and epigenetic drivers of paediatric acute lymphoblastic leukaemia identified by an information-theoretic analysis by Koldobskiy, Michael A., Jenkinson, Garrett, Abante, Jordi, Rodriguez DiBlasi, Varenka A., Zhou, Weiqiang, Pujadas, Elisabet, Idrizi, Adrian, Tryggvadottir, Rakel, Callahan, Colin, Bonifant, Challice L., Rabin, Karen R., Brown, Patrick A., Ji, Hongkai, Goutsias, John, Feinberg, Andrew P.

“…In cancer, linking epigenetic alterations to drivers of transformation has been difficult, in part because DNA methylation analyses must capture epigenetic…”
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Association of DNA Methylation Differences With Schizophrenia in an Epigenome-Wide Association Study by Montano, Carolina, Taub, Margaret A, Jaffe, Andrew, Briem, Eirikur, Feinberg, Jason I, Trygvadottir, Rakel, Idrizi, Adrian, Runarsson, Arni, Berndsen, Birna, Gur, Ruben C, Moore, Tyler M, Perry, Rodney T, Fugman, Doug, Sabunciyan, Sarven, Yolken, Robert H, Hyde, Thomas M, Kleinman, Joel E, Sobell, Janet L, Pato, Carlos N, Pato, Michele T, Go, Rodney C, Nimgaonkar, Vishwajit, Weinberger, Daniel R, Braff, David, Gur, Raquel E, Fallin, Margaret Daniele, Feinberg, Andrew P

“…DNA methylation may play an important role in schizophrenia (SZ), either directly as a mechanism of pathogenesis or as a biomarker of risk. To scan genome-wide…”
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DIPG-42. MAPPING THE DNA METHYLATION LANDSCAPE OF DIPG REVEALS NOTABLE METHYLOME VARIABILITY RESPONSIVE TO PHARMACOLOGIC MODULATION by Tetens, Ashley, Martin, Allison, Arnold, Antje, Novak, Orlandi, Idrizi, Adrian, Tryggvadottir, Rakel, Craig-Schwartz, Jordyn, Barbato, Michael, Eberhart, Charles, Resnick, Adam, Koldobskiy, Michael

“…Abstract Diffuse intrinsic pontine glioma (DIPG) is an incurable pediatric brainstem tumor, driven by the H3K27M mutation leading to epigenetic dysregulation…”
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DIPG-58. TARGETING DISORDERED DNA METHYLATION IN DIPG TO CONSTRAIN VARIABILITY AND INDUCE IMMUNE SIGNALING by Tetens, Ashley R, Martin, Allison M, Arnold, Antje, Novak, Orlandi V, Idrizi, Adrian, Tryggvadottir, Rakel, Craig-Schwartz, Jordyn, Liapodimitri, Athanasia, Lunsford, Kayleigh, Barbato, Michael I, Eberhart, Charles G, Resnick, Adam C, Raabe, Eric H, Koldobskiy, Michael A

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Comprehensive DNA Methylation Analysis Indicates That Pancreatic Intraepithelial Neoplasia Lesions Are Acinar-Derived and Epigenetically Primed for Carcinogenesis by Lo, Emily K W, Mears, Brian M, Maurer, H Carlo, Idrizi, Adrian, Hansen, Kasper D, Thompson, Elizabeth D, Hruban, Ralph H, Olive, Kenneth P, Feinberg, Andrew P

“…Pancreatic ductal adenocarcinoma (PDAC) is believed to arise from the accumulation of a series of somatic mutations and is also frequently associated with…”
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DNA methylation is stable during replication and cell cycle arrest by Vandiver, Amy R., Idrizi, Adrian, Rizzardi, Lindsay, Feinberg, Andrew P., Hansen, Kasper D.

“…DNA methylation is an epigenetic modification with important functions in development. Large-scale loss of DNA methylation is a hallmark of cancer. Recent work…”
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DNA methylation landscapes in DIPG reveal methylome variability that can be modified pharmacologically by Tetens, Ashley R, Martin, Allison M, Arnold, Antje, Novak, Orlandi V, Idrizi, Adrian, Tryggvadottir, Rakel, Craig-Schwartz, Jordyn, Liapodimitri, Athanasia, Lunsford, Kayleigh, Barbato, Michael I, Eberhart, Charles G, Resnick, Adam C, Raabe, Eric H, Koldobskiy, Michael A

“…Abstract Background Diffuse intrinsic pontine glioma (DIPG) is a uniformly lethal brainstem tumor of childhood, driven by histone H3 K27M mutation and…”
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Long-term impacts of disturbance on nitrogen-cycling bacteria in a New England salt marsh by Bernhard, Anne E, Dwyer, Courtney, Idrizi, Adrian, Bender, Geoffrey, Zwick, Rachel

“…Recent studies on the impacts of disturbance on microbial communities indicate communities show differential responses to disturbance, yet our understanding of…”
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An information-theory analysis of DNA methylation identifies converging genetic and epigenetic drivers of paediatric acute lymphoblastic leukaemia by Koldobskiy, Michael A., Jenkinson, Garrett, Abante, Jordi, DiBlasi, Varenka A. Rodriguez, Zhou, Weiqiang, Pujadas, Elisabet, Idrizi, Adrian, Tryggvadottir, Rakel, Callahan, Colin, Bonifant, Challice L., Rabin, Karen R., Brown, Patrick A., Ji, Hongkai, Goutsias, John, Feinberg, Andrew P.

“…In cancer, linking epigenetic alterations to drivers of transformation has been difficult, in part because DNA-methylation analyses must capture epigenetic…”
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