Search Results - "Ibarrola, Jaime"

Editorial: Heart valve diseases: from molecular mechanisms to clinical implications by Ibarrola, Jaime, Lopez-Andres, Natalia

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Galectin-3 Blockade Reduces Renal Fibrosis in Two Normotensive Experimental Models of Renal Damage by Martinez-Martinez, Ernesto, Ibarrola, Jaime, Calvier, Laurent, Fernandez-Celis, Amaya, Leroy, Celine, Cachofeiro, Victoria, Rossignol, Patrick, Lopez-Andres, Natalia

“…Galectin-3 (Gal-3), a β-galactoside-binding lectin, is increased in kidney injury and its pharmacological blockade reduces renal damage in acute kidney injury,…”
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Neutrophil Gelatinase-Associated Lipocalin From Macrophages Plays a Critical Role in Renal Fibrosis Via the CCL5 (Chemokine Ligand 5)-Th2 Cells-IL4 (Interleukin 4) Pathway by Bonnard, Benjamin, Ibarrola, Jaime, Lima-Posada, Ixchel, Fernández-Celis, Amaya, Durand, Manon, Genty, Marie, Lopez-Andrés, Natalia, Jaisser, Frédéric

“…NGAL (neutrophil gelatinase-associated lipocalin; or lipocalin 2, Lcn2) is a novel mineralocorticoid target in the cardiovascular system. We showed that Lcn2…”
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Myocardial Injury After Ischemia/Reperfusion Is Attenuated By Pharmacological Galectin-3 Inhibition by Ibarrola, Jaime, Matilla, Lara, Martínez-Martínez, Ernesto, Gueret, Alexandre, Fernández-Celis, Amaya, Henry, Jean-Paul, Nicol, Lionel, Jaisser, Frederic, Mulder, Paul, Ouvrard-Pascaud, Antoine, López-Andrés, Natalia

“…Although optimal therapy for myocardial infarction includes reperfusion to restore blood flow to the ischemic region, ischemia/reperfusion (IR) also initiates…”
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Galectin-3 down-regulates antioxidant peroxiredoxin-4 in human cardiac fibroblasts: a new pathway to induce cardiac damage by Ibarrola, Jaime, Arrieta, Vanessa, Sádaba, Rafael, Martinez-Martinez, Ernesto, Garcia-Peña, Amaia, Alvarez, Virginia, Fernández-Celis, Amaya, Gainza, Alicia, Santamaría, Enrique, Fernández-Irigoyen, Joaquin, Cachofeiro, Victoria, Zalba, Guillermo, Fay, Renaud, Rossignol, Patrick, López-Andrés, Natalia

“…Galectin-3 (Gal-3) is increased in heart failure (HF) and promotes cardiac fibrosis and inflammation. We investigated whether Gal-3 modulates oxidative stress…”
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Beneficial Effects of Mineralocorticoid Receptor Antagonism on Myocardial Fibrosis in an Experimental Model of the Myxomatous Degeneration of the Mitral Valve by Ibarrola, Jaime, Garaikoetxea, Mattie, Garcia-Peña, Amaia, Matilla, Lara, Jover, Eva, Bonnard, Benjamin, Cuesta, Maria, Fernández-Celis, Amaya, Jaisser, Frederic, López-Andrés, Natalia

“…Mitral valve prolapse (MVP) patients develop myocardial fibrosis that is not solely explained by volume overload, but the pathophysiology has not been defined…”
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Differential Proteomics Identifies Reticulocalbin-3 as a Novel Negative Mediator of Collagen Production in Human Cardiac Fibroblasts by Martínez-Martínez, Ernesto, Ibarrola, Jaime, Fernández-Celis, Amaya, Santamaria, Enrique, Fernández-Irigoyen, Joaquín, Rossignol, Patrick, Jaisser, Frederic, López-Andrés, Natalia

“…Cardiac fibrosis is characterized by an excessive accumulation of extracellular matrix components, including collagens. Galectin-3 (Gal-3) and Cardiotrophin-1…”
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Aldosterone Impairs Mitochondrial Function in Human Cardiac Fibroblasts via A-Kinase Anchor Protein 12 by Ibarrola, Jaime, Sadaba, Rafael, Martinez-Martinez, Ernesto, Garcia-Peña, Amaia, Arrieta, Vanessa, Alvarez, Virginia, Fernández-Celis, Amaya, Gainza, Alicia, Cachofeiro, Victoria, Santamaria, Enrique, Fernandez-Irigoyen, Joaquin, Jaisser, Frederic, Lopez-Andres, Natalia

“…Aldosterone (Aldo) contributes to mitochondrial dysfunction and cardiac oxidative stress. Using a proteomic approach, A-kinase anchor protein (AKAP)-12 has…”
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Role for Galectin‐3 in Calcific Aortic Valve Stenosis by Sádaba, J. Rafael, Martínez‐Martínez, Ernesto, Arrieta, Vanessa, Álvarez, Virginia, Fernández‐Celis, Amaya, Ibarrola, Jaime, Melero, Amaia, Rossignol, Patrick, Cachofeiro, Victoria, López‐Andrés, Natalia

“…Background Aortic stenosis (AS) is a chronic inflammatory disease, and calcification plays an important role in the progression of the disease. Galectin‐3…”
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Activation of the Interleukin-33/ST2 Pathway Exerts Deleterious Effects in Myxomatous Mitral Valve Disease by Garcia-Pena, Amaia, Ibarrola, Jaime, Navarro, Adela, Sadaba, Alba, Tiraplegui, Carolina, Garaikoetxea, Mattie, Arrieta, Vanessa, Matilla, Lara, Fernández-Celis, Amaya, Sadaba, Rafael, Alvarez, Virginia, Gainza, Alicia, Jover, Eva, López-Andrés, Natalia

“…Mitral valve disease (MVD) is a frequent cause of heart failure and death worldwide, but its etiopathogenesis is not fully understood. Interleukin (IL)-33…”
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Beneficial Effects of Galectin-3 Blockade in Vascular and Aortic Valve Alterations in an Experimental Pressure Overload Model by Ibarrola, Jaime, Martínez-Martínez, Ernesto, Sádaba, J Rafael, Arrieta, Vanessa, García-Peña, Amaia, Álvarez, Virginia, Fernández-Celis, Amaya, Gainza, Alicia, Rossignol, Patrick, Cachofeiro Ramos, Victoria, López-Andrés, Natalia

“…Galectin-3 (Gal-3) is involved in cardiovascular fibrosis and aortic valve (AV) calcification. We hypothesized that Gal-3 pharmacological inhibition with…”
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Differential proteomics reveals S100-A11 as a key factor in aldosterone-induced collagen expression in human cardiac fibroblasts by Martínez-Martínez, Ernesto, Ibarrola, Jaime, Lachén-Montes, Mercedes, Fernández-Celis, Amaya, Jaisser, Frederic, Santamaría, Enrique, Fernández-Irigoyen, Joaquín, López-Andrés, Natalia

“…Aldosterone (Aldo) could induce cardiac fibrosis, a hallmark of heart disease. Aldo direct effects on collagen production in cardiac fibroblasts remain…”
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The Mineralocorticoid Receptor in the Vasculature: Friend or Foe? by Ibarrola, Jaime, Jaffe, Iris Z

“…Originally described as the renal aldosterone receptor that regulates sodium homeostasis, it is now clear that mineralocorticoid receptors (MRs) are widely…”
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Mechanism by Which Inflammation and Oxidative Stress Induce Mineralocorticoid Receptor Gene Expression in Aging Vascular Smooth Muscle Cells by Ibarrola, Jaime, Lu, Qing, Zennaro, Maria-Christina, Jaffe, Iris Z.

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Biomarcadores para el diagnóstico de infecciones articulares periprotésicas: Biomarkers for the diagnosis of periprosthetic joint infections by Ibarrola, Jaime

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Biomarcadores para el diagnóstico de infecciones articulares periprotésicas by Jaime Ibarrola

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Abstract 1110: The Sex-specific Role Of The Mineralocorticoid Receptor In Smooth Muscle Cells In Obesity-associated Vascular Stiffness by Ibarrola, Jaime, Xiang, Rachel, Liu, Rui R, Lu, Qing, Jaffe, Iris Z

“…Abstract only Introduction: Obesity is associated with increased vascular stiffness which predicts risk for heart attack, stroke and cardiovascular (CV)…”
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Mineralocorticoid Receptor in Endothelial Cells Contributes to VEGF Receptor Inhibitor-Induced Vascular and Kidney Damage by Camarda, Nicholas D, Lu, Qing, Tesfu, Angelina F, Liu, Rui R, Ibarrola, Jaime, Jaffe, Iris Z

“…Abstract BACKGROUND Vascular endothelial growth factor receptor inhibitors (VEGFRis) improve cancer patient survival by inhibiting tumor angiogenesis. However,…”
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Mechanism by Which Inflammation and Oxidative Stress Induce Mineralocorticoid Receptor Gene Expression in Aging Vascular Smooth Muscle Cells by Ibarrola, Jaime, Lu, Qing, Zennaro, Maria-Christina, Jaffe, Iris Z.

“…Vascular MR (mineralocorticoid receptor) expression increases with age driving aging-associated vascular stiffness and hypertension. MR has two isoforms (1α…”
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Mineralocorticoid Receptors in Vascular Smooth Muscle: Blood Pressure and Beyond by Camarda, Nicholas D, Ibarrola, Jaime, Biwer, Lauren A, Jaffe, Iris Z

“…After half a century of evidence suggesting the existence of mineralocorticoid receptors (MR) in the vasculature, the advent of technology to specifically…”
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