The role of genetic polymorphisms of interleukins in chronic lymphocytic leukemia in patients of different ages

The role of genetic polymorphisms of interleukins in chronic lymphocytic leukemia in patients of different ages

Chronic lymphocytic leukemia (CLL) is a multifactorial disease, in which development the important role played the cytokine genes, in particular interleukins. This type of leukemia is more common in the elderly. The purpose of the study was to evaluate the association of genetic polymorphisms of int...

Full description

Saved in:
Bibliographic Details
Published in:Advances in gerontology = Uspekhi gerontologii Vol. 27; no. 3; p. 407
Main Authors: Sirotina, S S, Tikunova, T S, Proshchaev, K I, Efremova, O A, Batlutskaia, I V, Iakunchenko, T I, Sobianin, F I, Churnosov, M I, Alekseev, S M
Format: Journal Article
Language:Russian
Published: Russia (Federation) 2014
Subjects:
Adult
Aged
Aged, 80 and over
Case-Control Studies
Female
Gene Frequency
Humans
Interleukin 1 Receptor Antagonist Protein - genetics
Interleukin-1alpha - genetics
Interleukin-4 - genetics
Leukemia, Lymphocytic, Chronic, B-Cell - complications
Leukemia, Lymphocytic, Chronic, B-Cell - genetics
Male
Middle Aged
Minisatellite Repeats
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide
Risk Factors
Thrombocytopenia - etiology
Thrombocytopenia - genetics
Young Adult
Online Access:Get more information
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Chronic lymphocytic leukemia (CLL) is a multifactorial disease, in which development the important role played the cytokine genes, in particular interleukins. This type of leukemia is more common in the elderly. The purpose of the study was to evaluate the association of genetic polymorphisms of interleukin with the development of chronic lymphocytic leukemia among residents of the Central Chernozem region of Russia. Genotyping of the -889C/T IL-1A, -590C/T IL-4 and VNTR IL-1 Ra was conducted in 206 patients with CLL and 307 individuals of the control group. The study found that the genetic risk factor for the development of CLL is allele -590T IL-4 (OR=-1,45). The development of thrombocytopenia in patients with CLL is associated with genetic variants -889T IL-1A (OR=1,95), -889TT IL-1A (OR=6,2) and IL-1Ra*1 (OR=-2,32).
ISSN:1561-9125