Search Results - "Ibrahim, Tamer M."

In silico identification of novel SARS-COV-2 2′-O-methyltransferase (nsp16) inhibitors: structure-based virtual screening, molecular dynamics simulation and MM-PBSA approaches by El Hassab, Mahmoud A., Ibrahim, Tamer M., Al-Rashood, Sara T., Alharbi, Amal, Eskandrani, Razan O., Eldehna, Wagdy M.

“…The novel coronavirus disease COVID-19, caused by the virus SARS CoV-2, has exerted a significant unprecedented economic and medical crisis, in addition to its…”
Get full text

Development of Novel Quinoline-Based Sulfonamides as Selective Cancer-Associated Carbonic Anhydrase Isoform IX Inhibitors by Shaldam, Moataz, Nocentini, Alessio, Elsayed, Zainab M, Ibrahim, Tamer M, Salem, Rofaida, El-Domany, Ramadan A, Capasso, Clemente, Supuran, Claudiu T, Eldehna, Wagdy M

“…A new series of quinoline-based benzenesulfonamides ( ) were developed as potential carbonic anhydrase inhibitors (CAIs). The target CAIs is based on the…”
Get full text

In Silico Targeting of Fascin Protein for Cancer Therapy: Benchmarking, Virtual Screening and Molecular Dynamics Approaches by Hassan, Heba H A, Ismail, Muhammad I, Abourehab, Mohammed A S, Boeckler, Frank M, Ibrahim, Tamer M, Arafa, Reem K

“…Fascin is an actin-bundling protein overexpressed in various invasive metastatic carcinomas through promoting cell migration and invasion. Therefore, blocking…”
Get full text

Spiro heterocycles bearing piperidine moiety as potential scaffold for antileishmanial activity: synthesis, biological evaluation, and in silico studies by Mohamed, Mounir A. A., Kadry, Asmaa M., Bekhit, Salma A., Abourehab, Mohammed A. S., Amagase, Kikuko, Ibrahim, Tamer M., El-Saghier, Ahmed M. M., Bekhit, Adnan A.

“…New spiro-piperidine derivatives were synthesised via the eco-friendly ionic liquids in a one-pot fashion. The in vitro antileishmanial activity against…”
Get full text

Discovery of new pyridine-quinoline hybrids as competitive and non-competitive PIM-1 kinase inhibitors with apoptosis induction and caspase 3/7 activation capabilities by El-Miligy, Mostafa M. M., Abdelaziz, Marwa E., Fahmy, Salwa M., Ibrahim, Tamer M., Abu-Serie, Marwa M., Mahran, Mona A., Hazzaa, Aly A.

“…New quinoline-pyridine hybrids were designed and synthesised as PIM-1/2 kinase inhibitors. Compounds 5b, 5c, 6e, 13a, 13c, and 14a showed in-vitro low…”
Get full text

New pyrazolylpyrazoline derivatives as dual acting antimalarial-antileishamanial agents: synthesis, biological evaluation and molecular modelling simulations by Bekhit, Adnan A., Lodebo, Eskedar T., Hymete, Ariaya, Ragab, Hanan M., Bekhit, Salma A., Amagase, Kikuko, Batubara, Afnan, Abourehab, Mohammed A. S., Bekhit, Alaa El-Din A., Ibrahim, Tamer M.

“…Promising inhibitory activities of the parasite multiplication were obtained upon evaluation of in vivo antimalarial activities of new pyrazolylpyrazoline…”
Get full text

Design and synthesis of phthalazine-based compounds as potent anticancer agents with potential antiangiogenic activity via VEGFR-2 inhibition by Elmeligie, Salwa, Aboul-Magd, Asmaa M., Lasheen, Deena S., Ibrahim, Tamer M., Abdelghany, Tamer M., Khojah, Sohair M., Abouzid, Khaled A. M.

“…In the designed compounds, either a biarylamide or biarylurea moiety or an N-substituted piperazine motif was linked to position 1 of the phthalazine core. The…”
Get full text

In silico identification of potential SARS COV-2 2'- O -methyltransferase inhibitor: fragment-based screening approach and MM-PBSA calculations by El Hassab, Mahmoud A, Ibrahim, Tamer M, Shoun, Aly A, Al-Rashood, Sara T, Alkahtani, Hamad M, Alharbi, Amal, Eskandrani, Razan O, Eldehna, Wagdy M

“…In the present era, there are many efforts trying to face the emerging and successive waves of the COVID-19 pandemic. This has led to considering new and…”
Get full text

Structure-guided approach on the role of substitution on amide-linked bipyrazoles and its effect on their anti-inflammatory activity by Domiati, Souraya A., Abd El Galil, Khaled H., Abourehab, Mohammed A. S., Ibrahim, Tamer M., Ragab, Hanan M.

“…A structure-guided modelling approach using COX-2 as a template was used to investigate the effect of replacing the chloro atom located at the chlorophenyl…”
Get full text

Supporting SARS-CoV-2 Papain-Like Protease Drug Discovery: In silico Methods and Benchmarking by Ibrahim, Tamer M., Ismail, Muhammad I., Bauer, Matthias R., Bekhit, Adnan A., Boeckler, Frank M.

“…The coronavirus disease 19 (COVID-19) is a rapidly growing pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Its papain-like…”
Get full text

Synthesis, anti-inflammatory screening, molecular docking, and COX-1,2/-5-LOX inhibition profile of some novel quinoline derivatives by Chaaban, Ibrahim, Rizk, Ola H., Ibrahim, Tamer M., Henen, Shery S., El-Khawass, El-Sayeda M., Bayad, Aida E., El-Ashmawy, Ibrahim M., Nematalla, Hisham A.

“…New quinoline compounds comprising pyrazole scaffold through different linkers were synthesized and evaluated for their anti-inflammatory activity. In vitro…”
Get full text

Design, synthesis and biological evaluation of novel pyridine derivatives as anticancer agents and phosphodiesterase 3 inhibitors by Abadi, Ashraf H., Ibrahim, Tamer M., Abouzid, Khaled M., Lehmann, Jochen, Tinsley, Heather N., Gary, Bernard D., Piazza, Gary A.

“…Two series of 4,6-diaryl-2-imino-1,2-dihydropyridine-3-carbonitriles and their isosteric 4,6-diaryl-2-oxo-1,2-dihydropyridine-3-carbonitriles were synthesized…”
Get full text

Using CADD tools to inhibit the overexpressed genes FAP, FN1, and MMP1 by repurposing ginsenoside C and Rg1 as a treatment for oral cancer by Abouelwafa, Manal, Ibrahim, Tamer M., El-Hadidi, Mohamed S., Mahnashi, Mater H., Owaidah, Amani Y., Saeedi, Nizar H., Attia, Hany G., Georrge, John J., Mostafa, Amany

“…Oral cancer is one of the most common cancer types. Many factors can express certain genes that cause the proliferation of oral tissues. Overexpressed genes…”
Get full text

New antileishmanial quinoline linked isatin derivatives targeting DHFR-TS and PTR1: Design, synthesis, and molecular modeling studies by Sabt, Ahmed, Eldehna, Wagdy M., Ibrahim, Tamer M., Bekhit, Adnan A., Batran, Rasha Z.

“…In a search for new drug candidates for one of the neglected tropical diseases, leishmaniasis, twenty quinoline-isatin hybrids were synthesized and tested for…”
Get full text

Leishmania treatment and prevention: Natural and synthesized drugs by Bekhit, Adnan A., El-Agroudy, Eman, Helmy, Aliaa, Ibrahim, Tamer M., Shavandi, Amin, Bekhit, Alaa El-Din A.

“…Leishmaniasis affects over 150 million people all over the world, especially in subtropical regions. Currently used antileishmanial synthesized drugs are…”
Get full text

Mining ZINC Database to Discover Potential Phosphodiesterase 9 Inhibitors Using Structure-Based Drug Design Approach by Hassaan, Engi A, Sigler, Sara C, Ibrahim, Tamer M, Lee, Kevin J, Cichon, Lauren K, Gary, Bernard D, Canzoneri, Joshua C, Piazza, Gary A, Abadi, Ashraf H

“…In view of the emerging clinical indications for Phosphodiesterase 9 inhibitors e.g. treatment of Alzheimer, diabetes, cancer, and the limited number of its…”
Get more information

Discovery of indolinone-bearing benzenesulfonamides as new dual carbonic anhydrase and VEGFR-2 inhibitors possessing anticancer and pro-apoptotic properties by Saied, Samaa, Shaldam, Moataz, Elbadawi, Mostafa M, Giovannuzzi, Simone, Nocentini, Alessio, Almahli, Hadia, Salem, Rofaida, Ibrahim, Tamer M, Supuran, Claudiu T, Eldehna, Wagdy M

“…In the current medical era, the utilization of a single small molecule to simultaneously target two distinct molecular targets is emerging as a highly…”
Get full text

Evaluation and Optimization of Virtual Screening Workflows with DEKOIS 2.0 – A Public Library of Challenging Docking Benchmark Sets by Bauer, Matthias R, Ibrahim, Tamer M, Vogel, Simon M, Boeckler, Frank M

“…The application of molecular benchmarking sets helps to assess the actual performance of virtual screening (VS) workflows. To improve the efficiency of…”
Get full text

Development of novel benzofuran-based SLC-0111 analogs as selective cancer-associated carbonic anhydrase isoform IX inhibitors by Shaldam, Moataz, Eldehna, Wagdy M., Nocentini, Alessio, Elsayed, Zainab M., Ibrahim, Tamer M., Salem, Rofaida, El-Domany, Ramadan A., Capasso, Clemente, Abdel-Aziz, Hatem A., Supuran, Claudiu T.

“…In the present study, we describe the design of different series of benzofuran-based derivatives as potential carbonic anhydrase inhibitors (CAIs). The adopted…”
Get full text

1,5-Diaryl-1,2,4-triazole Ureas as New SLC-0111 Analogues Endowed with Dual Carbonic Anhydrase and VEGFR‑2 Inhibitory Activities by Elsawi, Ahmed E., Elbadawi, Mostafa M., Nocentini, Alessio, Almahli, Hadia, Giovannuzzi, Simone, Shaldam, Moataz, Salem, Rofaida, Ibrahim, Tamer M., Abdel-Aziz, Hatem A., Supuran, Claudiu T., Eldehna, Wagdy M.

“…Presently, dual targeting by a single small molecule stands out as an effective cancer-fighting weapon. Carbonic anhydrase (CA) and vascular-endothelial growth…”
Get full text