Search Results - "Ian J. Davis"

Dual Chromatin and Cytoskeletal Remodeling by SETD2 by Park, In Young, Powell, Reid T., Tripathi, Durga Nand, Dere, Ruhee, Ho, Thai H., Blasius, T. Lynne, Chiang, Yun-Chen, Davis, Ian J., Fahey, Catherine C., Hacker, Kathryn E., Verhey, Kristen J., Bedford, Mark T., Jonasch, Eric, Rathmell, W. Kimryn, Walker, Cheryl Lyn

“…Posttranslational modifications (PTMs) of tubulin specify microtubules for specialized cellular functions and comprise what is termed a “tubulin code.” PTMs of…”
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Co-targeting JAK1/STAT6/GAS6/TAM signaling improves chemotherapy efficacy in Ewing sarcoma by Yu, Le, Deng, Yu, Wang, Xiaodong, Santos, Charlene, Davis, Ian J., Earp, H. Shelton, Liu, Pengda

“…Ewing sarcoma is a pediatric bone and soft tissue tumor treated with chemotherapy, radiation, and surgery. Despite intensive multimodality therapy, ~50%…”
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HDAC inhibition results in widespread alteration of the histone acetylation landscape and BRD4 targeting to gene bodies by Slaughter, Mariesa J., Shanle, Erin K., Khan, Abid, Chua, Katrin F., Hong, Tao, Boxer, Lisa D., Allis, C. David, Josefowicz, Steven Z., Garcia, Benjamin A., Rothbart, Scott B., Strahl, Brian D., Davis, Ian J.

“…Histone acetylation levels are regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs) that antagonistically control the overall…”
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BRG1/SMARCA4 inactivation promotes non-small cell lung cancer aggressiveness by altering chromatin organization by Orvis, Tess, Hepperla, Austin, Walter, Vonn, Song, Shujie, Simon, Jeremy, Parker, Joel, Wilkerson, Matthew D, Desai, Nisarg, Major, Michael B, Hayes, D Neil, Davis, Ian J, Weissman, Bernard

“…SWI/SNF chromatin remodeling complexes regulate critical cellular processes, including cell-cycle control, programmed cell death, differentiation, genomic…”
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The Cardiac TBX5 Interactome Reveals a Chromatin Remodeling Network Essential for Cardiac Septation by Waldron, Lauren, Steimle, Jeffrey D., Greco, Todd M., Gomez, Nicholas C., Dorr, Kerry M., Kweon, Junghun, Temple, Brenda, Yang, Xinan Holly, Wilczewski, Caralynn M., Davis, Ian J., Cristea, Ileana M., Moskowitz, Ivan P., Conlon, Frank L.

“…Human mutations in the cardiac transcription factor gene TBX5 cause congenital heart disease (CHD), although the underlying mechanism is unknown. We report…”
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A cross-sectional survey of bacterial species in plaque from client owned dogs with healthy gingiva, gingivitis or mild periodontitis by Davis, Ian J, Wallis, Corrin, Deusch, Oliver, Colyer, Alison, Milella, Lisa, Loman, Nick, Harris, Stephen

“…Periodontal disease is the most widespread oral disease in dogs which if left untreated results in significant pain to the pet and loss of dentition. The…”
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A Pyrosequencing Investigation of Differences in the Feline Subgingival Microbiota in Health, Gingivitis and Mild Periodontitis by Harris, Stephen, Croft, Julie, O'Flynn, Ciaran, Deusch, Oliver, Colyer, Alison, Allsopp, Judi, Milella, Lisa, Davis, Ian J

“…Periodontitis is the most frequently diagnosed health problem in cats yet little is known about the bacterial species important for the disease. The objective…”
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The canine oral microbiome by Dewhirst, Floyd E, Klein, Erin A, Thompson, Emily C, Blanton, Jessica M, Chen, Tsute, Milella, Lisa, Buckley, Catherine M F, Davis, Ian J, Bennett, Marie-Lousie, Marshall-Jones, Zoe V

“…Determining the bacterial composition of the canine oral microbiome is of interest for two primary reasons. First, while the human oral microbiome has been…”
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Type II innate lymphoid cell plasticity contributes to impaired reconstitution after allogeneic hematopoietic stem cell transplantation by Laurie, Sonia J., Foster, Joseph P., Bruce, Danny W., Bommiasamy, Hemamalini, Kolupaev, Oleg V., Yazdimamaghani, Mostafa, Pattenden, Samantha G., Chao, Nelson J., Sarantopoulos, Stefanie, Parker, Joel S., Davis, Ian J., Serody, Jonathan S.

“…Type II innate lymphoid cells (ILC2s) maintain homeostasis and barrier integrity in mucosal tissues. In both mice and humans, ILC2s poorly reconstitute after…”
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Targeting disialoganglioside GD2 with chimeric antigen receptor-redirected T cells in lung cancer by Reppel, Loïc, Tsahouridis, Ourania, Akulian, Jason, Davis, Ian J, Lee, Hong, Fucà, Giovanni, Weiss, Jared, Dotti, Gianpietro, Pecot, Chad V, Savoldo, Barbara

“…BackgroundWe explored whether the disialoganglioside GD2 (GD2) is expressed in small cell lung cancer (SCLC) and non-SCLC (NSCLC) and can be targeted by…”
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H3K36 Methylation Regulates Nutrient Stress Response in Saccharomyces cerevisiae by Enforcing Transcriptional Fidelity by McDaniel, Stephen L., Hepperla, Austin J., Huang, Jie, Dronamraju, Raghuvar, Adams, Alexander T., Kulkarni, Vidyadhar G., Davis, Ian J., Strahl, Brian D.

“…Set2-mediated histone methylation at H3K36 regulates diverse activities, including DNA repair, mRNA splicing, and suppression of inappropriate (cryptic)…”
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Widespread Chromatin Accessibility at Repetitive Elements Links Stem Cells with Human Cancer by Gomez, Nicholas C., Hepperla, Austin J., Dumitru, Raluca, Simon, Jeremy M., Fang, Fang, Davis, Ian J.

“…Chromatin regulation is critical for differentiation and disease. However, features linking the chromatin environment of stem cells with disease remain largely…”
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TFE3 fusions activate MET signaling by transcriptional up-regulation, defining another class of tumors as candidates for therapeutic MET inhibition by TSUDA, Masumi, DAVIS, Ian J, ARGANI, Pedram, SHUKIA, Neerav, MCGILL, Gael G, NAGAI, Makoto, SAITO, Tsuyoshi, LAE, Marick, FISHER, David E, LADANYI, Marc

“…Specific chromosomal translocations encoding chimeric transcription factors are considered to play crucial oncogenic roles in a variety of human cancers but…”
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An optogenetic switch for the Set2 methyltransferase provides evidence for transcription-dependent and -independent dynamics of H3K36 methylation by Lerner, Andrew M, Hepperla, Austin J, Keele, Gregory R, Meriesh, Hashem A, Yumerefendi, Hayretin, Restrepo, David, Zimmerman, Seth, Bear, James E, Kuhlman, Brian, Davis, Ian J, Strahl, Brian D

“…Histone H3 lysine 36 methylation (H3K36me) is a conserved histone modification associated with transcription and DNA repair. Although the effects of H3K36…”
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Tumor-specific retargeting of an oncogenic transcription factor chimera results in dysregulation of chromatin and transcription by Patel, Mukund, Simon, Jeremy M, Iglesia, Michael D, Wu, Sam B, McFadden, Andrew W, Lieb, Jason D, Davis, Ian J

“…Chromosomal translocations involving transcription factor genes have been identified in an increasingly wide range of cancers. Some translocations can create a…”
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SETD2 Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma by Chiang, Yun-Chen, Park, In-Young, Terzo, Esteban A, Tripathi, Durga Nand, Mason, Frank M, Fahey, Catherine C, Karki, Menuka, Shuster, Charles B, Sohn, Bo-Hwa, Chowdhury, Pratim, Powell, Reid T, Ohi, Ryoma, Tsai, Yihsuan S, de Cubas, Aguirre A, Khan, Abid, Davis, Ian J, Strahl, Brian D, Parker, Joel S, Dere, Ruhee, Walker, Cheryl L, Rathmell, W Kimryn

“…Loss of the short arm of chromosome 3 (3p) occurs early in >95% of clear cell renal cell carcinoma (ccRCC). Nearly ubiquitous 3p loss in ccRCC suggests…”
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State of the science: an update on renal cell carcinoma by Jonasch, Eric, Futreal, P Andrew, Davis, Ian J, Bailey, Sean T, Kim, William Y, Brugarolas, James, Giaccia, Amato J, Kurban, Ghada, Pause, Armin, Frydman, Judith, Zurita, Amado J, Rini, Brian I, Sharma, Pam, Atkins, Michael B, Walker, Cheryl L, Rathmell, W Kimryn

“…Renal cell carcinomas (RCC) are emerging as a complex set of diseases that are having a major socioeconomic impact and showing a continued rise in incidence…”
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Regulation of Neurotoxin Production and Sporulation by a Putative agrBD Signaling System in Proteolytic Clostridium botulinum by Cooksley, Clare M, Davis, Ian J, Winzer, Klaus, Chan, Weng C, Peck, Michael W, Minton, Nigel P

“…A significant number of genome sequences of Clostridium botulinum and related species have now been determined. In silico analysis of these data revealed the…”
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SPOP and OTUD7A Control EWS–FLI1 Protein Stability to Govern Ewing Sarcoma Growth by Su, Siyuan, Chen, Jianfeng, Jiang, Yao, Wang, Ying, Vital, Tamara, Zhang, Jiaming, Laggner, Christian, Nguyen, Kong T., Zhu, Zhichuan, Prevatte, Alex W., Barker, Natalie K., Herring, Laura E., Davis, Ian J., Liu, Pengda

“…Chromosomal translocation results in development of an Ewing sarcoma breakpoint region 1‐Friend leukemia integration 1 (EWS–FLI1) fusion oncogene in the…”
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Identification of the Receptor Tyrosine Kinase c-Met and Its Ligand, Hepatocyte Growth Factor, as Therapeutic Targets in Clear Cell Sarcoma by DAVIS, Ian J, MCFADDEN, Andrew W, YIXIANG ZHANG, COXON, Angela, BURGESS, Teresa L, WAGNER, Andrew J, FISHER, David E

“…Clear cell sarcoma (CCS), a childhood tumor of the tendons and aponeuroses, is uniformly fatal once it has metastasized because of its profound therapeutic…”
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