Search Results - "Ibbotson, R E"

Dysregulation of cyclin dependent kinase 6 expression in splenic marginal zone lymphoma through chromosome 7q translocations by CORCORAN, M. M, MOULD, S. J, ORCHARD, J. A, IBBOTSON, R. E, CHAPMAN, R. M, BORIGHT, A. P, PLATT, C, TSUI, L.-C, SCHERER, S. W, OSCIER, D. G

“…The increased or inappropriate expression of genes with oncogenic properties through specific chromosome translocations is an important event in the…”
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P2X7 polymorphism and chronic lymphocytic leukaemia: lack of correlation with incidence, survival and abnormalities of chromosome 12 by ZHANG, L. Y, IBBOTSON, R. E, ORCHARD, J. A, GARDINER, A. C, SEEAR, R. V, CHASE, A. J, OSCIER, D. G, CROSS, N. C. P

“…The P2X7 receptor, a plasma membrane ATP-gated ion channel that plays a role in lymphocyte apoptosis, has been suggested as an important contributory factor to…”
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A subset of Binet stage A CLL patients with TP53 abnormalities and mutated IGHV genes have stable disease by Best, O G, Gardiner, A C, Davis, Z A, Tracy, I, Ibbotson, R E, Majid, A, Dyer, M J S, Oscier, D G

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Novel technique to facilitate the rapid identification of CLL patients utilising the VH3-21 gene by Davis, Z A, Ibbotson, R E, Wiseman, C M, Oscier, D G

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Sequence Divergence and Copy Number of the Middle- and Long-Wave Photopigment Genes in Old World Monkeys by Ibbotson, Rachel E., Hunt, David M., Bowmaker, James. K., Mollon, John Dixon

“…We have studied the sequence and organization of the genes for the middle-wave (MW) and long-wave (LW) cone photopigment genes in six species of Old World…”
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ZAP‐70 by flow cytometry: A comparison of different antibodies, anticoagulants, and methods of analysis by Best, O. G., Ibbotson, R. E., Parker, A. E., Davis, Z. A., Orchard, J. A., Oscier, D. G.

“…Background: The clinical course of chronic lymphocytic leukaemia (CLL) is variable. ZAP‐70 expression is believed to provide prognostic information. The flow…”
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PCR analysis of polymorphisms at the D13S25 locus by Ibbotson, R E, Chapman, R M, Corcoran, M M, Oscier, D G

“…Evidence that the D13S25 locus lies close to a potential tumour suppressor gene implicated in the pathogenesis of B-CLL has been based on detection of LOH and…”
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Detailed molecular delineation of 13q14.3 loss in B-cell chronic lymphocytic leukemia by Corcoran, M M, Rasool, O, Liu, Y, Iyengar, A, Grander, D, Ibbotson, R E, Merup, M, Wu, X, Brodyansky, V, Gardiner, A C, Juliusson, G, Chapman, R M, Ivanova, G, Tiller, M, Gahrton, G, Yankovsky, N, Zabarovsky, E, Oscier, D G, Einhorn, S

“…A region of chromosome 13q14.3, telomeric to the Retinoblastoma gene RB-1 is frequently deleted in patients with B-cell chronic lymphocytic leukemia (B-CLL). A…”
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Methylation analysis by means of PCR SSCP: application to clonality studies by Corcoran, Martin M., Ibbotson, Rachel E., Lu, Wei Z., Chapman, Robert M., Oscier, David G.

“…We have developed a rapid procedure for determining the differing methylation status, on maternally and paternally derived alleles, of particular CpG…”
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ZAP-70 expression and prognosis in chronic lymphocytic leukaemia by Orchard, Jenny A, Ibbotson, Rachel E, Davis, Zadie, Wiestner, Adrian, Rosenwald, Andreas, Thomas, Peter W, Hamblin, Terry J, Staudt, Louis M, Oscier, David G

“…Chronic lymphocytic leukaemia (CLL) is a heterogeneous disease; many patients never need treatment, whereas some have poor outcomes. New treatments, which can…”
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ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile by Wiestner, Adrian, Rosenwald, Andreas, Barry, Todd S., Wright, George, Davis, R. Eric, Henrickson, Sarah E., Zhao, Hong, Ibbotson, Rachel E., Orchard, Jenny A., Davis, Zadie, Stetler-Stevenson, Maryalice, Raffeld, Mark, Arthur, Diane C., Marti, Gerald E., Wilson, Wyndham H., Hamblin, Terry J., Oscier, David G., Staudt, Louis M.

“…The presence or absence of somatic mutations in the expressed immunoglobulin heavy chain variable regions (IgVH) of chronic lymphocytic leukemia (CLL) cells…”
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CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease by Hamblin, Terry J., Orchard, Jenny A., Ibbotson, Rachel E., Davis, Zadie, Thomas, Peter W., Stevenson, Freda K., Oscier, David G.

“…Although the presence or absence of somatic mutations in the immunoglobulin variable region (IgVH) genes in chronic lymphocytic leukemia (B-CLL) identifies…”
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Multivariate analysis of prognostic factors in CLL: clinical stage, IGVH gene mutational status, and loss or mutation of the p53 gene are independent prognostic factors by Oscier, David G., Gardiner, Anne C., Mould, Sarah J., Glide, Sharron, Davis, Zadie A., Ibbotson, Rachel E., Corcoran, Martin M., Chapman, Robert M., Thomas, Peter W., Copplestone, J. Adrian, Orchard, Jenny A., Hamblin, Terry J.

“…This study evaluates the prognostic significance of genetic abnormalities (detected at or shortly after presentation), clinical stage, lymphocyte morphology,…”
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DLEU2 encodes an antisense RNA for the putative bicistronic RFP2/LEU5 gene in humans and mouse by Corcoran, Martin M., Hammarsund, Marianne, Zhu, Chaoyong, Lerner, Mikael, Kapanadze, Bagrat, Wilson, Bill, Larsson, Catharina, Forsberg, Lars, Ibbotson, Rachel E., Einhorn, Stefan, Oscier, David G., Grandér, Dan, Sangfelt, Olle

“…Our group previously identified two novel genes, RFP2/LEU5 and DLEU2, within a 13q14.3 genomic region of loss seen in various malignancies. However, no…”
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DLEU2, Located within the CLL 13q14 Deletion Locus, Encodes an Antisense RNA for the Putative Bicistronic RFP2/LEU5 Gene in Humans and Mouse by Corcoran, Martin M., Hammarsund, Marianne, Zhu, Chaoyong, Lerner, Mikael, Kapanadze, Bagrat, Larsson, Catharina, Forsberg, Lars, Ibbotson, Rachel E., Einhorn, Stefan, Oscier, David G., Grander, Dan, Sangfelt, Olle

“…Our group previously identified two novel genes, RFP2/LEU5 and DLEU2, within a 13q14.3 genomic region of loss seen in various malignancies, including chronic…”
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Detailed molecular delineation of 13q14.3 loss in B-cell chronic lymphocytic leukemia by CORCORAN, M. M, RASOOL, O, JULIUSSON, G, CHAPMAN, R. M, IVANOVA, G, TILER, M, GAHRTON, G, YANKOVSKY, N, ZABAROVSKY, E, OSCIER, D. G, EINHORN, S, YIE LIU, LYENGAR, A, GRANDER, D, IBBOTSON, R. E, MERUP, M, XIUSHAN WU, BRODYANSKY, V, GARDINER, A. C

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Characterisation of a candidate tumor suppressor gene LEU2B located at 13q14.3 in chronic lymphocytic leukemia by Corcoran, MM, Sangfelt, O, Kapanadze, B, Makeevaa, N, Ibbotson, RE, Baranova, A, Zabarovsky, E, Merup, M, Jansson, O, Gahrton, G, Einhorn, S, Grander, D, Oscier, DG

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