The anthelmintic effect of aqueous methanol extract of Combretum molle (R. Br. x. G. Don) (Combretaceae) in lambs experimentally infected with Haemonchus contortus

The anthelmintic effect of aqueous methanol extract of Combretum molle (R. Br. x. G. Don) (Combretaceae) in lambs experimentally infected with Haemonchus contortus

The aqueous methanol extract from the stem-bark of Combretum molle was evaluated for anthelmintic activity in lambs infected with Haemonchus contortus using faecal egg count (FEC) reduction assay. The extract showed a dose-dependent reduction in FEC in infected animals. At doses of 500, 1000 and 200...

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Bibliographic Details
Published in:Veterinary parasitology Vol. 187; no. 1-2; pp. 280 - 284
Main Authors: Simon, M.K., Ajanusi, O.J., Abubakar, M.S., Idris, A.L., Suleiman, M.M.
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 08-06-2012
Subjects:
albendazole
Animals
Anthelmintic activity
Anthelmintics - administration & dosage
Anthelmintics - chemistry
Anthelmintics - therapeutic use
Combretum
Combretum - chemistry
Combretum molle
Dose-Response Relationship, Drug
Extraction
fecal egg count
Female
fruits
Haemonchiasis - drug therapy
Haemonchiasis - veterinary
Haemonchus - classification
Haemonchus contortus
lambs
leaves
Male
Medicinal plants
methanol
Methanol - chemistry
Plant Bark - chemistry
plant extracts
Plant Extracts - administration & dosage
Plant Extracts - chemistry
Plant Extracts - therapeutic use
Plant Stems - chemistry
Sheep
Sheep Diseases - drug therapy
Sheep Diseases - parasitology
veterinary parasitology
Medicinal plants
Haemonchus contortus
Extraction
Combretum molle
Anthelmintic activity
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Summary:The aqueous methanol extract from the stem-bark of Combretum molle was evaluated for anthelmintic activity in lambs infected with Haemonchus contortus using faecal egg count (FEC) reduction assay. The extract showed a dose-dependent reduction in FEC in infected animals. At doses of 500, 1000 and 2000mgkg–1, the extract caused FEC reduction of 63%, 69.25% and 96.23%, respectively. Similarly, the standard anthelmintic (albendazole) at a dose of 200mgkg–1 produced FEC reduction of 99.24%. FEC reduction produced by the extract at doses of 500 and 1000mgkg–1 is below the minimum standard of 90% FEC recommended by the World Association for the Advancement of Veterinary Parasitology (WAAVP). However, there was no significant (P>0.05) difference between the means of groups treated with 1000mgkg–1 and 2000mgkg–1 compared to that of albendazole. In this study, C. molle has shown a promising anthelmintic activity against experimental haemonchosis. Nonetheless, further studies to evaluate its detailed toxicity are required for the plant extract to be developed into a useful anthelmintic drug. There is also the need to evaluate other parts of the plant (root, leaves, fruits, etc.) for the same effect.
Bibliography:http://dx.doi.org/10.1016/j.vetpar.2011.12.022
ISSN:0304-4017
1873-2550
DOI:10.1016/j.vetpar.2011.12.022