Search Results - "Idris, Aymen"

Emerging therapeutic targets in cancer induced bone disease: A focus on the peripheral type 2 cannabinoid receptor by Marino, Silvia, Idris, Aymen I.

“…[Display omitted] Skeletal complications are a common cause of morbidity in patients with primary bone cancer and bone metastases. The type 2 cannabinoid…”
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TRAF6 as a potential target in advanced breast cancer: a systematic review, meta-analysis, and bioinformatics validation by Zeng, Feier, Carrasco, Giovana, Li, Boya, Sophocleous, Antonia, Idris, Aymen I.

“…TRAF6 has emerged as a key regulator of breast cancer (BCa). However, the TRAF family constitutes of seven members that exhibit distinct and overlapping…”
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Recent Trends and Advances in Cancer-Induced Bone Disease by Idris, Aymen I.

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Association of cannabinoid receptor modulation with normal and abnormal skeletal remodelling: A systematic review and meta-analysis of in vitro, in vivo and human studies by Sophocleous, Antonia, Yiallourides, Michael, Zeng, Feier, Pantelas, Pantelis, Stylianou, Eleni, Li, Boya, Carrasco, Giovana, Idris, Aymen I.

“…To address the inconsistent findings from studies that used different models to explore the role of classical cannabinoid type 1 (CB1) and 2 (CB2) receptors in…”
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Combined deficiency of the Cnr1 and Cnr2 receptors protects against age‐related bone loss by osteoclast inhibition by Sophocleous, Antonia, Marino, Silvia, Kabir, Dilruba, Ralston, Stuart H., Idris, Aymen I.

“…Summary The endocannabinoid system plays a role in regulating bone mass and bone cell activity and inactivation of the type 1 (Cnr1) or type 2 (Cnr2)…”
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Classical cannabinoid receptors as target in cancer-induced bone pain: a systematic review, meta-analysis and bioinformatics validation by Zeng, Feier, Wade, Abbie, Harbert, Kade, Patel, Shrina, Holley, Joshua S., Dehghanpuor, Cornelia K., Hopwood, Thomas, Marino, Silvia, Sophocleous, Antonia, Idris, Aymen I.

“…To test the hypothesis that genetic and pharmacological modulation of the classical cannabinoid type 1 (CB 1 ) and 2 (CB 2 ) receptors attenuate cancer-induced…”
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The TRPV1 ion channel antagonist capsazepine inhibits osteoclast and osteoblast differentiation in vitro and ovariectomy induced bone loss in vivo by Idris, Aymen I, Landao-Bassonga, Euphemie, Ralston, Stuart H

“…Abstract The vanilloid type 1 ion channel (TRPV1) is known to play an important role in the regulation of pain and inflammation. Pharmacological ligands of…”
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Pharmacological Inhibition of NFκB Reduces Prostate Cancer Related Osteoclastogenesis In Vitro and Osteolysis Ex Vivo by Marino, Silvia, Bishop, Ryan T., Carrasco, Giovana, Logan, John G., Li, Boya, Idris, Aymen I.

“…NFκB is implicated in cancer and bone remodelling, and we have recently reported that the verified NFκB inhibitor Parthenolide (PTN) reduced osteolysis and…”
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Pharmacological Inhibition of the Skeletal IKKβ Reduces Breast Cancer-Induced Osteolysis by Marino, Silvia, Bishop, Ryan T., Mollat, Patrick, Idris, Aymen I.

“…IKKβ has previously been implicated in breast cancer bone metastasis and bone remodelling. However, the contribution of IKKβ expressed by bone cells of the…”
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Combined administration of a small-molecule inhibitor of TRAF6 and Docetaxel reduces breast cancer skeletal metastasis and osteolysis by Bishop, Ryan T., Marino, Silvia, Carrasco, Giovana, Li, Boya, Allen, Richard J., Sparatore, Anna, Ottewell, Penelope D., Mollat, Patrick, Sims, Andrew H., Capulli, Mattia, Wang, Ning, Idris, Aymen I.

“…Tumour necrosis factor receptor-associated factor 6 (TRAF6) has been implicated in breast cancer and osteoclastic bone destruction. Here, we report that…”
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Cannabinoid Receptor Type 1 Protects against Age- Related Osteoporosis by Regulating Osteoblast and Adipocyte Differentiation in Marrow Stromal Cells by Idris, Aymen I., Sophocleous, Antonia, Landao-Bassonga, Euphemie, Canals, Meritxell, Milligan, Graeme, Baker, David, van't Hof, Robert J., Ralston, Stuart H.

“…Age-related osteoporosis is characterized by reduced bone formation and accumulation of fat in the bone marrow compartment. Here, we report that the type 1…”
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Anti-inflammatory, but not osteoprotective, effect of the TRAF6/CD40 inhibitor 6877002 in rodent models of local and systemic osteolysis by Marino, Silvia, Hannemann, Nicole, Bishop, Ryan T., Zeng, Feier, Carrasco, Giovana, Meurisse, Sandrine, Li, Boya, Sophocleous, Antonia, Sparatore, Anna, Baeuerle, Tobias, Vukicevic, Slobodan, Auberval, Marielle, Mollat, Patrick, Bozec, Aline, Idris, Aymen I.

“…[Display omitted] NFκB plays a key role in inflammation and skeletal disorders. Previously, we reported that pharmacological inhibition of NFκB at the level of…”
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Regulation of Bone Mass, Osteoclast Function, and Ovariectomy-Induced Bone Loss by the Type 2 Cannabinoid Receptor by Idris, Aymen I, Sophocleous, Antonia, Landao-Bassonga, Euphemie, van't Hof, Robert J, Ralston, Stuart H

“…The endocannabinoid system has recently been shown to play a role in the regulation of bone metabolism. The type 2 cannabinoid receptor (CB2) has been reported…”
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Bone Cell-autonomous Contribution of Type 2 Cannabinoid Receptor to Breast Cancer-induced Osteolysis by Sophocleous, Antonia, Marino, Silvia, Logan, John G., Mollat, Patrick, Ralston, Stuart H., Idris, Aymen I.

“…The cannabinoid type 2 receptor (CB2) has previously been implicated as a regulator of tumor growth, bone remodeling, and bone pain. However, very little is…”
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Role of cannabinoids in the regulation of bone remodeling by Idris, Aymen I, Ralston, Stuart H

“…The endocannabinoid system plays a key role in regulating a variety of physiological processes such as appetite control and energy balance, pain perception,…”
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The Type 2 Cannabinoid Receptor Regulates Bone Mass and Ovariectomy-Induced Bone Loss by Affecting Osteoblast Differentiation and Bone Formation by Sophocleous, Antonia, Landao-Bassonga, Euphemie, van‘t Hof, Robert J, Idris, Aymen I, Ralston, Stuart H

“…The type 2 cannabinoid receptor protects against age-related and ovariectomy-induced bone loss primarily by regulating osteoblast differentiation and bone…”
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JZL184, A Monoacylglycerol Lipase Inhibitor, Induces Bone Loss in a Multiple Myeloma Model of Immunocompetent Mice by Marino, Silvia, Carrasco, Giovana, Li, Boya, Shah, Karan M., Lath, Darren L., Sophocleous, Antonia, Lawson, Michelle A., Idris, Aymen I.

“…Multiple myeloma (MM) patients develop osteolysis characterised by excessive osteoclastic bone destruction and lack of osteoblast bone formation…”
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Pharmacological evidence for the bone-autonomous contribution of the NFκB/β-catenin axis to breast cancer related osteolysis by Marino, Silvia, Bishop, Ryan T., Logan, John G., Mollat, Patrick, Idris, Aymen I.

“…The NFκB signaling pathway is implicated in breast cancer and bone metastasis. However, the bone-autonomous contribution of NFκB to breast cancer-induced…”
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TRAF2 in osteotropic breast cancer cells enhances skeletal tumour growth and promotes osteolysis by Peramuhendige, Prabha, Marino, Silvia, Bishop, Ryan T., de Ridder, Daniëlle, Khogeer, Asim, Baldini, Isabella, Capulli, Mattia, Rucci, Nadia, Idris, Aymen I.

“…NFκB plays an important role in inflammation and bone remodelling. Tumour necrosis factor receptor associated factor 2 (TRAF2), a key component of NFκB…”
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Pharmacological inhibition of the IKKε/TBK-1 axis potentiates the anti-tumour and anti-metastatic effects of Docetaxel in mouse models of breast cancer by Bishop, Ryan T., Marino, Silvia, de Ridder, Daniëlle, Allen, Richard J., Lefley, Diane V., Sims, Andrew H., Wang, Ning, Ottewell, Penelope D., Idris, Aymen I.

“…IκB kinase subunit epsilon (IKKε), a key component of NFκB and interferon signalling, has been identified as a breast cancer oncogene. Here we report that the…”
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