Search Results - "Ibler, E.M."

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    Typhoid toxin hijacks Wnt5a to establish host senescence and Salmonella infection

    Typhoid toxin hijacks Wnt5a to establish host senescence and Salmonella infection by ElGhazaly, Mohamed, Collins, Mark O., Ibler, Angela E.M., Humphreys, Daniel

    Published in Cell reports (Cambridge) (31-10-2023)
    “…Damage to our genome causes acute senescence in mammalian cells, which undergo growth arrest and release a senescence-associated secretory phenotype (SASP)…”
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    Typhoid toxin exhausts the RPA response to DNA replication stress driving senescence and Salmonella infection

    Typhoid toxin exhausts the RPA response to DNA replication stress driving senescence and Salmonella infection by Ibler, Angela E. M., ElGhazaly, Mohamed, Naylor, Kathryn L., Bulgakova, Natalia A., F. El-Khamisy, Sherif, Humphreys, Daniel

    Published in Nature communications (06-09-2019)
    “…Salmonella Typhi activates the host DNA damage response through the typhoid toxin, facilitating typhoid symptoms and chronic infections. Here we reveal a…”
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