Search Results - "Iannuzzi, Clara"

Understanding the Role of Protein Glycation in the Amyloid Aggregation Process by Sirangelo, Ivana, Iannuzzi, Clara

“…Protein function and flexibility is directly related to the native distribution of its structural elements and any alteration in protein architecture leads to…”
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The Role of Metal Binding in the Amyotrophic Lateral Sclerosis-Related Aggregation of Copper-Zinc Superoxide Dismutase by Sirangelo, Ivana, Iannuzzi, Clara

“…Protein misfolding and conformational changes are common hallmarks in many neurodegenerative diseases involving formation and deposition of toxic protein…”
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Overview of the Role of Vanillin in Neurodegenerative Diseases and Neuropathophysiological Conditions by Iannuzzi, Clara, Liccardo, Maria, Sirangelo, Ivana

“…Nowadays, bioactive natural products play key roles in drug development due to their safety profile and strong antioxidant power. Vanillin is a natural…”
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The effect of glycosaminoglycans (GAGs) on amyloid aggregation and toxicity by Iannuzzi, Clara, Irace, Gaetano, Sirangelo, Ivana

“…Amyloidosis is a protein folding disorder in which normally soluble proteins are deposited extracellularly as insoluble fibrils, impairing tissue structure and…”
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Hydroxytyrosol Inhibits Protein Oligomerization and Amyloid Aggregation in Human Insulin by Sirangelo, Ivana, Borriello, Margherita, Vilasi, Silvia, Iannuzzi, Clara

“…Hydroxytyrosol (HT), one of the main phenolic components of olive oil, has attracted considerable interest for its biological properties, including a…”
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Insights into Insulin Fibril Assembly at Physiological and Acidic pH and Related Amyloid Intrinsic Fluorescence by Iannuzzi, Clara, Borriello, Margherita, Portaccio, Marianna, Irace, Gaetano, Sirangelo, Ivana

“…Human insulin is a widely used model protein for the study of amyloid formation as both associated to insulin injection amyloidosis in type II diabetes and…”
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Genistein Prevents Apoptosis and Oxidative Stress Induced by Methylglyoxal in Endothelial Cells by Liccardo, Maria, Sapio, Luigi, Perrella, Shana, Sirangelo, Ivana, Iannuzzi, Clara

“…Glycolytic overload promotes accumulation of the highly reactive dicarbonyl compounds, resulting in harmful conditions called dicarbonyl stress. Methylglyoxal…”
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Bacterial frataxin CyaY is the gatekeeper of iron-sulfur cluster formation catalyzed by IscS by Pastore, Annalisa, Adinolfi, Salvatore, Iannuzzi, Clara, Prischi, Filippo, Pastore, Chiara, Iametti, Stefania, Martin, Stephen R, Bonomi, Franco

“…Frataxin is a conserved protein involved in the cellular assembly of iron-sulfur clusters, but its exact role is not clear. Now work on bacterial frataxin CyaY…”
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Vanillin Prevents Doxorubicin-Induced Apoptosis and Oxidative Stress in Rat H9c2 Cardiomyocytes by Sirangelo, Ivana, Sapio, Luigi, Ragone, Angela, Naviglio, Silvio, Iannuzzi, Clara, Barone, Daniela, Giordano, Antonio, Borriello, Margherita

“…Doxorubicin (doxo) is an effective anticancer compound in several tumor types. However, as a consequence of oxidative stress induction and ROS overproduction,…”
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Glycation accelerates fibrillization of the amyloidogenic W7FW14F apomyoglobin by Iannuzzi, Clara, Maritato, Rosa, Irace, Gaetano, Sirangelo, Ivana

“…Neurodegenerative diseases are associated with misfolding and deposition of specific proteins, either intra or extracellularly in the nervous system. Advanced…”
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The role of zinc in the stability of the marginally stable IscU scaffold protein by Iannuzzi, Clara, Adrover, Miquel, Puglisi, Rita, Yan, Robert, Temussi, Piero Andrea, Pastore, Annalisa

“…Understanding the factors that determine protein stability is interesting because it directly reflects the evolutionary pressure coming from function and…”
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Hydroxytyrosol Prevents Doxorubicin-Induced Oxidative Stress and Apoptosis in Cardiomyocytes by Sirangelo, Ivana, Liccardo, Maria, Iannuzzi, Clara

“…Doxorubicin (Dox) is a highly effective chemotherapeutic agent employed in the handling of hematological and solid tumors. The effective use of Dox in cancer…”
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Dietary Advanced Glycation End Products (AGEs) and Urinary Fluorescent AGEs in Children and Adolescents: Findings from the Italian I.Family Project by Dello Russo, Marika, Sirangelo, Ivana, Lauria, Fabio, Formisano, Annarita, Iannuzzi, Clara, Hebestreit, Antje, Pala, Valeria, Siani, Alfonso, Russo, Paola

“…Advanced glycation end products (AGEs) have been implicated in chronic diseases in adults, but their role in paediatric populations remains uncertain. This…”
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Pinocembrin Protects from AGE-Induced Cytotoxicity and Inhibits Non-Enzymatic Glycation in Human Insulin by Borriello, Margherita, Iannuzzi, Clara, Sirangelo, Ivana

“…Advanced glycation end products (AGEs) are the end products of the glycation reaction and have a great importance in clinical science for their association…”
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Differential effects of glycation on protein aggregation and amyloid formation by Iannuzzi, Clara, Irace, Gaetano, Sirangelo, Ivana

“…Amyloids are a class of insoluble proteinaceous substances generally composed of linear un-branched fibrils that are formed from misfolded proteins…”
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Pooling strategy and chromosome painting characterize a living zebroid for the first time by Iannuzzi, Alessandra, Pereira, Jorge, Iannuzzi, Clara, Fu, Beiyuan, Ferguson-Smith, Malcolm

“…We have investigated the complex karyotype of a living zebra-donkey hybrid for the first time using chromosome-specific painting probes produced from…”
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D-ribose-glycation of insulin prevents amyloid aggregation and produces cytotoxic adducts by Iannuzzi, Clara, Borriello, Margherita, Carafa, Vincenzo, Altucci, Lucia, Vitiello, Milena, Balestrieri, Maria Luisa, Ricci, Giulia, Irace, Gaetano, Sirangelo, Ivana

“…Insulin is a key hormone regulating glucose homeostasis, intimately associated with glycemia and is exposed to glycation by glucose, reducing sugars and other…”
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Misfolding and amyloid aggregation of apomyoglobin by Iannuzzi, Clara, Maritato, Rosa, Irace, Gaetano, Sirangelo, Ivana

“…Apomyoglobin is an excellent example of a monomeric all α-helical globular protein whose folding pathway has been extensively studied and well characterized…”
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Anatomy of an iron-sulfur cluster scaffold protein: Understanding the determinants of [2Fe–2S] cluster stability on IscU by Adrover, Miquel, Howes, Barry D., Iannuzzi, Clara, Smulevich, Giulietta, Pastore, Annalisa

“…Protein-bound iron sulfur clusters are prosthetic groups involved in several metabolic pathways. Understanding how they interact with the host protein and…”
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Hydroxytyrosol Selectively Affects Non-Enzymatic Glycation in Human Insulin and Protects by AGEs Cytotoxicity by Sirangelo, Ivana, Borriello, Margherita, Liccardo, Maria, Scafuro, Marika, Russo, Paola, Iannuzzi, Clara

“…Hydroxytyrosol (HT), the major phenolic compound in olive oil, is attracting increasing interest for its beneficial properties including a notable antioxidant…”
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