An immuno-epidemiological model for transient immune protection: A case study for viral respiratory infections
The dynamics of infectious disease in a population critically involves both within-host pathogen replication and between host pathogen transmission. While modeling efforts have recently explored how within-host dynamics contribute to shaping population transmission, fewer have explored how ongoing c...
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| Published in: | Infectious disease modelling Vol. 8; no. 3; pp. 855 - 864 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
China
Elsevier B.V
01-09-2023
KeAi Publishing KeAi Communications Co., Ltd |
| Subjects: | |
| Online Access: | Get full text |
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| Summary: | The dynamics of infectious disease in a population critically involves both within-host pathogen replication and between host pathogen transmission. While modeling efforts have recently explored how within-host dynamics contribute to shaping population transmission, fewer have explored how ongoing circulation of an epidemic infectious disease can impact within-host immunological dynamics. We present a simple, influenza-inspired model that explores the potential for re-exposure during a single, ongoing outbreak to shape individual immune response and epidemiological potential in non-trivial ways. We show how even a simplified system can exhibit complex ongoing dynamics and sensitive thresholds in behavior. We also find epidemiological stochasticity likely plays a critical role in reinfection or in the maintenance of individual immunological protection over time. |
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| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 2468-0427 2468-2152 2468-0427 |
| DOI: | 10.1016/j.idm.2023.07.004 |