Search Results - "Ibeanu, Gordon C."

Tumour Immunotherapy and Applications of Immunological Products: A Review of Literature by Oli, Angus Nnamdi, Adejumo, Samson Adedeji, Rowaiye, Adekunle Babajide, Ogidigo, Joyce Oloaigbe, Hampton-Marcell, Jarrad, Ibeanu, Gordon C

“…Malignant tumors, characterized by uncontrolled cell proliferation, are a leading global health challenge, responsible for over 9.7 million deaths in 2022,…”
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B355252 Suppresses LPS-Induced Neuroinflammation in the Mouse Brain by He, Qingping, Qi, Qi, Ibeanu, Gordon C, Li, P Andy

“…B355252 is a small molecular compound known for potentiating neural growth factor and protecting against neuronal cell death induced by glutamate in vitro and…”
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A novel phenoxy thiophene sulphonamide molecule protects against glutamate evoked oxidative injury in a neuronal cell model by Gliyazova, Nailya S, Huh, Eun Y, Ibeanu, Gordon C

“…Glutamate is one of the major neurotransmitters in the central nervous system. It is a potent neurotoxin capable of neuronal destruction through numerous…”
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Emergency medicine: magnesium sulphate injections and their pharmaceutical quality concerns by Oli, Angus Nnamdi, Nwankwo, Ezinne Janefrances, Umeyor, Chukwuebuka Emmanuel, Umeh, Ugochukwu Stanley, Okoyeh, Jude Nnaemeka, Ofomata, Chijioke M., Okoro, Chukwuemeka Chukwubuikem, Otakagu, Emmanuel Chinedum, Afunwa, Ruth Asikiya, Ibeanu, Gordon C.

“…World Health Organization has recognized magnesium sulphate as the drug of choice for prevention and treatment of fits associated with preeclampsia and…”
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Transcriptional Response of Selenopolypeptide Genes and Selenocysteine Biosynthesis Machinery Genes in Escherichia coli during Selenite Reduction by Sun, Katherine H., Kittur, Farooqahmed S., Tetteh, Antonia Y., Xie, Jiahua, Williams, Daniel, Ibeanu, Gordon C., Hung, Chiu-Yueh

“…Bacteria can reduce toxic selenite into less toxic, elemental selenium (Se0), but the mechanism on how bacterial cells reduce selenite at molecular level is…”
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Immunoinformatics and Vaccine Development: An Overview by Oli, Angus Nnamdi, Obialor, Wilson Okechukwu, Ifeanyichukwu, Martins Ositadimma, Odimegwu, Damian Chukwu, Okoyeh, Jude Nnaemeka, Emechebe, George Ogonna, Adejumo, Samson Adedeji, Ibeanu, Gordon C

“…The use of vaccines have resulted in a remarkable improvement in global health. It has saved several lives, reduced treatment costs and raised the quality of…”
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A synthetic analog of verbenachalcone potentiates NGF-induced neurite outgrowth and enhances cell survival in neuronal cell models by Clement, Ceiléssia M., Dandepally, Srinivasa R., Williams, Alfred L., Ibeanu, Gordon C.

“…This study uses NeuroScreen-1 (NS-1) cells, a derivative of pheochromocytoma (PC12) cells, to examine neurite outgrowth induced by a novel synthetic…”
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The Chemical Molecule B355252 is Neuroprotective in an In Vitro Model of Parkinson’s Disease by Gliyazova, Nailya S., Ibeanu, Gordon C.

“…6-Hydroxydopamine (6-OHDA) is a neurotoxin frequently used to create in vitro and in vivo experimental models of Parkinson’s disease (PD), a chronic…”
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Gut microbiota alteration - Cancer relationships and synbiotic roles in cancer therapies by Rowaiye, Adekunle, Ibeanu, Gordon C., Bur, Doofan, Nnadi, Sandra, Mgbeke, Odinaka E., Morikwe, Ugonna

“…Cancer poses a significant global health challenge, with 10 million deaths and 19.3 million new cases reported annually. This review aims to investigate the…”
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Neuroprotective effects of an in vitro BBB permeable phenoxythiophene sulfonamide small molecule in glutamate‑induced oxidative injury by Pokharel, Smritee, Gliyazova, Nailya S, Dandepally, Srinivasa R, Williams, Alfred L, Ibeanu, Gordon C

“…Reactive oxygen species (ROS) play a central role in oxidative stress-associated neuronal cell death during ischemia. Further investigation into the inhibition…”
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Transcriptional Regulation of Human CYP2C Genes: Functional Comparison of CYP2C9 and CYP2C18 Promoter Regions by Ibeanu, Gordon C, Goldstein, Joyce A

“…The cytochrome P4502C subfamily comprises a group of constitutive microsomal hemoproteins which are expressed primarily in liver. In humans, this subfamily is…”
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A high throughput fluorescence polarization assay for inhibitors of the GoLoco motif/G-alpha interaction by Kimple, Adam J, Yasgar, Adam, Hughes, Mark, Jadhav, Ajit, Willard, Francis S, Muller, Robin E, Austin, Christopher P, Inglese, James, Ibeanu, Gordon C, Siderovski, David P, Simeonov, Anton

“…The GoLoco motif is a short Galpha-binding polypeptide sequence. It is often found in proteins that regulate cell-surface receptor signaling, such as RGS12, as…”
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Identification of Residues 99, 220, and 221 of Human Cytochrome P450 2C19 as Key Determinants of Omeprazole Hydroxylase Activity (∗) by Ibeanu, Gordon C., Ghanayem, Burhan I., Linko, Patricia, Li, Leiping, Pedersen, Lee G., Goldstein, Joyce A.

“…Human P450 2C19 is selective for 4′-hydroxylation of S-mephenytoin and 5-hydroxylation of omeprazole, while the structurally homologous P450 2C9 has low…”
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Identification of Residues 286 and 289 as Critical for Conferring Substrate Specificity of Human CYP2C9 for Diclofenac and Ibuprofen by Klose, Theresa S., Ibeanu, Gordon C., Ghanayem, Burhan I., Pedersen, Lee G., Li, Leiping, Hall, Stephen D., Goldstein, Joyce A.

“…Specificity of human CYP2C9 for two substrates, diclofenac and ibuprofen, was studied using chimeras and site-directed mutants of CYP2C9 and the highly related…”
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A rapid, inexpensive high throughput screen method for neurite outgrowth by Yeyeodu, Susan T, Witherspoon, Sam M, Gilyazova, Nailya, Ibeanu, Gordon C

“…Neurite outgrowth assays are the most common phenotypic screen to assess chemical effects on neuronal cells. Current automated assays involve expensive…”
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Assessment of Immunostimulating effect of Carica papaya-based Immunostimulatory Complexes Against Streptococcus pneumoniae Infections by Abel Briggs, Tamunotonye, Oli, Angus Nnamdi, Okoye, Ebere Innocent, Obajuluwa, Ayokunnumi Funke, Ezejiegu, Chinelo Kene, Ofomata, Chijioke Maxwell, Ibeanu, Gordon C.

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A novel transversion in the intron 5 donor splice junction of CYP2C19 and a sequence polymorphism in exon 3 contribute to the poor metabolizer phenotype for the anticonvulsant drug S-mephenytoin by Ibeanu, G C, Blaisdell, J, Ferguson, R J, Ghanayem, B I, Brosen, K, Benhamou, S, Bouchardy, C, Wilkinson, G R, Dayer, P, Goldstein, J A

“…Cytochrome P-450 (CYP) 2C19 is responsible for the metabolism of a number of therapeutic agents such as S-mephenytoin, omeprazole, proguanil, certain…”
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Identification of new human CYP2C19 alleles (CYP2C196 and CYP2C192B) in a Caucasian poor metabolizer of mephenytoin by Ibeanu, G C, Goldstein, J A, Meyer, U, Benhamou, S, Bouchardy, C, Dayer, P, Ghanayem, B I, Blaisdell, J

“…A genetic polymorphism in the metabolism of the anticonvulsant drug S-mephenytoin has been attributed to defective CYP2C19 alleles. This genetic polymorphism…”
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Cloning and expression in Escherichia coli of a human cDNA encoding the DNA repair protein N-methylpurine-DNA glycosylase by Chakravarti, D, Ibeanu, G C, Tano, K, Mitra, S

“…A 871-base pair cDNA encoding the human N-methylpurine-DNA glycosylase (MPG) was cloned from a HeLa S3 cDNA expression library in a pUC vector by phenotypic…”
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Structural organization of the mouse DNA repair gene, N-methylpurine-DNA glycosylase by Tatsuka, M, Ibeanu, G C, Izumi, T, Narayan, S, Ramana, C V, Kim, N K, Kang, W, Roy, G, Mitra, S

“…N-Methylpurine-DNA glycosylase (MPG), a ubiquitous DNA repair enzyme, removes N-alkylpurines and other purine lesions induced in DNA by simple alkylating…”
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