Search Results - "Ibeanu, G C"

Cloning and expression in Escherichia coli of a human cDNA encoding the DNA repair protein N-methylpurine-DNA glycosylase by Chakravarti, D, Ibeanu, G C, Tano, K, Mitra, S

“…A 871-base pair cDNA encoding the human N-methylpurine-DNA glycosylase (MPG) was cloned from a HeLa S3 cDNA expression library in a pUC vector by phenotypic…”
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A novel transversion in the intron 5 donor splice junction of CYP2C19 and a sequence polymorphism in exon 3 contribute to the poor metabolizer phenotype for the anticonvulsant drug S-mephenytoin by Ibeanu, G C, Blaisdell, J, Ferguson, R J, Ghanayem, B I, Brosen, K, Benhamou, S, Bouchardy, C, Wilkinson, G R, Dayer, P, Goldstein, J A

“…Cytochrome P-450 (CYP) 2C19 is responsible for the metabolism of a number of therapeutic agents such as S-mephenytoin, omeprazole, proguanil, certain…”
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Identification of new human CYP2C19 alleles (CYP2C196 and CYP2C192B) in a Caucasian poor metabolizer of mephenytoin by Ibeanu, G C, Goldstein, J A, Meyer, U, Benhamou, S, Bouchardy, C, Dayer, P, Ghanayem, B I, Blaisdell, J

“…A genetic polymorphism in the metabolism of the anticonvulsant drug S-mephenytoin has been attributed to defective CYP2C19 alleles. This genetic polymorphism…”
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Identification of Residues 99, 220, and 221 of Human Cytochrome P450 2C19 as Key Determinants of Omeprazole Hydroxylase Activity (∗) by Ibeanu, Gordon C., Ghanayem, Burhan I., Linko, Patricia, Li, Leiping, Pedersen, Lee G., Goldstein, Joyce A.

“…Human P450 2C19 is selective for 4′-hydroxylation of S-mephenytoin and 5-hydroxylation of omeprazole, while the structurally homologous P450 2C9 has low…”
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Identification of Residues 286 and 289 as Critical for Conferring Substrate Specificity of Human CYP2C9 for Diclofenac and Ibuprofen by Klose, Theresa S., Ibeanu, Gordon C., Ghanayem, Burhan I., Pedersen, Lee G., Li, Leiping, Hall, Stephen D., Goldstein, Joyce A.

“…Specificity of human CYP2C9 for two substrates, diclofenac and ibuprofen, was studied using chimeras and site-directed mutants of CYP2C9 and the highly related…”
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Transcriptional Regulation of Human CYP2C Genes: Functional Comparison of CYP2C9 and CYP2C18 Promoter Regions by Ibeanu, Gordon C, Goldstein, Joyce A

“…The cytochrome P4502C subfamily comprises a group of constitutive microsomal hemoproteins which are expressed primarily in liver. In humans, this subfamily is…”
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An additional defective allele, CYP2C195, contributes to the S-mephenytoin poor metabolizer phenotype in Caucasians by Ibeanu, G C, Blaisdell, J, Ghanayem, B I, Beyeler, C, Benhamou, S, Bouchardy, C, Wilkinson, G R, Dayer, P, Daly, A K, Goldstein, J A

“…The metabolism of the anticonvulsant drug mephenytoin exhibits a genetic polymorphism in humans. This polymorphism exhibits marked racial heterogeneity, with…”
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Immunoinformatics and Vaccine Development: An Overview by Oli, Angus Nnamdi, Obialor, Wilson Okechukwu, Ifeanyichukwu, Martins Ositadimma, Odimegwu, Damian Chukwu, Okoyeh, Jude Nnaemeka, Emechebe, George Ogonna, Adejumo, Samson Adedeji, Ibeanu, Gordon C

“…The use of vaccines have resulted in a remarkable improvement in global health. It has saved several lives, reduced treatment costs and raised the quality of…”
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Structural organization of the mouse DNA repair gene, N-methylpurine-DNA glycosylase by Tatsuka, M, Ibeanu, G C, Izumi, T, Narayan, S, Ramana, C V, Kim, N K, Kang, W, Roy, G, Mitra, S

“…N-Methylpurine-DNA glycosylase (MPG), a ubiquitous DNA repair enzyme, removes N-alkylpurines and other purine lesions induced in DNA by simple alkylating…”
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Molecular cloning of Clostridium difficile toxin A gene fragment in λ gtll by Muldrow, Lycurgus L., Ibeanu, Gordon C., Lee, Norveta I., Bose, Nripendra K., Johnson, Joe

“…Toxin A of Clostridium difficile has been purified and monospecific antiserum produced. A reliable procedure for isolation and restriction of C. difficile…”
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Identification of residues 99, 220, and 221 of human cytochrome P450 2C19 as key determinants of omeprazole activity by Ibeanu, G C, Ghanayem, B I, Linko, P, Li, L, Pederson, L G, Goldstein, J A

“…Human P450 2C19 is selective for 4'-hydroxylation of S-mephenytoin and 5-hydroxylation of omeprazole, while the structurally homologous P450 2C9 has low…”
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Molecular cloning of Clostridium difficile toxin A gene fragment in lambda gt11 by Muldrow, L L, Ibeanu, G C, Lee, N I, Bose, N K, Johnson, J

“…Toxin A of Clostridium difficile has been purified and monospecific antiserum produced. A reliable procedure for isolation and restriction of C. difficile…”
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