Search Results - "Ichtchenko, K."

Binding of Neuroligins to PSD-95 by Irie, M., Hata, Y., Takeuchi, M., Ichtchenko, K., Toyoda, A., Hirao, K., Takai, Y., Rosahl, T. W., Södhof, T. C.

“…PSD-95 is a component of postsynaptic densities in central synapses. It contains three PDZ domains that localize N-methyl-D-aspartate receptor subunit 2 (NMDA2…”
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Conserved domain structure of beta-neurexins. Unusual cleaved signal sequences in receptor-like neuronal cell-surface proteins by USHKARYOV, YU. A, HATA, Y, ICHTCHENKO, K, MOOMAW, C, AFENDIS, S, SLAUGHTER, C. A, SÜDHOF, T. C

“…Neurexins, a family of neuronal cell-surface proteins, consist of the longer alpha-neurexins (I alpha, II alpha, and III alpha) and the shorter beta-neurexins…”
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A novel ubiquitously expressed alpha-latrotoxin receptor is a member of the CIRL family of G-protein-coupled receptors by Ichtchenko, K. (New York University Medical Center, New York, NY.), Bittner, M.A, Krasnoperov, V, Little, A.R, Chepurny, O, Holz, R.W, Petrenko, A.G

“…Poisoning with alpha-latrotoxin, a neurotoxic protein from black widow spider venom, results in a robust increase of spontaneous synaptic transmission and…”
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Structure of the LDL Receptor Extracellular Domain at Endosomal pH by Rudenko, Gabby, Henry, Lisa, Henderson, Keith, Ichtchenko, Konstantin, Brown, Michael S., Goldstein, Joseph L., Deisenhofer, Johann

“…The low-density lipoprotein receptor mediates cholesterol homeostasis through endocytosis of lipoproteins. It discharges its ligand in the endosome at pH < 6…”
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Neuroligin 1 Is a Postsynaptic Cell-Adhesion Molecule of Excitatory Synapses by Song, Ji-Ying, Ichtchenko, Konstantin, Sudhof, Thomas C., Brose, Nils

“…At the synapse, presynaptic membranes specialized for vesicular traffic are linked to postsynaptic membranes specialized for signal transduction. The…”
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Neuronal targeting, internalization and biological activity of a recombinant atoxic derivative of botulinum neurotoxin A by Vazquez-Cintron, E., Pellett, S., Tepp, W.H., Stanker, L.H., Band, P.A., Johnson, E.A., Ichtchenko, K.

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alpha-Latrotoxin receptor CIRL/latrophilin 1 (CL1) defines an unusual family of ubiquitous G-protein-linked receptors. G-protein coupling not required for triggering exocytosis by Sugita, S, Ichtchenko, K, Khvotchev, M, Südhof, T C

“…alpha-Latrotoxin, a potent excitatory neurotoxin, binds to two receptors: a G-protein-coupled receptor called CIRL/latrophilin 1 (CL1) and a cell-surface…”
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Neuroligin 1: A splice site-specific ligand for β-neurexins by Ichtchenko, Konstantin, Hata, Yutaka, Nguyen, Thai, Ullrich, Beate, Missler, Markus, Moomaw, Carolyn, Südhof, Thomas C

“…Neurexins are neuronal cell surface proteins with hundreds of isoforms generated by alternative splicing. Here we describe neuroligin 1, a neuronal cell…”
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Structures, Alternative Splicing, and Neurexin Binding of Multiple Neuroligins () by Ichtchenko, Konstantin, Nguyen, Thai, Südhof, Thomas C.

“…Neuroligin 1 is a neuronal cell surface protein that binds to a subset of neurexins, polymorphic cell surface proteins that are also localized on neurons…”
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The evolutionary pressure to inactivate. A subclass of synaptotagmins with an amino acid substitution that abolishes Ca2+ binding by von Poser, C, Ichtchenko, K, Shao, X, Rizo, J, Südhof, T C

“…Synaptotagmin I is a Ca2+-binding protein of synaptic vesicles that serves as a Ca2+ sensor for neurotransmitter release and was the first member found of a…”
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Protein-tyrosine Phosphatase-ς Is a Novel Member of the Functional Family of α-Latrotoxin Receptors by Krasnoperov, Valery, Bittner, Mary A., Mo, Wenjun, Buryanovsky, Leonid, Neubert, Thomas A., Holz, Ronald W., Ichtchenko, Konstantin, Petrenko, Alexander G.

“…Receptor-like protein-tyrosine phosphatase sigma (PTPς) is essential for neuronal development and function. Here we report that PTPς is a target of…”
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α-Latrotoxin action probed with recombinant toxin: receptors recruit α-latrotoxin but do not transduce an exocytotic signal by Ichtchenko, Konstantin, Khvotchev, Mikhail, Kiyatkin, Nikita, Simpson, Lance, Sugita, Shuzo, Südhof, Thomas C.

“…α‐Latrotoxin stimulates neurotransmitter release probably by binding to two receptors, CIRL/latrophilin 1 (CL1) and neurexin Iα. We have now produced…”
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Neurexin Iα Is a Major α-Latrotoxin Receptor That Cooperates in α-Latrotoxin Action by Geppert, Martin, Khvotchev, Mikhail, Krasnoperov, Valery, Goda, Yukiko, Missler, Markus, Hammer, Robert E., Ichtchenko, Konstantin, Petrenko, Alexander G., Südhof, Thomas C.

“…α-Latrotoxin is a potent neurotoxin from black widow spider venom that binds to presynaptic receptors and causes massive neurotransmitter release. A surprising…”
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Post-translational Proteolytic Processing of the Calcium-independent Receptor of [alpha]-Latrotoxin (CIRL), a Natural Chimera of the Cell Adhesion Protein and the G Protein-coupled Receptor. ROLE OF THE G PROTEIN-COUPLED RECEPTOR PROTEOLYSIS SITE (GPS) MOTIF by Krasnoperov, V, Lu, Y, Buryanovsky, L, Neubert, T A, Ichtchenko, K, Petrenko, A G

“…The calcium-independent receptor of [alpha]-latrotoxin (CIRL), a neuronal cell surface receptor implicated in the regulation of exocytosis, is a natural…”
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Protein-tyrosine Phosphatase-[sigma] Is a Novel Member of the Functional Family of [alpha]-Latrotoxin Receptors by Krasnoperov, V, Bittner, MA, Mo, W, Buryanovsky, L, Neubert, T A, Holz, R W, Ichtchenko, K, Petrenko, A G

“…Receptor-like protein-tyrosine phosphatase sigma (PTP[sigma]) is essential for neuronal development and function. Here we report that PTP[sigma] is a target of…”
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The evolutionary pressure to inactivate: A subclass of synaptotagmins with an amino acid substitution that abolishes Ca super(2+) binding by von Poser, C, Ichtchenko, K, Shao, Xuguang, Rizo, J, Suedhof, T C

“…Synaptotagmin I is a Ca super(2+)-binding protein of synaptic vesicles that serves as a Ca super(2+) sensor for neurotransmitter release and was the first…”
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Neurexin Ialpha is a major alpha-latrotoxin receptor that cooperates in alpha-latrotoxin action by Geppert, M, Khovotchev, M, Kransnoperov, V, Goda, Y, Missler, M, Hammer, R.E, Ichtchenko, K, Petrenko, A.G, Sudhof, T.C

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