Search Results - "Ichihara, Gaku"
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Environmental arsenic exposure and its contribution to human diseases, toxicity mechanism and management
Published in Environmental pollution (1987) (15-11-2021)“…Arsenic is a well-recognized environmental contaminant that occurs naturally through geogenic processes in the aquifer. More than 200 million people around the…”
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Higher viral load and infectivity increase risk of aerosol transmission for Delta and Omicron variants of SARS-CoV-2
Published in Swiss medical weekly (03-01-2022)“…Airborne transmission of SARS-CoV-2 is an important route of infection. For the wildtype (WT) only a small proportion of those infected emitted large…”
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Particle toxicology and health - where are we?
Published in Particle and fibre toxicology (23-04-2019)“…Particles and fibres affect human health as a function of their properties such as chemical composition, size and shape but also depending on complex…”
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Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis
Published in Proceedings of the National Academy of Sciences - PNAS (06-12-2011)“…Multiwalled carbon nanotubes (MWCNTs) have the potential for widespread applications in engineering and materials science. However, because of their…”
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The mechanism of low-level arsenic exposure-induced hypertension: Inhibition of the activity of the angiotensin-converting enzyme 2
Published in Chemosphere (Oxford) (01-03-2023)“…It is now well-established that arsenic exposure induces hypertension in humans. Although arsenic-induced hypertension is reported in many epidemiological…”
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Role of microglial activation and neuroinflammation in neurotoxicity of acrylamide in vivo and in vitro
Published in Archives of toxicology (01-07-2019)“…Acrylamide, a soft electrophile, is widely used in the industry and laboratories, and also contaminates certain foods. Neurotoxicity and neurodegenerative…”
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Toxicological Evaluation of SiO₂ Nanoparticles by Zebrafish Embryo Toxicity Test
Published in International journal of molecular sciences (18-02-2019)“…As the use of nanoparticles (NPs) is increasing, the potential toxicity and behavior of NPs in living systems need to be better understood. Our goal was to…”
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Nrf2 Activation Attenuates Acrylamide-Induced Neuropathy in Mice
Published in International journal of molecular sciences (01-06-2021)“…Acrylamide is a well characterized neurotoxicant known to cause neuropathy and encephalopathy in humans and experimental animals. To investigate the role of…”
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Factory site analysis of respirable fibers generated during the process of cutting and grinding of carbon fibers-reinforced plastics
Published in International archives of occupational and environmental health (01-09-2022)“…Objectives Carbon fibers are used in a variety of industrial applications, based on their lightweight and high stiffness properties. There is little…”
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Identification by TCGA database search of five genes that are aberrantly expressed and involved in hepatocellular carcinoma potentially via DNA methylation changes
Published in Environmental health and preventive medicine (23-07-2020)“…Abstract Background Various treatments for hepatocellular carcinoma (HCC) are utilized in clinical practice; however, the prognosis is still poor on account of…”
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Evaluation of hydroxyapatite nanoparticles - induced in vivo toxicity in Drosophila melanogaster
Published in Applied surface science (01-08-2019)“…Hydroxyapatite (HAp), a compound similar in composition to human hard tissues such as bone and teeth, has widespread applications in bulk as well as…”
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Genetic ablation of Nrf2 exacerbates neurotoxic effects of acrylamide in mice
Published in Toxicology (Amsterdam) (30-05-2021)“…[Display omitted] •Deletion of Nrf2 gene enhanced acrylamide-induced neurotoxicity.•Deletion of Nrf2 gene enhanced acrylamide-induced microglial…”
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Proteomic analysis of liver proteins of mice exposed to 1,2-dichloropropane
Published in Archives of toxicology (01-08-2020)“…1,2-Dichloropropane (1,2-DCP) is recognized as the causative agent for cholangiocarcinoma among offset color proof-printing workers in Japan. The aim of the…”
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Transcriptome analysis of human cholangiocytes exposed to carcinogenic 1,2-dichloropropane in the presence of macrophages in vitro
Published in Scientific reports (02-07-2022)“…1,2-Dichloropropane (1,2-DCP), a synthetic organic solvent, has been implicated in causality of cholangiocarcinoma (bile duct cancer). 1,2-DCP-induced…”
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Protective role of Nrf2 in zinc oxide nanoparticles-induced lung inflammation in female mice and sexual dimorphism in susceptibility
Published in Toxicology letters (01-11-2022)“…BACKGROUNDZinc oxide nanoparticles (ZnO-NPs) are currently employed in various products such as rubber, paint, and cosmetics. Our group reported recently that…”
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Long‐Chain Acyl Carnitines Aggravate Polystyrene Nanoplastics‐Induced Atherosclerosis by Upregulating MARCO
Published in Advanced science (01-07-2023)“…Exposure to micro‐ and nanoplastics (MNPs) is common because of their omnipresence in environment. Recent studies have revealed that MNPs may cause…”
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Role of Nrf2 in inflammatory response in lung of mice exposed to zinc oxide nanoparticles
Published in Particle and fibre toxicology (16-12-2019)“…Zinc oxide nanoparticles (ZnO-NPs) are widely used in many industrial sectors and previous studies have reported that exposure of the lungs to ZnO-NPs induces…”
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Zinc oxide nanoparticles induce migration and adhesion of monocytes to endothelial cells and accelerate foam cell formation
Published in Toxicology and applied pharmacology (01-07-2014)“…Metal oxide nanoparticles are widely used in industry, cosmetics, and biomedicine. However, the effects of exposure to these nanoparticles on the…”
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Exposure to Benzo[a]pyrene Decreases Noradrenergic and Serotonergic Axons in Hippocampus of Mouse Brain
Published in International journal of molecular sciences (01-06-2023)“…Epidemiological studies showed the association between air pollution and dementia. A soluble fraction of particulate matters including polycyclic aromatic…”
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Proteomic analysis of hippocampal proteins in acrylamide-exposed Wistar rats
Published in Archives of toxicology (01-07-2019)“…Acrylamide has been used industrially and also found in certain foods cooked at high temperatures. Previous reports described acrylamide-related human…”
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