Search Results - "Idiris, Alimjan"

Engineering of protein secretion in yeast: strategies and impact on protein production by Idiris, Alimjan, Tohda, Hideki, Kumagai, Hiromichi, Takegawa, Kaoru

“…Yeasts combine the ease of genetic manipulation and fermentation of a microorganism with the capability to secrete and modify foreign proteins according to a…”
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Collective cancer cell invasion in contact with fibroblasts through integrin‐α5β1/fibronectin interaction in collagen matrix by Miyazaki, Kaoru, Togo, Shinsaku, Okamoto, Reiko, Idiris, Alimjan, Kumagai, Hiromichi, Miyagi, Yohei

“…Interaction of cancer cells with cancer‐associated fibroblasts (CAFs) plays critical roles in tumor progression. Recently we proposed a new tumor invasion…”
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Microfabric Vessels for Embryoid Body Formation and Rapid Differentiation of Pluripotent Stem Cells by Sato, Hiroki, Idiris, Alimjan, Miwa, Tatsuaki, Kumagai, Hiromichi

“…Various scalable three-dimensional culture systems for regenerative medicine using human induced pluripotent stem cells (hiPSCs) have been developed to date…”
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A novel cardiac differentiation method of a large number and uniformly-sized spheroids using microfabricated culture vessels by Miwa, Tatsuaki, Idiris, Alimjan, Kumagai, Hiromichi

“…Cardiomyocytes differentiated from human induced pluripotent stem cells (hiPSCs) have great potential for regenerative medicine and drug discovery. In this…”
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High-throughput 3D Spheroid Formation and Effective Cardiomyocyte Differentiation from Human iPS Cells Using the Microfabric Vessels EZSPHERETM by Miwa, Tatsuaki, Idiris, Alimjan, Kumagai, Hiromichi

“…High-throughput 3D spheroid formation from human induced pluripotent stem cells (hiPSCs) can be easily performed using the unique microfabric vessels EZSPHERE,…”
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Generation of GM-CSF-producing antigen-presenting cells that induce a cytotoxic T cell-mediated antitumor response by Mashima, Hiroaki, Zhang, Rong, Kobayashi, Tsuyoshi, Hagiya, Yuichiro, Tsukamoto, Hirotake, Liu, Tianyi, Iwama, Tatsuaki, Yamamoto, Masateru, Lin, Chiahsuan, Nakatsuka, Ryusuke, Mishima, Yuta, Watanabe, Noriko, Yamada, Takashi, Senju, Satoru, Kaneko, Shin, Idiris, Alimjan, Nakatsura, Tetsuya, Ohdan, Hideki, Uemura, Yasushi

“…Immunotherapy using dendritic cells (DCs) is a promising treatment modality for cancer. However, the limited number of functional DCs from peripheral blood has…”
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Improved safety of induced pluripotent stem cell-derived antigen-presenting cell-based cancer immunotherapy by Mashima, Hiroaki, Zhang, Rong, Kobayashi, Tsuyoshi, Tsukamoto, Hirotake, Liu, Tianyi, Iwama, Tatsuaki, Hagiya, Yuichiro, Yamamoto, Masateru, Fukushima, Satoshi, Okada, Seiji, Idiris, Alimjan, Kaneko, Shin, Nakatsura, Tetsuya, Ohdan, Hideki, Uemura, Yasushi

“…The tumorigenicity and toxicity of induced pluripotent stem cells (iPSCs) and their derivatives are major safety concerns in their clinical application…”
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Enhanced protein secretion from multiprotease-deficient fission yeast by modification of its vacuolar protein sorting pathway by Idiris, Alimjan, Tohda, Hideki, Sasaki, Mayumi, Okada, Katsunori, Kumagai, Hiromichi, Giga-Hama, Yuko, Takegawa, Kaoru

“…Previously, we achieved approximately 30-fold enhanced secretion of the protease-sensitive model protein human growth hormone (hGH) by multiple gene deletion…”
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Processing and maturation of carboxypeptidase Y and alkaline phosphatase in Schizosaccharomyces pombe by Mukaiyama, Hiroyuki, Iwaki, Tomoko, Idiris, Alimjan, Takegawa, Kaoru

“…Schizosaccharomyces pombe carboxypeptidase Y (CPY) is synthesized as a zymogen and transported into the vacuole where maturation and activation occurs. The…”
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Development of iPS cell culture platform for regenerative medicine by Kumagai, Hiromichi, Idiris, Alimjan

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Enhanced productivity of protease-sensitive heterologous proteins by disruption of multiple protease genes in the fission yeast Schizosaccharomyces pombe by Idiris, Alimjan, Tohda, Hideki, Bi, Ke-wei, Isoai, Atsushi, Kumagai, Hiromichi, Giga-Hama, Yuko

“…The creation of protease-deficient mutants to avoid product degradation is one of the current strategies employed to improve productivity and secretion…”
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Production of heterologous proteins using the fission-yeast (Schizosaccharomyces pombe) expression system by Takegawa, Kaoru, Tohda, Hideki, Sasaki, Mayumi, Idiris, Alimjan, Ohashi, Takao, Mukaiyama, Hiroyuki, Giga-Hama, Yuko, Kumagai, Hiromichi

“…The fission yeast Schizosaccharomyces pombe is a particularly useful model for studying the function and regulation of genes from higher eukaryotes. The genome…”
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Construction of a protease‐deficient strain set for the fission yeast Schizosaccharomyces pombe, useful for effective production of protease‐sensitive heterologous proteins by Idiris, Alimjan, Bi, Kewei, Tohda, Hideki, Kumagai, Hiromichi, Giga‐Hama, Yuko

“…One of the major problems hindering effective production and purification of heterologous proteins from the fission yeast Schizosaccharomyces pombe is…”
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gap-filling sequence on the left arm of chromosome 2 in fission yeast Schizosaccharomyces pombe by Sasaki, Mayumi, Idiris, Alimjan, Tada, Aya, Kumagai, Hiromichi, Giga-Hama, Yuko, Tohda, Hideki

“…We report a gap-filling sequence between SPBPB21E7.09 (in contig c1348) and SPBPB10D8.01 (in contig pB10D8) on the left arm of chromosome 2 in the fission…”
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High-throughput 3D Spheroid Formation and Effective Cardiomyocyte Differentiation from Human iPS Cells Using the Microfabric Vessels EZSPHERE TM by Miwa, Tatsuaki, Idiris, Alimjan, Kumagai, Hiromichi

“…High-throughput 3D spheroid formation from human induced pluripotent stem cells (hiPSCs) can be easily performed using the unique microfabric vessels EZSPHERE,…”
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Spring mechanics of α-helical polypeptide by Idiris, Alimjan, Alam, Mohammad Taufiq, Ikai, Atsushi

“…To design protein- and polymer-based micro-machineries, it is important to understand the mechanical properties of basic structural elements such as the…”
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Force Measurement for Antigen−Antibody Interaction by Atomic Force Microscopy Using a Photograft-Polymer Spacer by Idiris, Alimjan, Kidoaki, Satoru, Usui, Kengo, Maki, Tei, Suzuki, Harukazu, Ito, Masayoshi, Aoki, Makoto, Hayashizaki, Yoshihide, Matsuda, Takehisa

“…To determine the intermolecular force on protein−protein interaction (PPI) by atomic force microscopy (AFM), a photograft-polymer spacer for protein molecules…”
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Spring mechanics of [alpha]-helical polypeptide by Idiris, Alimjan, Mohammad Taufiq Alam, Ikai, Atsushi

“…To design protein- and polymer-based micro-machineries, it is important to understand the mechanical properties of basic structural elements such as the…”
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Intra- and intermolecular mechanics of proteins and polypeptides studied by AFM: with applications by Ikai, Atsushi, Idiris, Alimjan, Sekiguchi, Hiroshi, Arakawa, Hideo, Nishida, Shuhei

“…In order to use an atomic force microscope to measure the intramolecular mechanics of a single protein or polymer molecule, the very initial stage of…”
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Molecular cloning and structural characterization of the hagfish proteinase inhibitor of the alpha-2-macroglobulin family by Idiris, Alimjan, Ohtsubo, Ken-ichi, Yoza, Koh-ichi, Osada, Toshiya, Nakamichi, Noboru, Matsumura, Toshiharu, Ikai, Atsushi

“…The "most primitive" living vertebrate the hagfish has a dimeric proteinase inhibitor, a protein homologous to human alpha2-macroglobulin, in its plasma at…”
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