Search Results - "Idbaih, A."

Glioblastoma targeted therapy: updated approaches from recent biological insights by Touat, M., Idbaih, A., Sanson, M., Ligon, K.L.

“…Glioblastoma (WHO grade IV astrocytoma) is the most frequent primary brain tumor in adults, representing a highly heterogeneous group of neoplasms that are…”
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Structural and functional intratumor heterogeneities in glioblastoma: a spacetime odyssey at single-cell level by Idbaih, A.

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TERT promoter mutations in gliomas, genetic associations and clinico-pathological correlations by Labussière, M, Di Stefano, A L, Gleize, V, Boisselier, B, Giry, M, Mangesius, S, Bruno, A, Paterra, R, Marie, Y, Rahimian, A, Finocchiaro, G, Houlston, R S, Hoang-Xuan, K, Idbaih, A, Delattre, J-Y, Mokhtari, K, Sanson, M

“…Background: The role of telomerase reverse transcriptase ( TERT ) in gliomagenesis has been recently further strengthened by the frequent occurrence of TERT…”
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IDH1 or IDH2 mutations predict longer survival and response to temozolomide in low-grade gliomas by HOUILLIER, C, WANG, X, HOANG-XUAN, K, SANSON, M, DELATTRE, J.-Y, KALOSHI, G, MOKHTARI, K, GUILLEVIN, R, LAFFAIRE, J, PARIS, S, BOISSELIER, B, IDBAIH, A, LAIGLE-DONADEY, F

“…Recent studies have shown that IDH1 and IDH2 mutations occur frequently in gliomas, including low-grade gliomas. However, their impact on the prognosis and…”
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Overcoming the blood brain barrier in glioblastoma: Status and future perspective by Ahmed, M.H., Canney, M., Carpentier, A., Idbaih, A.

“…Glioblastoma is the most common primary brain malignancy in adults. Treatment of glioblastoma patients is based on neurosurgery, radiation therapy and…”
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Identification, validation and biological characterisation of novel glioblastoma tumour microenvironment subtypes: implications for precision immunotherapy by White, K., Connor, K., Meylan, M., Bougoüin, A., Salvucci, M., Bielle, F., O’Farrell, A.C., Sweeney, K., Weng, L., Bergers, G., Dicker, P., Ashley, D.M., Lipp, E.S., Low, J.T., Zhao, J., Wen, P., Prins, R., Verreault, M., Idbaih, A., Biswas, A., Prehn, J.H.M., Lambrechts, D., Arijs, I., Lodi, F., Dilcan, G., Lamfers, M., Leenstra, S., Fabro, F., Ntafoulis, I., Kros, J.M., Cryan, J., Brett, F., Quissac, E., Beausang, A., MacNally, S., O’Halloran, P., Clerkin, J., Bacon, O., Kremer, A., Chi Yen, R.T., Varn, F.S., Verhaak, R.G.W., Sautès-Fridman, C., Fridman, W.H., Byrne, A.T.

“…New precision medicine therapies are urgently required for glioblastoma (GBM). However, to date, efforts to subtype patients based on molecular profiles have…”
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New hints towards a precision medicine strategy for IDH wild-type glioblastoma by White, K., Connor, K., Clerkin, J., Murphy, B.M., Salvucci, M., O'Farrell, A.C., Rehm, M., O'Brien, D., Prehn, J.H.M., Niclou, S.P., Lamfers, M.L.M., Verreault, M., Idbaih, A., Verhaak, R., Golebiewska, A., Byrne, A.T.

“…Glioblastoma represents the most common primary malignancy of the central nervous system in adults and remains a largely incurable disease. The elucidation of…”
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A new alternative mechanism in glioblastoma vascularization: tubular vasculogenic mimicry by El Hallani, Soufiane, Boisselier, Blandine, Peglion, Florent, Rousseau, Audrey, Colin, Carole, Idbaih, Ahmed, Marie, Yannick, Mokhtari, Karima, Thomas, Jean-Léon, Eichmann, Anne, Delattre, Jean-Yves, Maniotis, Andrew J., Sanson, Marc

“…Glioblastoma is one of the most angiogenic human tumours and endothelial proliferation is a hallmark of the disease. A better understanding of glioblastoma…”
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All the 1p19q codeleted gliomas are mutated on IDH1 or IDH2 by LABUSSIERE, M, IDBAIH, A, DUCRAY, F, EL HALLANI, S, MOKHTARI, K, HOANG-XUAN, K, DELATTRE, J.-Y, SANSON, M, WANG, X.-W, MARIE, Y, BOISSELIER, B, FALET, C, PARIS, S, LAFFAIRE, J, CARPENTIER, C, CRINIERE, E

“…Recently, the gene encoding the human cytosolic NADPH-dependent isocitrate dehydrogenase (IDH1) was reported frequently mutated in gliomas. Rare mutations were…”
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Prognosis of glioblastoma patients improves significantly over time interrogating historical controls by Thomas-Joulié, A., Tran, S., El Houari, L., Seyve, A., Bielle, F., Birzu, C., Lozano-Sanchez, F., Mokhtari, K., Giry, M., Marie, Y., Laigle-Donadey, F., Dehais, C., Houillier, C., Psimaras, D., Alentorn, A., Laurenge, A., Touat, M., Sanson, M., Hoang-Xuan, K., Kas, A., Rozenblum, L., Habert, M.-O., Nichelli, L., Leclercq, D., Galanaud, D., Jacob, J., Karachi, C., Capelle, L., Carpentier, A., Mathon, B., Belin, L., Idbaih, A.

“…Glioblastoma (GBM) is the most common devastating primary brain cancer in adults. In our clinical practice, median overall survival (mOS) of GBM patients seems…”
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Leptomeningeal tumor response to combined MAPK/ERK inhibition in V600E-mutated gliomas despite undetectable CSF drug levels by Hottinger, A.F., Bensaid, D., De Micheli, R., Moura, B., Mokhtari, K., Cardoso, E., Idbaih, A., Stupp, R.

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BRAF mutation in overlapping form of Erdheim-Chester and Rosai Dorfman diseases: a unique case restricted to the central nervous system by Dufour, J., Mathon, B., Touat, M., Hoang-Xuan, K., Mokhtari, K., Idbaih, A.

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Glioma tumor grade correlates with parkin depletion in mutant p53-linked tumors and results from loss of function of p53 transcriptional activity by Viotti, J, Duplan, E, Caillava, C, Condat, J, Goiran, T, Giordano, C, Marie, Y, Idbaih, A, Delattre, J-Y, Honnorat, J, Checler, F, Alves da Costa, C

“…Gliomas represent the most frequent form of primary brain tumors in adults, the prognosis of which remains extremely poor. Inactivating mutations on the tumor…”
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Temozolomide for low-grade gliomas: Predictive impact of 1p/19q loss on response and outcome by KALOSHI, G, BENOUAICH-AMIEL, A, CAPELLE, L, DUFFAU, H, CORNU, P, SIMON, J.-M, MOKHTARI, K, POLIVKA, M, OMURO, A, CARPENTIER, A, SANSON, M, DELATTRE, J.-Y, DIAKITE, F, HOANG-XUAN, K, TAILLIBERT, S, LEJEUNE, J, LAIGLE-DONADEY, F, RENARD, M.-A, IRAQI, W, IDBAIH, A, PARIS, S

“…To evaluate the predictive impact of chromosome 1p/19q deletions on the response and outcome of progressive low-grade gliomas (LGG) treated with up-front…”
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OMICS and biomarkers of glial tumors by Idbaih, A

“…OMICS is the term used to designate new biological sciences investigating a large group of molecules in biological samples. For instance, genomics and…”
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Whole brain radiotherapy with concurrent temozolomide in multifocal and/or multicentric newly diagnosed glioblastoma by Lahmi, L., Idbaih, A., Rivin Del Campo, E., Hoang-Xuan, K., Mokhtari, K., Sanson, M., Canova, CH, Carpentier, A., Jacob, J., Maingon, P., Feuvret, L.

“…•Administering concurrent TMZ and WBRT to patients with M/M GBM is feasible.•Median OS and PFS were 10 months [4–25] and 5 months [3–21], respectively.•Most…”
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Low penetrance susceptibility to glioma is caused by the TP53 variant rs78378222 by Enciso-Mora, V, Hosking, F J, Di Stefano, A L, Zelenika, D, Shete, S, Broderick, P, Idbaih, A, Delattre, J-Y, Hoang-Xuan, K, Marie, Y, Labussière, M, Alentorn, A, Ciccarino, P, Rossetto, M, Armstrong, G, Liu, Y, Gousias, K, Schramm, J, Lau, C, Hepworth, S J, Schoemaker, M, Strauch, K, Müller-Nurasyid, M, Schreiber, S, Franke, A, Moebus, S, Eisele, L, Swerdlow, A, Simon, M, Bondy, M, Lathrop, M, Sanson, M, Houlston, R S

“…Background: Most of the heritable risk of glioma is presently unaccounted for by mutations in known genes. In addition to rare inactivating germline mutations…”
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Long-term impact of temozolomide on 1p/19q-codeleted low-grade glioma growth kinetics by Izquierdo, C., Alentorn, A., Idbaih, A., Simó, M., Kaloshi, G., Ricard, D., Barritault, M., Meyronet, D., Bruna, J., Honnorat, J., Delattre, J. Y., Ducray, F.

“…Although upfront temozolomide (TMZ) has been widely-used to treat 1p/19q-codeleted diffuse low-grade gliomas (LGG), its long-term impact on the growth kinetics…”
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European Reference Network for rare adult solid cancers, statement and integration to health care systems of member states: a position paper of the ERN EURACAN by Blay, J.-Y., Casali, P., Bouvier, C., Dehais, C., Galloway, I., Gietema, J., Halámková, J., Hindi, N., Idbaih, A., Kinloch, E., Klümpen, H.-J., Kolarova, T., Kopeckova, K., Lovey, J., Magalhaes, M., Oselin, K., Piperno-Neumann, S., Ravnsbaek, A., Rogasik, M., Safwat, A., Scheipl, S., Seckl, M., Taylor, J., Temnyk, M., Trama, A., Urbonas, M., Wartenberg, M., Weinman, A.

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MRI features of neurodegenerative Langerhans cell histiocytosis by Martin-Duverneuil, N, Idbaih, A, Hoang-Xuan, K, Donadieu, J, Genereau, T, Guillevin, R, Chiras, J

“…CNS complications of LCH include "space occupying" lesions corresponding to histiocytic granulomas and "neurodegenerative" presentation (ND-LCH) characterized…”
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