Search Results - "Ibrahim, Samar H."

Animal Models of Nonalcoholic Steatohepatitis: Eat, Delete, and Inflame by Ibrahim, Samar H., Hirsova, Petra, Malhi, Harmeet, Gores, Gregory J.

“…With the obesity epidemic, nonalcoholic fatty liver disease (NAFLD) has become a public health problem with increasing prevalence. The mechanism of disease…”
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Lipid-Induced Signaling Causes Release of Inflammatory Extracellular Vesicles From Hepatocytes by Hirsova, Petra, Ibrahim, Samar H, Krishnan, Anuradha, Verma, Vikas K, Bronk, Steven F, Werneburg, Nathan W, Charlton, Michael R, Shah, Vijay H, Malhi, Harmeet, Gores, Gregory J

“…Background & Aims Hepatocyte cellular dysfunction and death induced by lipids and macrophage-associated inflammation are characteristics of nonalcoholic…”
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Lipid-induced endothelial vascular cell adhesion molecule 1 promotes nonalcoholic steatohepatitis pathogenesis by Furuta, Kunimaro, Guo, Qianqian, Pavelko, Kevin D, Lee, Jeong-Heon, Robertson, Keith D, Nakao, Yasuhiko, Melek, Jan, Shah, Vijay H, Hirsova, Petra, Ibrahim, Samar H

“…Monocyte homing to the liver and adhesion to the liver sinusoidal endothelial cells (LSECs) are key elements in nonalcoholic steatohepatitis (NASH)…”
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Mixed lineage kinase 3 mediates release of C‐X‐C motif ligand 10–bearing chemotactic extracellular vesicles from lipotoxic hepatocytes by Ibrahim, Samar H., Hirsova, Petra, Tomita, Kyoko, Bronk, Steven F., Werneburg, Nathan W., Harrison, Stephen A., Goodfellow, Val S., Malhi, Harmeet, Gores, Gregory J.

“…Mixed lineage kinase 3 (MLK3) deficiency reduces macrophage‐associated inflammation in a murine model of nonalcoholic steatohepatitis (NASH). However, the…”
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North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Position Paper on the Diagnosis and Management of Pediatric Acute Liver Failure by Squires, James E., Alonso, Estella M., Ibrahim, Samar H., Kasper, Vania, Kehar, Mohit, Martinez, Mercedes, Squires, Robert H.

“…ABSTRACT Pediatric acute liver failure (PALF) is a rare, rapidly progressive clinical syndrome with significant morbidity and mortality. The phenotype of PALF…”
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Mechanisms of Lipotoxicity in NAFLD and Clinical Implications by Ibrahim, Samar H., Kohli, Rohit, Gores, Gregory J.

“…ABSTRACT With the epidemic of childhood obesity, nonalcoholic fatty liver disease (NAFLD) has become the most common cause of chronic liver disease in…”
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Liver sinusoidal endothelial cell expressed vascular cell adhesion molecule 1 promotes liver fibrosis by Guo, Qianqian, Furuta, Kunimaro, Islam, Shahidul, Caporarello, Nunzia, Kostallari, Enis, Dielis, Kobe, Tschumperlin, Daniel J, Hirsova, Petra, Ibrahim, Samar H

“…During liver injury, liver sinusoidal endothelial cells (LSECs) dysfunction and capillarization promote liver fibrosis. We have previously reported that the…”
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Mixed Lineage Kinase 3 Mediates the Induction of CXCL10 by a STAT1‐Dependent Mechanism During Hepatocyte Lipotoxicity by Tomita, Kyoko, Kabashima, Ayano, Freeman, Brittany L., Bronk, Steven F., Hirsova, Petra, Ibrahim, Samar H.

“…ABSTRACT Saturated fatty acids (SFA) and their toxic metabolites contribute to hepatocyte lipotoxicity in nonalcoholic steatohepatitis (NASH). We previously…”
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A Surgical Model in Male Obese Rats Uncovers Protective Effects of Bile Acids Post-Bariatric Surgery by Kohli, Rohit, Setchell, Kenneth DR, Kirby, Michelle, Myronovych, Andriy, Ryan, Karen K, Ibrahim, Samar H, Berger, Jose, Smith, Kathi, Toure, Mouhamadoul, Woods, Stephen C, Seeley, Randy J

“…Bariatric surgery elevates serum bile acids. Conjugated bile acid administration, such as tauroursodeoxycholic acid (TUDCA), improves insulin sensitivity,…”
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Emerging Roles of Liver Sinusoidal Endothelial Cells in Nonalcoholic Steatohepatitis by Furuta, Kunimaro, Guo, Qianqian, Hirsova, Petra, Ibrahim, Samar H

“…Nonalcoholic steatohepatitis (NASH) has become a growing public health problem worldwide, yet its pathophysiology remains unclear. Liver sinusoidal endothelial…”
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Mixed lineage kinase 3 deficient mice are protected against the high fat high carbohydrate diet-induced steatohepatitis by Ibrahim, Samar H., Gores, Gregory J., Hirsova, Petra, Kirby, Michelle, Miles, Lili, Jaeschke, Anja, Kohli, Rohit

“…Background & Aims C‐Jun N‐terminal kinase (JNK) activation is pivotal in the development of nonalcoholic steatohepatitis (NASH). Mixed lineage kinase 3 (MLK) 3…”
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Who pulls the trigger: JNK activation in liver lipotoxicity? by Ibrahim, Samar H, Gores, Gregory J

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The evolving role of liver sinusoidal endothelial cells in liver health and disease by McConnell, Matthew J, Kostallari, Enis, Ibrahim, Samar H, Iwakiri, Yasuko

“…LSECs are a unique population of endothelial cells within the liver and are recognized as key regulators of liver homeostasis. LSECs also play a key role in…”
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Glycogen synthase kinase 3 activity enhances liver inflammation in MASH by Khoury, Mireille, Guo, Qianqian, Furuta, Kunimaro, Correia, Cristina, Meroueh, Chady, Kim Lee, Hyun Se, Warasnhe, Khaled, Valenzuela-Pérez, Lucía, Mazar, Andrew P., Kim, Iljung, Noh, Yung-Kyun, Holmes, Heather, Romero, Michael F., Sussman, Caroline R., Pavelko, Kevin D., Islam, Shahidul, Bamidele, Adebowale O., Hirsova, Petra, Li, Hu, Ibrahim, Samar H.

“…Metabolic dysfunction-associated steatohepatitis (MASH) is characterized by excessive circulating toxic lipids, hepatic steatosis, and liver inflammation…”
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A Molecular Signature of Mouse NASH: A Step Closer to a Human Predictive Biomarker? by Ibrahim, Samar H., MB, ChB, Malhi, Harmeet, MBBS

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Vismodegib suppresses TRAIL-mediated liver injury in a mouse model of nonalcoholic steatohepatitis by Hirsova, Petra, Ibrahim, Samar H, Bronk, Steven F, Yagita, Hideo, Gores, Gregory J

“…Hedgehog signaling pathway activation has been implicated in the pathogenesis of NASH. Despite this concept, hedgehog pathway inhibitors have not been…”
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The Global Alagille Alliance study: Redefining the natural history of Alagille syndrome by Habash, Nawras, Ibrahim, Samar H

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Perinatal Nutritional Reprogramming of the Epigenome Promotes Subsequent Development of Nonalcoholic Steatohepatitis by Gutierrez Sanchez, Luz Helena, Tomita, Kyoko, Guo, Qianqian, Furuta, Kunimaro, Alhuwaish, Husam, Hirsova, Petra, Baheti, Saurabh, Alver, Bonnie, Hlady, Ryan, Robertson, Keith D., Ibrahim, Samar H.

“…With the epidemic of obesity, nonalcoholic fatty liver disease (NAFLD) has become the most common pediatric liver disease. The influence of a perinatal…”
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Integrin β1-enriched extracellular vesicles mediate monocyte adhesion and promote liver inflammation in murine NASH by Guo, Qianqian, Furuta, Kunimaro, Lucien, Fabrice, Gutierrez Sanchez, Luz Helena, Hirsova, Petra, Krishnan, Anuradha, Kabashima, Ayano, Pavelko, Kevin D., Madden, Benjamin, Alhuwaish, Husam, Gao, Yandong, Revzin, Alexander, Ibrahim, Samar H.

“…[Display omitted] •Hepatocytes under lipotoxic stress release active ITGβ1-enriched EVs.•Lipotoxic hepatocyte-derived EVs enhance monocyte adhesion to liver…”
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Severe Acute Hepatitis of Unknown Etiology in Children: New Virus or Immune Dysregulation by Gutierrez Sanchez, Luz Helena, Ibrahim, Samar H.

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