Search Results - "Idel, Christian"

Editorial for the Special Issue "Squamous Cell Cancer of the Head and Neck-Time to Arrive in the 21st Century of Oncology" by Perner, Sven, Idel, Christian

“…Squamous cell carcinoma of the head and neck (HNSCC) is the sixth most common cancer worldwide [...]…”
Get full text

Recurrent HNSCC Harbor an Immunosuppressive Tumor Immune Microenvironment Suggesting Successful Tumor Immune Evasion by Watermann, Christian, Pasternack, Helen, Idel, Christian, Ribbat-Idel, Julika, Brägelmann, Johannes, Kuppler, Patrick, Offermann, Anne, Jonigk, Danny, Kühnel, Mark Philipp, Schröck, Andreas, Dreyer, Eva, Rosero, Christian, Nathansen, Jacqueline, Dubrovska, Anna, Tharun, Lars, Kirfel, Jutta, Wollenberg, Barbara, Perner, Sven, Krupar, Rosemarie

“…Recurrent tumors (RT) of head and neck squamous cell carcinoma (HNSCC) occur in up to 60%, with poor therapeutic response and detrimental prognosis. We…”
Get full text

Elevated LSD1 and SNAIL Expression Indicate Poor Prognosis in Hypopharynx Carcinoma by Bottner, Justus, Ribbat-Idel, Julika, Klapper, Luise, Jagomast, Tobias, Lemster, Anna-Lena, Perner, Sven, Idel, Christian, Kirfel, Jutta

“…Head and neck squamous cell carcinomas (HNSCC) are among the most common cancers worldwide and are associated with a poor prognosis for patients. Among HNSCC,…”
Get full text

Tirofiban potentiates agonist-induced platelet activation and degranulation, despite effectively inhibiting aggregation by Aguiar Bucsai, Martina, Idel, Christian, Wollenberg, Barbara, Mannhalter, Christine, Verschoor, Admar

“…We aimed to investigate the effects of integrin αIIbβ3 inhibitor tirofiban on hallmarks of platelet activation, degranulation, and aggregation during its use…”
Get full text

Type 2-like polarization and elevated CXCL4 secretion of monocyte derived macrophages upon internalization of plasma-derived exosomes from head and neck cancer patients by Theodoraki, Marie-Nicole, Huber, Diana, Hofmann, Linda, Werner, Lotte, Idel, Christian, Fleckner, Jonas, Plötze-Martin, Kirstin, Schütt, Lutz, Brunner, Cornelia, Depping, Reinhard, Hoffmann, Thomas K, Bruchhage, Karl-Ludwig, Pries, Ralph

“…Exosomes are closely associated with different aspects of tumor-progression in patients with head and neck squamous cell carcinoma (HNSCC), such as…”
Get full text

TRIM21 Expression as a Prognostic Biomarker for Progression-Free Survival in HNSCC by von Bernuth, Amelie, Ribbat-Idel, Julika, Klapper, Luise, Jagomast, Tobias, Rades, Dirk, Leichtle, Anke, Pries, Ralph, Bruchhage, Karl-Ludwig, Perner, Sven, Offermann, Anne, Sailer, Verena, Idel, Christian

“…Patients with head and neck squamous cell carcinoma (HNSCC) continue to have a rather poor prognosis. Treatment-related comorbidities have negative impacts on…”
Get full text

Partial recovery of peripheral blood monocyte subsets in head and neck squamous cell carcinoma patients upon radio(chemo)therapy is associated with decreased plasma CXCL11 by Idel, Christian, Fleckner, Jonas, Plötze-Martin, Kirstin, Werner, Lotte, Rades, Dirk, Theodoraki, Marie-Nicole, Hofmann, Linda, Huber, Diana, Leichtle, Anke, Hoffmann, Thomas K, Bruchhage, Karl-Ludwig, Pries, Ralph

“…Head and neck squamous cell carcinoma (HNSCC) represents a common and heterogeneous malignancy of the oral cavity, pharynx and larynx. Surgery and…”
Get full text

EVI1 as a Marker for Lymph Node Metastasis in HNSCC by Idel, Christian, Ribbat-Idel, Julika, Kuppler, Patrick, Krupar, Rosemarie, Offermann, Anne, Vogel, Wenzel, Rades, Dirk, Kirfel, Jutta, Wollenberg, Barbara, Perner, Sven

“…HNSCC is the sixth most common cancer in humans and has still a very poor prognosis. The treatment methods so far are very often associated with mutilation and…”
Get full text

NR2F6 as a Prognostic Biomarker in HNSCC by Klapper, Luise, Ribbat-Idel, Julika, Kuppler, Patrick, Paulsen, Finn-Ole, Bruchhage, Karl-Ludwig, Rades, Dirk, Offermann, Anne, Kirfel, Jutta, Wollenberg, Barbara, Idel, Christian, Perner, Sven

“…Head and neck squamous cell carcinoma (HNSCC)is the 6th most common cancer in humans worldwide and is associated with a poor prognosis for patients. NR2F6 has…”
Get full text

Immunometabolic Determinants of Chemoradiotherapy Response and Survival in Head and Neck Squamous Cell Carcinoma by Krupar, Rosemarie, Hautmann, Matthias G., Pathak, Ravi R., Varier, Indu, McLaren, Cassandra, Gaag, Doris, Hellerbrand, Claus, Evert, Matthias, Laban, Simon, Idel, Christian, Sandulache, Vlad, Perner, Sven, Bosserhoff, Anja K., Sikora, Andrew G.

“…Tumor immune microenvironment and tumor metabolism are major determinants of chemoradiotherapy response. The interdependency and prognostic significance of…”
Get full text

Cooperation of genes in HPV16 E6/E7-dependent cervicovaginal carcinogenesis trackable by endoscopy and independent of exogenous estrogens or carcinogens by Böttinger, Paula, Schreiber, Karin, Hyjek, Elizabeth, Krausz, Thomas, Spiotto, Michael T, Steiner, Madeline, Idel, Christian, Booras, Heather, Beck-Engeser, Gabriele, Riederer, Jessie, Willimsky, Gerald, Wolf, Steven P, Karrison, Theodore, Jensen, Elizabeth, Weichselbaum, Ralph R, Nakamura, Yusuke, Yew, Poh Yin, Lambert, Paul F, Kurita, Takeshi, Kiyotani, Kazuma, Leisegang, Matthias, Schreiber, Hans

“…Abstract Human papillomavirus (HPV) infection is necessary but insufficient for progression of epithelial cells from dysplasia to carcinoma-in situ (CIS) to…”
Get full text

CDK19 as a Potential HPV-Independent Biomarker for Recurrent Disease in HNSCC by Paulsen, Finn-Ole, Idel, Christian, Ribbat-Idel, Julika, Kuppler, Patrick, Klapper, Luise, Rades, Dirk, Bruchhage, Karl-Ludwig, Wollenberg, Barbara, Brägelmann, Johannes, Perner, Sven, Offermann, Anne

“…The Mediator complex is a central integrator of transcription and a hub for the regulation of gene expression. Cyclin dependent kinase (CDK) 19 and its paralog…”
Get full text

Radiotherapy related skin toxicity (RAREST-01): Mepitel® film versus standard care in patients with locally advanced head-and-neck cancer by Narvaez, Carlos, Doemer, Claudia, Idel, Christian, Setter, Cornelia, Olbrich, Denise, Ujmajuridze, Zaza, Carl, Jesper Hansen, Rades, Dirk

“…The aim of the present trial is to investigate a new option of skin protection in order to reduce the rate of grade ≥ 2 skin toxicity in patients receiving…”
Get full text

Spatial Distribution of Immune Cells in Head and Neck Squamous Cell Carcinomas by Idel, Christian, Ribbat-Idel, Julika, Klapper, Luise, Krupar, Rosemarie, Bruchhage, Karl-Ludwig, Dreyer, Eva, Rades, Dirk, Polasky, Christina, Offermann, Anne, Kirfel, Jutta, Perner, Sven, Wollenberg, Barbara

“…Head and neck squamous cell carcinomas (HNSCCs) have a very moderate response rate to immune checkpoint inhibitor (ICI) treatment compared to other cancer…”
Get full text

Immunologic "Cold" Squamous Cell Carcinomas of the Head and Neck Are Associated With an Unfavorable Prognosis by Ribbat-Idel, Julika, Perner, Sven, Kuppler, Patrick, Klapper, Luise, Krupar, Rosemarie, Watermann, Christian, Paulsen, Finn-Ole, Offermann, Anne, Bruchhage, Karl-Ludwig, Wollenberg, Barbara, Idel, Christian

“…Head and neck squamous cell carcinoma (HNSCC) represents a common cancer worldwide. Past therapeutic advances have not significantly improved HNSCC prognosis…”
Get full text

Smoking-, Alcohol-, and Age-Related Alterations of Blood Monocyte Subsets and Circulating CD4/CD8 T Cells in Head and Neck Cancer by Idel, Christian, Loyal, Kristin, Rades, Dirk, Hakim, Samer G, Schumacher, Udo, Bruchhage, Karl-Ludwig, Pries, Ralph

“…Head and neck squamous cell carcinoma (HNSCC) represents a heterogeneous malignant disease of the oral cavity, pharynx, and larynx. Although cigarette smoking,…”
Get full text

Demographics and access to head and neck cancer care in rural areas compared to urban areas in Germany by Vahl, Julius M., Nagel, Gabriele, Grages, Ayla, Brand, Matthias, Witzleben, Adrian, Sonntag, Michael, Theodoraki, Marie‐Nicole, Greve, Jens, Aboukors, Tsima, Denkinger, Michael, Dallmeier, Dhayana, Idel, Christian, Hoffmann, Thomas K., Laban, Simon

“…Background Demographic development in rural and urban areas differs substantially. Demographics and access to specialized head and neck cancer centers may…”
Get full text

Regional outcome disparities in German head and neck cancer patients: Shorter survival in Eastern Germany by Vahl, Julius M., Nagel, Gabriele, Abou Kors, Tsima, Brand, Matthias, Witzleben, Adrian, Sonntag, Michael, Grages, Ayla, Theodoraki, Marie N., Greve, Jens, Denkinger, Michael, Dallmeier, Dhayana, Idel, Christian, Stilgenbauer, Stephan, Hoffmann, Thomas K., Laban, Simon

“…Introduction Demographics are important prognostic factors in malignant diseases. A nationwide analysis concerning the prognostic impact of demographics in…”
Get full text

Increased Abundances of CD16+ Non-Classical Monocytes Accompany with Elevated Monocytic PD-L1 and CD4+ T Cell Disturbances in Oropharyngeal Cancer by Idel, Christian, Polasky, Christina, Ribbat-Idel, Julika, Loyal, Kristin, Perner, Sven, Rades, Dirk, Bruchhage, Karl-Ludwig, Pries, Ralph

“…Background: Patients with human papilloma virus (HPV)-related oropharyngeal cancer have a better prognosis than nonvirally associated patients, most likely…”
Get full text

Performance of Different Diagnostic PD-L1 Clones in Head and Neck Squamous Cell Carcinoma by Ribbat-Idel, Julika, Dressler, Franz F, Krupar, Rosemarie, Watermann, Christian, Paulsen, Finn-Ole, Kuppler, Patrick, Klapper, Luise, Offermann, Anne, Wollenberg, Barbara, Rades, Dirk, Laban, Simon, Reischl, Markus, Bruchhage, Karl-Ludwig, Idel, Christian, Perner, Sven

“…The approval of immune checkpoint inhibitors in combination with specific diagnostic biomarkers presents new challenges to pathologists as tumor tissue needs…”
Get full text