Search Results - "Ibañez, Carlos E."

Intravenous administration of retroviral replicating vector, Toca 511, demonstrates therapeutic efficacy in orthotopic immune-competent mouse glioma model by Huang, Tiffany T, Parab, Shraddha, Burnett, Ryan, Diago, Oscar, Ostertag, Derek, Hofman, Florence M, Espinoza, Fernando Lopez, Martin, Bryan, Ibañez, Carlos E, Kasahara, Noriyuki, Gruber, Harry E, Pertschuk, Daniel, Jolly, Douglas J, Robbins, Joan M

“…Toca 511 (vocimagene amiretrorepvec), a nonlytic, amphotropic retroviral replicating vector (RRV), encodes and delivers a functionally optimized yeast cytosine…”
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Blockade of type I interferon (IFN) production by retroviral replicating vectors and reduced tumor cell responses to IFN likely contribute to tumor selectivity by Lin, Amy H, Burrascano, Cindy, Pettersson, Par L, Ibañez, Carlos E, Gruber, Harry E, Jolly, Douglas J

“…We developed a Moloney mouse leukemia virus (MLV)-based retroviral replicating vector (RRV), Toca 511, which has displayed tumor specificity in resected brain…”
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Toca 511 plus 5-fluorocytosine in combination with lomustine shows chemotoxic and immunotherapeutic activity with no additive toxicity in rodent glioblastoma models by Yagiz, Kader, Huang, Tiffany T, Lopez Espinoza, Fernando, Mendoza, Daniel, Ibañez, Carlos E, Gruber, Harry E, Jolly, Douglas J, Robbins, Joan M

“…Toca 511, a gamma retroviral replicating vector encoding cytosine deaminase, used in combination with 5-fluorocytosine (5-FC) kills tumor by local production…”
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Maintaining therapeutic activity in the operating room: compatibility of a gamma-retroviral replicating vector with clinical materials and biofluids by Burnett, Ryan, Ibañez, Carlos E, Pettersson, Pär L, Chen, Ching-I, Parab, Shraddha, Huang, Tiffany, Robbins, Joan, Bankiewicz, Krystof, Aghi, Manish, Logg, Christopher, Kasahara, Noriyuki, Pertschuk, Dan, Gruber, Harry E, Jolly, Douglas J

“…Toca 511 is a novel retroviral replicating vector, encoding a modified yeast cytosine deaminase, administered to recurrent high grade glioma patients in Phase…”
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Brain tumor eradication and prolonged survival from intratumoral conversion of 5-fluorocytosine to 5-fluorouracil using a nonlytic retroviral replicating vector by Ostertag, Derek, Amundson, Karin K, Lopez Espinoza, Fernando, Martin, Bryan, Buckley, Taylor, Galvão da Silva, Ana Paula, Lin, Amy H, Valenta, David T, Perez, Omar D, Ibañez, Carlos E, Chen, Ching-I, Pettersson, Pär L, Burnett, Ryan, Daublebsky, Veronika, Hlavaty, Juraj, Gunzburg, Walter, Kasahara, Noriyuki, Gruber, Harry E, Jolly, Douglas J, Robbins, Joan M

“…Patients with the most common and aggressive form of high-grade glioma, glioblastoma multiforme, have poor prognosis and few treatment options. In 2…”
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Retroviral Replicating Vectors Deliver Cytosine Deaminase Leading to Targeted 5-Fluorouracil-Mediated Cytotoxicity in Multiple Human Cancer Types by Twitty, Chris G, Diago, Oscar R, Hogan, Daniel J, Burrascano, Cindy, Ibanez, Carlos E, Jolly, Douglas J, Ostertag, Derek

“…Toca 511 is a modified retroviral replicating vector based on Moloney γ-retrovirus with an amphotropic envelope. As an investigational cancer treatment, Toca…”
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A Retroviral Replicating Vector Encoding Cytosine Deaminase and 5-FC Induces Immune Memory in Metastatic Colorectal Cancer Models by Yagiz, Kader, Rodriguez-Aguirre, Maria E., Lopez Espinoza, Fernando, Montellano, Tiffany T., Mendoza, Daniel, Mitchell, Leah A., Ibanez, Carlos E., Kasahara, Noriyuki, Gruber, Harry E., Jolly, Douglas J., Robbins, Joan M.

“…Treatment of tumors with Toca 511, a gamma retroviral replicating vector encoding cytosine deaminase, followed by 5-fluorocytosine (5-FC) kills tumors by local…”
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Generation of Retroviral Packaging and Producer Cell Lines for Large-Scale Vector Production and Clinical Application: Improved Safety and High Titer by Sheridan, Philip L., Bodner, Mordechai, Lynn, Andrea, Phuong, Trung K., DePolo, Nicholas J., de la Vega, Daniel J., O'Dea, Joanne, Nguyen, Kathy, McCormack, James E., Driver, David A., Townsend, Kay, Ibañez, Carlos E., Sajjadi, Nancy C., Greengard, Judith S., Moore, Margaret D., Respess, James, Chang, Stephen M.W., Dubensky, Thomas W., Jolly, Douglas J., Sauter, Sybille L.

“…For many applications, human clinical therapies using retroviral vectors still require many technological improvements in key areas of vector design and…”
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The use and development of retroviral vectors to deliver cytokine genes for cancer therapy by Fong, T C, Sauter, S L, Ibañez, C E, Sheridan, P L, Jolly, D J

“…In this review, we describe technical advancements of retroviral vectors to address issues of safety, titer, and clinical scale manufacturing to produce…”
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205. Cytotoxic and Immunotherapeutic Effects of Toca 511 and 5-Fluorocytosine in an Intraperitoneal Model of Metastatic Colorectal Cancer by Yagiz, Kader, Mendoza, Daniel, Rodriguez-Aguirre, Maria, Espinoza, Fernando Lopez, Ibañez, Carlos E., Gruber, Harry E., Jolly, Douglas J., Robbins, Joan M.

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Caries in patients with cleft lip and palate, and their dental rehabilitation. Presentation of a clinical case by Ibáñez, Carlos E. Varela, Viveros, Diana Rivero, Navarrete, Margarita Ibarra

“…During the first three months of pregnancy, the parts of the palate and upper lip normally meet. When this union does not occur, the baby will present cleft…”
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227. Cancer Cell Susceptibility To Treatment With a Retroviral Replicating Vector Encoding Cytosine Deaminase and 5-FC Is Likely To Be Common by Twitty, Chris G., Diago, Oscar R., Hogan, Daniel, Burrascano, Cindy, Ibanez, Carlos E., Jolly, Douglas J., Ostertag, Derek

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Additive therapeutic effect of a non-lytic retroviral replicating vector (Toca 511) and 5-fluorocytosine in combination with lomustine in experimental glioma models by Robbins, Joan M., Huang, Tiffany T., Yagiz, Kader, Lopez Espinoza, Fernando, Martin, Bryan, Rodriguez-Aguirre, Maria, Ibanez, Carlos E., Gruber, Harry E., Jolly, Douglas J.

“…Abstract only…”
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Abstract 708: Toca 511 gene therapy in combination with 5-fluorocytosine for intratumoral production of 5-fluorouracil in a colon cancer metastasis model by Rodriguez-Aguirre, Maria E., Espinoza, Fernando Lopez, Martin, Bryan, Yadiz, Kader, Huang, Tiffany T., Ibanez, Carlos E., Ostertag, Derek G., Kasahara, Noriyuki, Gruber, Harry E., Jolly, Douglas J., Robbins, Joan M.

“…Despite advances in screening, colorectal cancer (CRC) remains the fourth most commonly diagnosed cancer and the second leading cause of cancer death for both…”
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Convection-enhanced delivery improves distribution and efficacy of tumor-selective retroviral replicating vectors in a rodent brain tumor model by Yin, D, Zhai, Y, Gruber, H E, Ibanez, C E, Robbins, J M, Kells, A P, Kasahara, N, Forsayeth, J, Jolly, D J, Bankiewicz, K S

“…In the present study, we compared the therapeutic effect of tumor-selective retroviral replicating vectors (RRV) expressing the yeast cytosine deaminase (CD)…”
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Ascending dose trials of the safety and tolerability of Toca 511, a retroviral replicating vector encoding cytosine deaminase, in patients with recurrent high-grade glioma by Pertschuk, Daniel, Cloughesy, Timothy Francis, Chang, Susan Marina, Aghi, Manish K., Vogelbaum, Michael A., Liau, Linda M., Shafa, Bob B., Yong, William H., Chen, Clark, Kesari, Santosh, Ibanez, Carlos E., Perez, Omar D., Robbins, Joan M., Jolly, Douglas J., Gruber, Harry E.

“…Abstract only 2101 Background: Patients with the most common and aggressive form of brain cancer, glioblastoma multiforme (GBM), have a poor prognosis and…”
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Human cytomegalovirus productively infects primary differentiated macrophages by IBANEZ, C. E, SCHRIER, R, GHAZAL, P, WILEY, C, NELSON, J. A

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Sindbis virus DNA-based expression vectors: utility for in vitro and in vivo gene transfer by Dubensky, Jr, T W, Driver, D A, Polo, J M, Belli, B A, Latham, E M, Ibanez, C E, Chada, S, Brumm, D, Banks, T A, Mento, S J, Jolly, D J, Chang, S M

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trans activation of gene expression by v-myb by IBANEZ, C. E, LIPSICK, J. S

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trans Activation of Gene Expression by v-myb by Ibanez, Carlos E., Lipsick, Joseph S.

“…The v-myb oncogene causes acute myelomonocytic leukemia in chickens and transforms avian myeloid cells in vitro. Its product, p48 v- myb , is a short-lived…”
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