Search Results - "Ide, Lucienne"

Hematopoietic stem-cell gene therapy of hemophilia A incorporating a porcine factor VIII transgene and nonmyeloablative conditioning regimens by Ide, Lucienne M., Gangadharan, Bagirath, Chiang, Kuang-Yueh, Doering, Christopher B., Spencer, H. Trent

“…Insufficient expression of factor VIII (fVIII) is a major hurdle in the development of successful nucleic acid treatments for hemophilia. However, we recently…”
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High-level expression of porcine factor VIII from genetically modified bone marrow–derived stem cells by Gangadharan, Bagirath, Parker, Ernest T., Ide, Lucienne M., Spencer, H. Trent, Doering, Christopher B.

“…Clinical success for gene therapy of hemophilia A will be judged by achievement of sustained, therapeutic levels of coagulation factor VIII (fVIII). Previous…”
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Functional aspects of factor VIII expression after transplantation of genetically-modified hematopoietic stem cells for hemophilia A by Ide, Lucienne M., Iwakoshi, Neal N., Gangadharan, Bagirath, Jobe, Shawn, Moot, Robert, McCarty, David, Doering, Christopher B., Spencer, H. Trent

“…Background Major complications with respect to the development of gene therapy treatments for hemophilia A include low factor VIII (fVIII) expression and…”
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Actin Cytoskeleton Organization and Posttranscriptional Regulation of Endothelial Nitric Oxide Synthase During Cell Growth by Searles, Charles D, Ide, Lucienne, Davis, Michael E, Cai, Hua, Weber, Martina

“…Posttranscriptional regulation of endothelial nitric oxide synthase (eNOS) expression is an important mechanism by which endothelial cells respond to various…”
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Transduction of murine hematopoietic stem cells and in vivo selection of gene-modified cells by Ide, Lucienne M, Javazon, Elisabeth, Spencer, H Trent

“…Hematopoietic stem cells (HSCs) were among the first targets of genetic manipulation for the purpose of treating human diseases. The translational aspects of…”
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FVIII Tolerance Following Nonmyeloablative Transplantation of Hematopoietic Stem Cells Engineered To Encode a High-Expression Factor VIII Transgene in Hemophilia A Mice by Ide, Lucienne M., Gangadharan, Bagirath, Doering, Christopher, Spencer, H. Trent

“…Clinical gene therapy trials for hemophilia A have failed due to insufficient target cell transduction or expression of factor VIII (fVIII). Animal studies…”
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Distributing healthcare through tech: The next wave of innovation by Ide, Lucienne Marie

“…[...]the potential is greater than simply monitoring patients who may need consistent care for chronic conditions, or who are hesitant to venture out and…”
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Post-Transplantation Immunosuppression Facilitates Sustained Expression of Porcine Factor VIII after Reduced-Intensity Transplantation of Genetically-Modified Stem Cells by Ide, Lucienne M., Gangadharan, Bagirath, Chiang, K.Y., Doering, Christopher, Spencer, H. Trent

“…A major barrier to successful gene therapy for hemophilia A using bone marrow cells is achieving engraftment of a sufficient number of gene-modified cells to…”
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Transplantation of hematopoietic stem cells encoding a high-expression factor VIII transgene under myeloablative and nonmyeloablative conditioning provides curative factor VIII activity to hemophilia A mice by Doering, Christopher B., Ide, Lucienne M., Gangadharan, Bagirath, McCarty, David, Javazon, Elisabeth, Spencer, H. Trent

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High-level expression of porcine factor VIII from genetically modified bone marrow-derived stem cells. Commentary by PONDER, Katherine P, GANGADHARAN, Bagirath, PARKER, Ernest T, IDE, Lucienne M, TRENT SPENCER, H, DOENNG, Christopher B

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912. Strategies Using Retroviral Coexpression of Indoleamine 2,3 Dioxygenase and Fas Ligand for Allogeneic Bone Marrow Transplantation by Gangadharan, Bagirath, Ide, Lucienne, Holtzclaw, David, Archer, David, Spencer, H Trent

“…Regulation of allogenic immune response could play a very significant role in establishing stable mixed chimerism for the treatment of several hematological…”
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Hematopoietic stem cell mediated gene therapy for hemophilia A using high-expression factor VIII constructs by Ide, Lucienne Marie

“…Clinical gene therapy trials for hemophilia A to date have failed due to insufficient target cell transduction or expression of coagulation factor VIII…”
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Hematopoietic stem cell mediated gene therapy for hemophilia A using high-expression factor VIII constructs by Ide, Lucienne Marie

“…Clinical gene therapy trials for hemophilia A to date have failed due to insufficient target cell transduction or expression of coagulation factor VIII…”
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Distributing healthcare through tech: The next wave of innovation: Medical profession must explore every option to battle COVID-19 pandemic by Ide, Lucienne Marie

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