Search Results - "Ibrahim, Wisam Nabeel"
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Characterization of neurobehavioral pattern in a zebrafish 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced model: A 96-hour behavioral study
Published in PloS one (03-10-2022)“…Parkinson’s disease (PD) is the most common brain motor disorder, characterized by a substantial loss of dopaminergic neurons in the substantia nigra pars…”
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Nrf-2-dependent antioxidant and anti-inflammatory effects underlie the protective effect of esculeoside A against retinal damage in streptozotocin-induced diabetic rats
Published in Biomedicine & pharmacotherapy (01-04-2024)“…Esculeoside A (ESA) is a tomato-derived glycoside with antioxidant and anti-inflammatory properties. The protective effect of ESA against diabetic retinopathy…”
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Cancer Resistance to Immunotherapy: Comprehensive Insights with Future Perspectives
Published in Pharmaceutics (01-04-2023)“…Cancer immunotherapy is a type of treatment that harnesses the power of the immune systems of patients to target cancer cells with better precision compared to…”
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Formulation, Characterization and Biological Activity Screening of Sodium Alginate-Gum Arabic Nanoparticles Loaded with Curcumin
Published in Molecules (Basel, Switzerland) (10-05-2020)“…The approach of drug delivery systems emphasizes the use of nanoparticles as a vehicle, offering the optional property of delivering drugs as a single dose…”
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Thymoquinone, as a Novel Therapeutic Candidate of Cancers
Published in Pharmaceuticals (Basel, Switzerland) (16-04-2021)“…To date, natural products are widely used as pharmaceutical agents for many human diseases and cancers. One of the most popular natural products that have been…”
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The Promise of the Zebrafish Model for Parkinson's Disease: Today's Science and Tomorrow's Treatment
Published in Frontiers in genetics (15-04-2021)“…The second most prevalent neurodegenerative disorder in the elderly is Parkinson's disease (PD). Its etiology is unclear and there are no available…”
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Breaking Barriers: The Promise and Challenges of Immune Checkpoint Inhibitors in Triple-Negative Breast Cancer
Published in Biomedicines (01-02-2024)“…Triple-negative breast cancer (TNBC) is a highly aggressive malignancy with pronounced immunogenicity, exhibiting rapid proliferation and immune cell…”
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Curcumin as a novel therapeutic candidate for cancer: can this natural compound revolutionize cancer treatment?
Published in Frontiers in oncology (23-10-2024)“…Cancer remains one of the leading causes of death worldwide. Despite advances in medical treatments, current therapeutic strategies, including radiotherapy,…”
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Serum Uric Acid Level Is Positively Associated With Higher Bone Mineral Density at Multiple Skeletal Sites Among Healthy Qataris
Published in Frontiers in endocrinology (Lausanne) (31-03-2021)“…Oxidative stress has been implicated as a fundamental mechanism in the decline of bone mass. Although serum uric acid (SUA) has potent antioxidant properties,…”
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Gene Expression Profiling and Protein Analysis Reveal Suppression of the C-Myc Oncogene and Inhibition JAK/STAT and PI3K/AKT/mTOR Signaling by Thymoquinone in Acute Myeloid Leukemia Cells
Published in Pharmaceuticals (Basel, Switzerland) (03-03-2022)“…Overexpression of c-Myc plays an essential role in leukemogenesis and drug resistance, making c-Myc an attractive target for cancer therapy. However, targeting…”
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Oxidative stress cytotoxicity induced by platinum-doped magnesia nanoparticles in cancer cells
Published in Biomedicine & pharmacotherapy (01-06-2021)“…The aim of this study was to prepare, characterize, and determine the in vitro anticancer effects of platinum-doped magnesia (Pt/MgO) nanoparticles. The…”
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Sex distinctive patterns in the association between serum bicarbonate and uric acid levels among healthy adults. Qatar biobank data
Published in Frontiers in medicine (02-06-2023)“…Uric acid is the final product of purine metabolism and is a potent plasma antioxidant but with pro-inflammatory effects. At high levels, it may increase the…”
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Mangifera indica L . kernel ethanol extract inhibits cell viability and proliferation with induction of cell cycle arrest and apoptosis in lung cancer cells
Published in Molecular & cellular oncology (2024)“…In this study, we investigated the effects of an ethanolic extract of kernel on the viability and proliferation of human lung cancer cells. We utilized MTT and…”
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COVID-19 Vaccine Acceptance among Vulnerable Groups: Syrian Refugees in Jordan
Published in Vaccines (Basel) (28-09-2022)“…Despite the wide distribution of COVID-19 vaccines, refugees remain last in line for the intake of vaccines. Syrian refugees in Jordan reach up to 700,000…”
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Preparation, characterization, in vitro drug release and anti-inflammatory of thymoquinone-loaded chitosan nanocomposite
Published in Saudi pharmaceutical journal (01-04-2022)“…In this study, we formulated Thymoquinone-loaded nanocomposites (TQ-NCs) using high-pressure homogenizer without sodium tripolyphosphate. The TQ-NCs were…”
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Curcumin gum Arabic nanoparticles demonstrate potent antioxidant and cytotoxic properties in human cancer cells
Published in Biocell (2022)“…The main purpose of the study was to enhance the stability and therapeutic effects of Curcumin (Cur) through nanoformulation with gum Arabic (GA) as a coating…”
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Physicochemical characterization and cancer cell antiproliferative effect of silver-doped magnesia nanoparticles
Published in Heliyon (01-05-2023)“…Silver-doped magnesia nanoparticles (Ag/MgO) were synthesized using the precipitation method and characterized by various techniques such as X-ray diffraction…”
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A Cross-Sectional Study on Bullying and Psychological Disturbances among Malaysian School Children
Published in Makara journal of health research (01-04-2021)“…Background: Bullying is a common violence in school and has become a major public health and global concern. Bullying influences mental health and is…”
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Obesity is associated with depression in Malaysian schoolchildren: A cross-sectional study
Published in Makara journal of health research (01-04-2020)“…Background: Overweight and obesity, which may lead to depression, have become prevalent among children worldwide. Hence, this study aimed to measure obesity…”
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Effect of shRNA Mediated Silencing of YB-1 Protein on the Expression of Matrix Collagenases in Malignant Melanoma Cell In Vitro
Published in Cells (Basel, Switzerland) (10-01-2018)“…YB-1 is a transcription and oncogenic factor capable of binding to DNA and RNA performing versatile functions within normal and cancer cells. Some studies…”
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