Search Results - "Ichim, Gabriel"

A fate worse than death: apoptosis as an oncogenic process by Ichim, Gabriel, Tait, Stephen W. G.

“…Apoptotic cell death undoubtedly has beneficial roles in cancer, but paradoxically, apoptosis can also cause unwanted effects that could promote cancer. This…”
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Apoptosis – Fueling the oncogenic fire by Castillo Ferrer, Camila, Berthenet, Kevin, Ichim, Gabriel

“…Apoptosis, the most extensively studied form of programmed cell death, is essential for organismal homeostasis. Apoptotic cell death has widely been reported…”
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Die another way--non-apoptotic mechanisms of cell death by Tait, Stephen W G, Ichim, Gabriel, Green, Douglas R

“…Regulated, programmed cell death is crucial for all multicellular organisms. Cell death is essential in many processes, including tissue sculpting during…”
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Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness by Fanfone, Deborah, Wu, Zhichong, Mammi, Jade, Berthenet, Kevin, Neves, David, Weber, Kathrin, Halaburkova, Andrea, Virard, François, Bunel, Félix, Jamard, Catherine, Hernandez-Vargas, Hector, Tait, Stephen W G, Hennino, Ana, Ichim, Gabriel

“…Mechanical stress is known to fuel several hallmarks of cancer, ranging from genome instability to uncontrolled proliferation or invasion. Cancer cells are…”
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Limited Mitochondrial Permeabilization Causes DNA Damage and Genomic Instability in the Absence of Cell Death by Ichim, Gabriel, Lopez, Jonathan, Ahmed, Shafiq U., Muthalagu, Nathiya, Giampazolias, Evangelos, Delgado, M. Eugenia, Haller, Martina, Riley, Joel S., Mason, Susan M., Athineos, Dimitris, Parsons, Melissa J., van de Kooij, Bert, Bouchier-Hayes, Lisa, Chalmers, Anthony J., Rooswinkel, Rogier W., Oberst, Andrew, Blyth, Karen, Rehm, Markus, Murphy, Daniel J., Tait, Stephen W.G.

“…During apoptosis, the mitochondrial outer membrane is permeabilized, leading to the release of cytochrome c that activates downstream caspases. Mitochondrial…”
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Differential retrotranslocation of mitochondrial Bax and Bak by Todt, Franziska, Cakir, Zeynep, Reichenbach, Frank, Emschermann, Frederic, Lauterwasser, Joachim, Kaiser, Andrea, Ichim, Gabriel, Tait, Stephen WG, Frank, Stephan, Langer, Harald F, Edlich, Frank

“…The Bcl‐2 proteins Bax and Bak can permeabilize the outer mitochondrial membrane and commit cells to apoptosis. Pro‐survival Bcl‐2 proteins control Bax by…”
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Low biological fluctuation of mitochondrial CpG and non-CpG methylation at the single-molecule level by Goldsmith, Chloe, Rodríguez-Aguilera, Jesús Rafael, El-Rifai, Ines, Jarretier-Yuste, Adrien, Hervieu, Valérie, Raineteau, Olivier, Saintigny, Pierre, Chagoya de Sánchez, Victoria, Dante, Robert, Ichim, Gabriel, Hernandez-Vargas, Hector

“…Mammalian cytosine DNA methylation (5mC) is associated with the integrity of the genome and the transcriptional status of nuclear DNA. Due to technical…”
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Caspase-8 deficiency induces a switch from TLR3 induced apoptosis to lysosomal cell death in neuroblastoma by Locquet, Marie-Anaïs, Ichim, Gabriel, Bisaccia, Joseph, Dutour, Aurelie, Lebecque, Serge, Castets, Marie, Weber, Kathrin

“…In cancer cells only, TLR3 acquires death receptor properties by efficiently triggering the extrinsic pathway of apoptosis with Caspase-8 as apical protease…”
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Widespread Mitochondrial Depletion via Mitophagy Does Not Compromise Necroptosis by Tait, Stephen W.G., Oberst, Andrew, Quarato, Giovanni, Milasta, Sandra, Haller, Martina, Wang, Ruoning, Karvela, Maria, Ichim, Gabriel, Yatim, Nader, Albert, Matthew L., Kidd, Grahame, Wakefield, Randall, Frase, Sharon, Krautwald, Stefan, Linkermann, Andreas, Green, Douglas R.

“…Programmed necrosis (or necroptosis) is a form of cell death triggered by the activation of receptor interacting protein kinase-3 (RIPK3). Several reports have…”
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Spontaneous activity of the mitochondrial apoptosis pathway drives chromosomal defects, the appearance of micronuclei and cancer metastasis through the Caspase-Activated DNAse by Haimovici, Aladin, Höfer, Christoph, Badr, Mohamed Tarek, Bavafaye Haghighi, Elham, Amer, Tarek, Boerries, Melanie, Bronsert, Peter, Glavynskyi, Ievgen, Fanfone, Deborah, Ichim, Gabriel, Thilmany, Nico, Weber, Arnim, Brummer, Tilman, Spohr, Corinna, Öllinger, Rupert, Janssen, Klaus-Peter, Rad, Roland, Häcker, Georg

“…Micronuclei are DNA-containing structures separate from the nucleus found in cancer cells. Micronuclei are recognized by the immune sensor axis cGAS/STING,…”
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Blockade of Platelet CysLT1R Receptor with Zafirlukast Counteracts Platelet Protumoral Action and Prevents Breast Cancer Metastasis to Bone and Lung by Saier, Lou, Ribeiro, Johnny, Daunizeau, Thomas, Houssin, Audrey, Ichim, Gabriel, Barette, Caroline, Bouazza, Lamia, Peyruchaud, Olivier

“…Metastases are the main cause of death in cancer patients, and platelets are largely known for their contribution in cancer progression. However, targeting…”
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Mito-priming as a method to engineer Bcl-2 addiction by Lopez, Jonathan, Bessou, Margaux, Riley, Joel S., Giampazolias, Evangelos, Todt, Franziska, Rochegüe, Tony, Oberst, Andrew, Green, Douglas R., Edlich, Frank, Ichim, Gabriel, Tait, Stephen W. G.

“…Most apoptotic stimuli require mitochondrial outer membrane permeabilization (MOMP) in order to execute cell death. As such, MOMP is subject to tight control…”
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Spatial sequestration of activated-caspase 3 in aggresomes mediates resistance of neuroblastoma cell to bortezomib treatment by Berthenet, Kévin, Aïmontché, Eliézer, El Mrini, Sara, Brière, Johan, Pion, Nathalie, Iacono, Isabelle, Brejon, Stéphanie, Monier, Karine, Catez, Frédéric, Ichim, Gabriel, Combaret, Valérie, Mertani, Hichem C., Diaz, Jean-Jacques, Albaret, Marie Alexandra

“…Neuroblastoma (NB) is the most common pediatric tumor and is currently treated by several types of therapies including chemotherapies, such as bortezomib…”
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The stress sensor GCN2 differentially controls ribosome biogenesis in colon cancer according to the nutritional context by Piecyk, Marie, Triki, Mouna, Laval, Pierre‐Alexandre, Duret, Cedric, Fauvre, Joelle, Cussonneau, Laura, Machon, Christelle, Guitton, Jerôme, Rama, Nicolas, Gibert, Benjamin, Ichim, Gabriel, Catez, Frederic, Bourdelais, Fleur, Durand, Sebastien, Diaz, Jean‐Jacques, Coste, Isabelle, Renno, Toufic, Manié, Serge N., Aznar, Nicolas, Ansieau, Stephane, Ferraro‐Peyret, Carole, Chaveroux, Cedric

“…Nutrient availability is a key determinant of tumor cell behavior. While nutrient‐rich conditions favor proliferation and tumor growth, scarcity, and…”
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Hey1- and p53-dependent TrkC proapoptotic activity controls neuroblastoma growth by Ménard, Marie, Costechareyre, Clélia, Ichim, Gabriel, Blachier, Jonathan, Neves, David, Jarrosson-Wuilleme, Loraine, Depping, Reinhard, Koster, Jan, Saintigny, Pierre, Mehlen, Patrick, Tauszig-Delamasure, Servane

“…The neurotrophin-3 (NT-3) receptor tropomyosin receptor kinase C (TrkC/NTRK3) has been described as a dependence receptor and, as such, triggers apoptosis in…”
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Sometimes even apoptosis fails: implications for cancer by Berthenet, Kevin, Weber, Kathrin, Ichim, Gabriel

“…Apoptosis is vital for the correct morphogenesis of multi-cellular organisms. However, like most physiological programs, the cell's ability to commit suicide…”
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Dependence receptor TrkC is a putative colon cancer tumor suppressor by Genevois, Anne-Laure, Ichim, Gabriel, Coissieux, Marie-May, Lambert, Marie-Pierre, Lavial, Fabrice, Goldschneider, David, Jarrosson-Wuilleme, Loraine, Lepinasse, Florian, Gouysse, Géraldine, Herceg, Zdenko, Scoazec, Jean-Yves, Tauszig-Delamasure, Servane, Mehlen, Patrick

“…The TrkC neurotrophin receptor belongs to the functional dependence receptor family, members of which share the ability to induce apoptosis in the absence of…”
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In Cellulo Evaluation of the Therapeutic Potential of NHC Platinum Compounds in Metastatic Cutaneous Melanoma by Charignon, Elsa, Bouché, Mathilde, Clave-Darcissac, Caroline, Dahm, Georges, Ichim, Gabriel, Clotagatide, Anthony, Mertani, Hichem C, Telouk, Philippe, Caramel, Julie, Diaz, Jean-Jacques, Bellemin-Laponnaz, Stéphane, Bouvet, Philippe, Billotey, Claire

“…We describe here the evaluation of the cytotoxic efficacy of two platinum (II) complexes bearing an N-heterocyclic carbene (NHC) ligand, a pyridine ligand and…”
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CDYL2 Epigenetically Regulates MIR124 to Control NF-κB/STAT3-Dependent Breast Cancer Cell Plasticity by Siouda, Maha, Dujardin, Audrey D., Barbollat-Boutrand, Laetitia, Mendoza-Parra, Marco A., Gibert, Benjamin, Ouzounova, Maria, Bouaoud, Jebrane, Tonon, Laurie, Robert, Marie, Foy, Jean-Philippe, Lavergne, Vincent, Manie, Serge N., Viari, Alain, Puisieux, Alain, Ichim, Gabriel, Gronemeyer, Hinrich, Saintigny, Pierre, Mulligan, Peter

“…Epigenetic deregulation of gene transcription is central to cancer cell plasticity and malignant progression but remains poorly understood. We found that the…”
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Neurotrophin-3 production promotes human neuroblastoma cell survival by inhibiting TrkC-induced apoptosis by Bouzas-Rodriguez, Jimena, Cabrera, Jorge Ruben, Delloye-Bourgeois, Céline, Ichim, Gabriel, Delcros, Jean-Guy, Raquin, Marie-Anne, Rousseau, Raphaël, Combaret, Valérie, Bénard, Jean, Tauszig-Delamasure, Servane, Mehlen, Patrick

“…Tropomyosin-related kinase receptor C (TrkC) is a neurotrophin receptor with tyrosine kinase activity that was expected to be oncogenic. However, it has…”
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