Search Results - "Ian F. C. Mc Kenzie"
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Multi-transgenic pigs expressing three fluorescent proteins produced with high efficiency by sperm mediated gene transfer
Published in Molecular reproduction and development (01-09-2005)“…Multi‐gene transgenic pigs would be of benefit for large animal models in medical, agricultural, and pharmaceutical applications; in particular for…”
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A Glycopeptide in Complex with MHC Class I Uses the GalNAc Residue as an Anchor
Published in Proceedings of the National Academy of Sciences - PNAS (09-12-2003)“…Peptides bind MHC class I molecules by anchoring hydrophobic side chains into pockets in the peptide binding groove. Here, we report an immunogenic (in vitro…”
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Anti-Pig IgM Antibodies in Human Serum React Predominantly with Gal(α1-3)Gal Epitopes
Published in Proceedings of the National Academy of Sciences - PNAS (01-12-1993)“…A major problem with pig-to-human-tissue xenograft studies is that humans have natural antibodies to pig cells; these antibodies would cause hyperacute…”
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Combined Transgenic Expression of α -galactosidase and α 1,2-fucosyltransferase Leads to Optimal Reduction in the Major Xenoepitope Galα (1,3)Gal
Published in Proceedings of the National Academy of Sciences - PNAS (23-12-1997)“…Hyperacute rejection of pig organs by humans involves the interaction of Galα (1,3)Gal with antibodies and complement. Strategies to reduce the amount of…”
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George D. Snell, 19 December 1903. 6 June 1996
Published in Proceedings of the American Philosophical Society (01-09-2001)Get full text
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Molecular Cloning of a Human Immunoglobulin G Fc Receptor
Published in Proceedings of the National Academy of Sciences - PNAS (01-04-1988)“…Human IgG Fc receptor (Fcγ R) cDNA clones were isolated by cross-species hybridization by probing cDNA libraries with the low-affinity Fcγ R β 1 cDNA clone…”
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The Murine Fc Receptor for Immunoglobulin: Purification, Partial Amino Acid Sequence, and Isolation of cDNA Clones
Published in Proceedings of the National Academy of Sciences - PNAS (01-09-1986)“…The murine Fc receptor for IgG (Fcγ R) was purified to homogeneity by immunoaffinity chromatography from detergent lysates of the macrophage cell line J774…”
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A Genomic Clone Encoding the α Chain of the OKM1, LFA-1, and Platelet Glycoprotein IIb--IIIa Molecules
Published in Proceedings of the National Academy of Sciences - PNAS (01-02-1986)“…LFA-1, an antigen involved in cytolytic T lymphocyte-mediated killing, and Mac-1, the receptor for complement component C3bi, constitute a family of…”
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Molecular Characterization of the Murine Cytotoxic T-Cell Membrane Glycoprotein Ly-3 (CD8)
Published in Proceedings of the National Academy of Sciences - PNAS (01-10-1987)“…The murine Ly-2/3 glycoprotein is a surface marker of T cells restricted by class I major histocompatibility complex antigens. It is a disulfide-bonded…”
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The Ly-15 Alloantigenic System: A Genetically Determined Polymorphism of the Murine Lymphocyte Function-Associated Antigen-1 Molecule
Published in Proceedings of the National Academy of Sciences - PNAS (01-01-1985)“…Serological and biochemical studies using monoclonal antibodies have demonstrated that the Ly-15 cell membrane alloantigens are polymorphic sites on the…”
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Ly-4, a New Locus Determining a Lymphocyte Cell-Surface Alloantigen in Mice
Published in Proceedings of the National Academy of Sciences - PNAS (01-04-1973)“…A new locus is described that determines an alloantigen on the surface of lymphocytes. It differs from loci previously described in that the corresponding…”
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