Search Results - "Ibarra, José M"

Nucleobase and Ribose Modifications Control Immunostimulation by a MicroRNA-122-mimetic RNA by Peacock, Hayden, Fucini, Raymond V, Jayalath, Prasanna, Ibarra-Soza, José M, Haringsma, Henry J, Flanagan, W. Michael, Willingham, Aarron, Beal, Peter A

“…Immune stimulation is a significant hurdle in the development of effective and safe RNA interference therapeutics. Here, we address this problem in the context…”
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Base Modification Strategies to Modulate Immune Stimulation by an siRNA by Valenzuela, Rachel Anne P., Suter, Scott R., Ball-Jones, Alexi A., Ibarra-Soza, José M., Zheng, Yuxuan, Beal, Peter A.

“…Immune stimulation triggered by siRNAs is one of the major challenges in the development of safe RNAi‐based therapeutics. Within an immunostimulatory siRNA…”
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Short Interfering RNA Guide Strand Modifiers from Computational Screening by Onizuka, Kazumitsu, Harrison, Jason G, Ball-Jones, Alexi A, Ibarra-Soza, José M, Zheng, Yuxuan, Ly, Diana, Lam, Walter, Mac, Stephanie, Tantillo, Dean J, Beal, Peter A

“…Short interfering RNAs (siRNAs) are promising drug candidates for a wide range of targets including those previously considered “undruggable”. However,…”
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Waste dump erosional landform stability – a critical issue for mountain mining by Martín‐Moreno, Cristina, Martín Duque, José F., Nicolau Ibarra, José M., Muñoz‐Martín, Alfonso, Zapico, Ignacio

“…Mining is the largest producer of solid wastes which, when released to land or into waterways, can cause harmful environmental impacts. This is mostly due to…”
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Click Modification of RNA at Adenosine: Structure and Reactivity of 7‑Ethynyl- and 7‑Triazolyl-8-aza-7-deazaadenosine in RNA by Phelps, Kelly J, Ibarra-Soza, José M, Tran, Kiet, Fisher, Andrew J, Beal, Peter A

“…Ribonucleoside analogues bearing terminal alkynes, including 7-ethynyl-8-aza-7-deazaadenosine (7-EAA), are useful for RNA modification applications. However,…”
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Type 1 diabetes in the Spanish population: additional factors to class II HLA-DR3 and -DR4 by Urcelay, Elena, Santiago, José L, de la Calle, Hermenegildo, Martínez, Alfonso, Méndez, Julián, Ibarra, José M, Maluenda, Carlos, Fernández-Arquero, Miguel, de la Concha, Emilio G

“…The Major Histocompatibility Complex is the main genetic contributor to susceptibility to type 1 diabetes (T1D); genome-wide scans have consistently mapped…”
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7-Substituted 8-aza-7-deazaadenosines for modification of the siRNA major groove by Ibarra-Soza, José M, Morris, Alexi A, Jayalath, Prasanna, Peacock, Hayden, Conrad, Wayne E, Donald, Michael B, Kurth, Mark J, Beal, Peter A

“…Here we describe the synthesis of new 7-substituted 8-aza-7-deazaadenosine ribonucleoside phosphoramidites and their use in generating major groove-modified…”
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Meeting the challenge of genomic analysis: a collaboratively developed workshop for pangenomics and topological data analysis by Contreras-Peruyero, Haydeé, Guerrero-Flores, Shaday, Zirión-Martínez, Claudia, Mejía-Ponce, Paulina M, Navarro-Miranda, Marisol, Lovaco-Flores, J Abel, Ibarra-Rodríguez, José M, Pashkov, Anton, Licona-Cassani, Cuauhtémoc, Sélem-Mojica, Nelly

“…As genomics data analysis becomes increasingly intricate, researchers face the challenge of mastering various software tools. The rise of Pangenomics analysis,…”
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Endocarditis infecciosa sobre válvulas protésicas causada por Staphylococcus capitis: un nuevo caso by Domínguez Rodríguez, Alberto, García González, Martín J., Lara Padrón, Antonio, Laynez Cerdeña, Ignacio, Barragán Acea, Antonio, Miralles Ibarra, José M., Lacalzada Almeida, Juan, Bosa Ojeda, Francisco, Marrero Rodríguez, Francisco, de Armas Trujillo, Diego

“…Se presenta el caso de un paciente varón, portador de prótesis valvular aórtica y mitral con endocarditis infecciosa por Staphylococcus capitis, bacteria…”
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An 18-month vitreous fluorophotometric follow-up study in juvenile diabetics by Benitez del Castillo, J M, Castillo, A, Garcia Sanchez, J, Ruibal, J L, Reverte, F, Ibarra, J M

“…The authors assessed a fluorophotometry follow-up study of 18 months in 24 juvenile insulin-dependent diabetic patients with no retinopathy. The initial…”
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