Search Results - "Iborra, Cécile"
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fast, single-vesicle fusion assay mimics physiological SNARE requirements
Published in Proceedings of the National Academy of Sciences - PNAS (23-02-2010)“…Almost all known intracellular fusion reactions are driven by formation of trans-SNARE complexes through pairing of vesicle-associated v-SNAREs with…”
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High-Resolution Proteomics Unravel a Native Functional Complex of Cav1.3, SK3, and Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels in Midbrain Dopaminergic Neurons
Published in Cells (Basel, Switzerland) (30-05-2024)“…Pacemaking activity in substantia nigra dopaminergic neurons is generated by the coordinated activity of a variety of distinct somatodendritic voltage- and…”
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A Role for the V0 Sector of the V-ATPase in Neuroexocytosis: Exogenous V0d Blocks Complexin and SNARE Interactions with V0c
Published in Cells (Basel, Switzerland) (26-02-2023)“…V-ATPase is an important factor in synaptic vesicle acidification and is implicated in synaptic transmission. Rotation in the extra-membranous V1 sector drives…”
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Ca2+/Calmodulin Transfers the Membrane-Proximal Lipid-Binding Domain of the v-SNARE Synaptobrevin from Cis to Trans Bilayers
Published in Proceedings of the National Academy of Sciences - PNAS (10-02-2004)“…Soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor (SNARE) protein interactions at the synaptic vesicle/plasma membrane interface…”
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Gangliosides interact with synaptotagmin to form the high-affinity receptor complex for botulinum neurotoxin B
Published in Proceedings of the National Academy of Sciences - PNAS (03-09-2019)“…Botulinum neurotoxin type B (BoNT/B) recognizes nerve terminals by binding to 2 receptor components: a polysialoganglioside, predominantly GT1b, and…”
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Synaptotagmin I and IV define distinct populations of neuronal transport vesicles
Published in The European journal of neuroscience (01-04-2000)“…Mammalian synaptotagmins constitute a multigene family of at least 11 membrane proteins. We have characterized synaptotagmin IV using antibodies directed…”
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Developmental Regulation of Synaptotagmin I, II, III, and IV mRNAs in the Rat CNS
Published in The Journal of neuroscience (15-02-1997)“…Synaptotagmin I is an abundant synaptic vesicle protein that has an essential function in mediating Ca2+-triggered neurotransmitter release. We have analyzed…”
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V-ATPase Membrane Sector Associates with Synaptobrevin to Modulate Neurotransmitter Release
Published in Neuron (Cambridge, Mass.) (29-07-2010)“…Acidification of synaptic vesicles by the vacuolar proton ATPase is essential for loading with neurotransmitter. Debated findings have suggested that V-ATPase…”
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Calmodulin-dependent regulation of a lipid binding domain in the v-SNARE synaptobrevin and its role in vesicular fusion
Published in Biology of the Cell (01-10-2003)“…Trans SNARE complex assembly is an essential step in Ca 2+-dependant membrane fusion, although the SNARE proteins do not bind Ca 2+ ions. Studies to evaluate…”
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Calcium-dependent Regulation of SNARE-mediated Membrane Fusion by Calmodulin
Published in The Journal of biological chemistry (30-07-2010)“…Neuroexocytosis requires SNARE proteins, which assemble into trans complexes at the synaptic vesicle/plasma membrane interface and mediate bilayer fusion. Ca2+…”
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MAU-8 is a Phosducin-like Protein required for G protein signaling in C. elegans
Published in Developmental biology (01-06-2006)“…The mau-8(qm57) mutation inhibits the function of GPB-2, a heterotrimeric G protein β subunit, and profoundly affects behavior through the Gαq/Gαo signaling…”
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A Fast, Single-Vesicle Fusion Assay Mimics Physiological SNARE Requirements
Published in Biophysical journal (01-01-2010)Get full text
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α-Latrotoxin forms calcium-permeable membrane pores via interactions with latrophilin or neurexin
Published in The European journal of neuroscience (01-11-2000)“…In order to explore the mechanisms by which α‐latrotoxin activates neurotransmitter release, we have characterized its effects by patch‐clamp methods on cells…”
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Ca 2+ /calmodulin transfers the membrane-proximal lipid-binding domain of the v-SNARE synaptobrevin from cis to trans bilayers
Published in Proceedings of the National Academy of Sciences - PNAS (10-02-2004)“…Soluble N -ethylmaleimide-sensitive fusion protein attachment protein receptor (SNARE) protein interactions at the synaptic vesicle/plasma membrane interface…”
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Calmodulin and lipid binding to synaptobrevin regulates calcium‐dependent exocytosis
Published in The EMBO journal (01-08-2002)“…Neurotransmitter release involves the assembly of a heterotrimeric SNARE complex composed of the vesicle protein synaptobrevin (VAMP 2) and two plasma membrane…”
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Calmodulin and lipid binding to synaptobrevin regulates calcium-dependent exocytosis
Published in The EMBO journal (01-08-2002)Get full text
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(Alpha)-latrotoxin forms calcium-permeable membrane pores via interactions with latrophilin or neurexin
Published in The European journal of neuroscience (01-11-2000)Get full text
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Antibodies against the beta subunit of voltage-dependent calcium channels in Lambert-Eaton myasthenic syndrome
Published in Neuroscience (1999)“…Lambert-Eaton myasthenic syndrome is an autoimmune disease that impairs neuromuscular transmission. Several studies suggest that neurotransmitter release is…”
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Redistribution of presynaptic proteins during α-latrotoxin-induced release of neurotransmitter and membrane retrieval at the frog neuromuscular junction
Published in The European journal of neuroscience (01-10-1999)“…Calcium‐dependent exocytosis at the nerve terminal involves the synaptic core (SNARE) complex composed of the t‐SNAREs syntaxin 1 and synaptosome‐associated…”
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