Search Results - "Ichise, Hirotake"

Gastrin-releasing peptide regulates fear learning under stressed conditions via activation of the amygdalostriatal transition area by Goto, Fumiko, Kiyama, Yuji, Ogawa, Itone, Okuno, Hiroyuki, Ichise, Taeko, Ichise, Hirotake, Anai, Motonobu, Kodama, Tatsuhiko, Yoshida, Nobuaki, Bito, Haruhiko, Manabe, Toshiya

“…The amygdala, a critical brain region responsible for emotional behavior, is crucially involved in the regulation of the effects of stress on emotional…”
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Development of a Mouse Experimental System for the In Vivo Characterization of Bioengineered Adipose-Derived Stromal Cells by Ichise, Taeko, Ichise, Hirotake, Shimizu, Yusuke

“…Human adipose-derived stromal cells (ADSCs) are an important resource for cell-based therapies. However, the dynamics of ADSCs after transplantation and their…”
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Phospholipase Cγ2 is necessary for separation of blood and lymphatic vasculature in mice by Ichise, Hirotake, Ichise, Taeko, Ohtani, Osamu, Yoshida, Nobuaki

“…The lymphatic vasculature originates from the blood vasculature through a mechanism relying on Prox1 expression and VEGFC signalling, and is separated and kept…”
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Platelet Activation Receptor CLEC-2 Regulates Blood/Lymphatic Vessel Separation by Inhibiting Proliferation, Migration, and Tube Formation of Lymphatic Endothelial Cells by Osada, Makoto, Inoue, Osamu, Ding, Guo, Shirai, Toshiaki, Ichise, Hirotake, Hirayama, Kazuyoshi, Takano, Katsuhiro, Yatomi, Yutaka, Hirashima, Masanori, Fujii, Hideki, Suzuki-Inoue, Katsue, Ozaki, Yukio

“…The platelet activation receptor CLEC-2 plays crucial roles in thrombosis/hemostasis, tumor metastasis, and lymphangiogenesis, although its role in…”
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H-, N- and Kras cooperatively regulate lymphatic vessel growth by modulating VEGFR3 expression in lymphatic endothelial cells in mice by Ichise, Taeko, Yoshida, Nobuaki, Ichise, Hirotake

“…Mammalian Ras, which is encoded by three independent genes, has been thought to be a versatile component of intracellular signalling. However, when, where and…”
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Phospholipase Cγ2 Is Required for Luminal Expansion of the Epididymal Duct during Postnatal Development in Mice by Ichise, Hirotake, Ichise, Taeko, Yoshida, Nobuaki

“…Phospholipase Cγ2 (PLCγ2)-deficient mice exhibit misconnections of blood and lymphatic vessels, and male infertility. However, the cell type responsible for…”
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Ras/MAPK signaling modulates VEGFR-3 expression through Ets-mediated p300 recruitment and histone acetylation on the Vegfr3 gene in lymphatic endothelial cells by Ichise, Taeko, Yoshida, Nobuaki, Ichise, Hirotake

“…Modulation of VEGFR-3 expression is important for altering lymphatic endothelial cell (LEC) characteristics during the lymphangiogenic processes that occur…”
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S1PR1 regulates the quiescence of lymphatic vessels by inhibiting laminar shear stress-dependent VEGF-C signaling by Geng, Xin, Yanagida, Keisuke, Akwii, Racheal G, Choi, Dongwon, Chen, Lijuan, Ho, YenChun, Cha, Boksik, Mahamud, Md Riaj, Berman de Ruiz, Karen, Ichise, Hirotake, Chen, Hong, Wythe, Joshua D, Mikelis, Constantinos M, Hla, Timothy, Srinivasan, R Sathish

“…During the growth of lymphatic vessels (lymphangiogenesis), lymphatic endothelial cells (LECs) at the growing front sprout by forming filopodia. Those tip…”
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Temporal and spatial regulation of epsin abundance and VEGFR3 signaling are required for lymphatic valve formation and function by Liu, Xiaolei, Pasula, Satish, Song, Hoogeun, Tessneer, Kandice L, Dong, Yunzhou, Hahn, Scott, Yago, Tadayuki, Brophy, Megan L, Chang, Baojun, Cai, Xiaofeng, Wu, Hao, McManus, John, Ichise, Hirotake, Georgescu, Constantin, Wren, Jonathan D, Griffin, Courtney, Xia, Lijun, Srinivasan, R Sathish, Chen, Hong

“…Lymphatic valves prevent the backflow of the lymph fluid and ensure proper lymphatic drainage throughout the body. Local accumulation of lymphatic fluid in…”
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The Cd6 gene as a permissive locus for targeted transgenesis in the mouse by Ichise, Hirotake, Ichise, Taeko, Sasanuma, Hiroki, Yoshida, Nobuaki

“…Summary The introduction of a transgene into the genome through homologous recombination or sequence‐specific enzymatic modification is a key technique for…”
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Nucleoredoxin Negatively Regulates Toll-like Receptor 4 Signaling via Recruitment of Flightless-I to Myeloid Differentiation Primary Response Gene (88) by Hayashi, Tatsuya, Funato, Yosuke, Terabayashi, Takeshi, Morinaka, Akifumi, Sakamoto, Reiko, Ichise, Hirotake, Fukuda, Hiroyuki, Yoshida, Nobuaki, Miki, Hiroaki

“…We previously characterized nucleoredoxin (NRX) as a negative regulator of the Wnt signaling pathway through Dishevelled (Dvl). We perform a comprehensive…”
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Establishment of a tamoxifen-inducible Cre-driver mouse strain for widespread and temporal genetic modification in adult mice by Ichise, Hirotake, Hori, Akiko, Shiozawa, Seiji, Kondo, Saki, Kanegae, Yumi, Saito, Izumu, Ichise, Taeko, Yoshida, Nobuaki

“…Temporal genetic modification of mice using the ligand-inducible Cre/loxP system is an important technique that allows the bypass of embryonic lethal…”
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Development of a new method for isolation and long-term culture of organ-specific blood vascular and lymphatic endothelial cells of the mouse by Yamaguchi, Takashi, Ichise, Taeko, Iwata, Osamu, Hori, Akiko, Adachi, Tomomi, Nakamura, Masaru, Yoshida, Nobuaki, Ichise, Hirotake

“…Endothelial cells are indispensable components of the vascular system, and play pivotal roles during development and in health and disease. Their properties…”
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CBP/p300 antagonises EGFR‐Ras‐Erk signalling and suppresses increased Ras‐Erk signalling‐induced tumour formation in mice by Ichise, Taeko, Yoshida, Nobuaki, Ichise, Hirotake

“…CREB‐binding protein (CBP) and p300 have oncogenic properties; both co‐operate with pro‐oncogenic transcription factors downstream of Ras‐Erk signalling to…”
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Efficient Sequential Gene Regulation via FLP- and Cre-Recombinase Using Adenovirus Vector in Mammalian Cells Including Mouse ES Cells by Kondo, Saki, Takahashi, Yuzuka, Shiozawa, Seiji, Ichise, Hirotake, Yoshida, Nobuaki, Kanegae, Yumi, Saito, Izumu

“…Site‐specific recombinase is widely applied for the regulation of gene expression because its regulatory action is strict and efficient. However, each system…”
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FGF2-induced Ras-MAPK signalling maintains lymphatic endothelial cell identity by upregulating endothelial-cell-specific gene expression and suppressing TGFβ signalling through Smad2 by Ichise, Taeko, Yoshida, Nobuaki, Ichise, Hirotake

“…The lymphatic endothelial cell (LEC) fate decision program during development has been described. However, the mechanism underlying the maintenance of…”
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Phospholipase C[gamma]2 Is Required for Luminal Expansion of the Epididymal Duct during Postnatal Development in Mice by Ichise, Hirotake, Ichise, Taeko, Yoshida, Nobuaki

“…Phospholipase C[gamma]2 (PLC[gamma]2)-deficient mice exhibit misconnections of blood and lymphatic vessels, and male infertility. However, the cell type…”
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Nucleoredoxin Sustains Wnt/β-Catenin Signaling by Retaining a Pool of Inactive Dishevelled Protein by Funato, Yosuke, Terabayashi, Takeshi, Sakamoto, Reiko, Okuzaki, Daisuke, Ichise, Hirotake, Nojima, Hiroshi, Yoshida, Nobuaki, Miki, Hiroaki

“…Overexpression of Dishevelled (Dvl), an essential component of the Wnt signaling pathway, is frequently associated with tumors [1, 2], and thus the Dvl protein…”
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FGF2-induced Ras/Erk MAPK signalling maintains lymphatic endothelial cell identity by up-regulating endothelial cell-specific gene expression and suppressing TGFβ signalling via Smad2 by Ichise, Taeko, Yoshida, Nobuaki, Ichise, Hirotake

“…The lymphatic endothelial cell (LEC) fate decision program during development has been revealed. However, the mechanism underlying the maintenance of…”
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Use of genetically engineered mice for lymphatic vascular biology by Hirotake Ichise

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