Search Results - "Iakova, Polina"

The ubiquitin ligase Cullin-1 associates with chromatin and regulates transcription of specific c-MYC target genes by Sweeney, Melanie A., Iakova, Polina, Maneix, Laure, Shih, Fu-Yuan, Cho, Hannah E., Sahin, Ergun, Catic, Andre

“…Transcription is regulated through a dynamic interplay of DNA-associated proteins, and the composition of gene-regulatory complexes is subject to continuous…”
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Intracellular signaling and hepatocellular carcinoma by Iakova, Polina, Timchenko, Lubov, Timchenko, Nikolai A

“…Abstract Liver cancer is the fifth most common cancer and the third most common cause of cancer related death in the world. The recent development of new…”
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The reduction of SIRT1 in livers of old mice leads to impaired body homeostasis and to inhibition of liver proliferation by Jin, Jingling, Iakova, Polina, Jiang, Yanjun, Medrano, Estela E., Timchenko, Nikolai A.

“…Age declines liver functions, leading to the development of age‐associated diseases. A member of the sirtuins family, SIRT1, is involved in the control of…”
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Increased Expression of Enzymes of Triglyceride Synthesis Is Essential for the Development of Hepatic Steatosis by Jin, Jingling, Iakova, Polina, Breaux, Meghan, Sullivan, Emily, Jawanmardi, Nicole, Chen, Dahu, Jiang, Yanjun, Medrano, Estela M., Timchenko, Nikolai A.

“…Molecular mechanisms underpinning nonalcoholic fatty liver disease (NAFLD) are not well understood. The earliest step of NAFLD is hepatic steatosis, which is…”
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Overexpression of CUG Triplet Repeat-binding Protein, CUGBP1, in Mice Inhibits Myogenesis by Timchenko, Nikolai A., Patel, Roma, Iakova, Polina, Cai, Zong-Jin, Quan, Ling, Timchenko, Lubov T.

“…Accumulation of RNA CUG repeats in myotonic dystrophy type 1 (DM1) patients leads to the induction of a CUG-binding protein, CUGBP1, which increases…”
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Competition of CUGBP1 and calreticulin for the regulation of p21 translation determines cell fate by Iakova, Polina, Wang, Guo-Li, Timchenko, Lubov, Michalak, Marek, Pereira-Smith, Olivia M, Smith, James R, Timchenko, Nikolai A

“…Induction of p21 in senescent human fibroblasts plays a key role in the inactivation of cyclin‐dependent kinases and the resulting irreversible growth arrest…”
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Molecular Basis for Impaired Muscle Differentiation in Myotonic Dystrophy by Timchenko, Nikolai A., Iakova, Polina, Cai, Zong-Jin, Smith, James R., Timchenko, Lubov T.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Calreticulin Interacts with C/EBPα and C/EBPβ mRNAs and Represses Translation of C/EBP Proteins by Timchenko, Lubov T., Iakova, Polina, Welm, Alana L., Cai, Z.-J., Timchenko, Nikolai A.

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Neuronal SIRPα modulates disease pathology and progression in a mouse model of Alzheimer’s disease by Samuel, Melanie, Iakova, Polina, Abdulwahab, Qudrat, Andrade, Pilar, Jiang, Danye

“…Background Microglia are phagocytic cells that play multiple critical roles in Alzheimer’s disease susceptibility and progress. In parallel, they display…”
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Epigenetic Silencing of MYC By Proteasome Inhibitors by Catic, Andre, Maneix, Laure, Iakova, Polina, Mistry, Ragini, Stossi, Fabio, Yellapragada, Sarvari Venkata, Lulla, Premal D.

“…Proteasome inhibitors were first introduced to the clinic almost 20 years ago and have since become standard of care in multiple myeloma treatment, a cancer of…”
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2028 – CYCLOPHILIN A REGULATES PROTEIN PHASE SEPARATION AND MITIGATES HEMATOPOIETIC STEM CELL AGING by Maneix, Laure, Iakova, Polina, Moree, Shannon, King, Jordon, Scadden, David, Catic, Andre

“…Loss of protein quality is a driving force of aging and the accumulation of misfolded proteins represents a vulnerability for long-lived cells, such as…”
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Protein Phase Separation in Hematopoietic Stem Cell Aging by Maneix, Laure, Iakova, Polina, Moree, Shannon, Sweeney, Melanie, Moka, Nagaishwarya, Yellapragada, Sarvari Venkata, Catic, Andre

“…Imbalanced protein homeostasis (proteostasis) is a driver of aging and a vulnerability for long-lived cells such as hematopoietic stem cells. To determine…”
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Ghrelin deletion protects against age‐associated hepatic steatosis by downregulating the C/EBPα‐p300/DGAT1 pathway by Guillory, Bobby, Jawanmardi, Nicole, Iakova, Polina, Anderson, Barbara, Zang, Pu, Timchenko, Nikolai A., Garcia, Jose M.

“…Summary Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide. NAFLD usually begins as low‐grade hepatic steatosis which further…”
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Imaging-Based Screening of Deubiquitinating Proteases Identifies Otubain-1 as a Stabilizer of c-MYC by Moree, Shannon E, Maneix, Laure, Iakova, Polina, Stossi, Fabio, Sahin, Ergun, Catic, Andre

“…The ubiquitin-proteasome pathway precisely controls the turnover of transcription factors in the nucleus, playing an important role in maintaining appropriate…”
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GSK3β mediates muscle pathology in myotonic dystrophy by Jones, Karlie, Wei, Christina, Iakova, Polina, Bugiardini, Enrico, Schneider-Gold, Christiane, Meola, Giovanni, Woodgett, James, Killian, James, Timchenko, Nikolai A, Timchenko, Lubov T

“…Myotonic dystrophy type 1 (DM1) is a complex neuromuscular disease characterized by skeletal muscle wasting, weakness, and myotonia. DM1 is caused by the…”
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RNA Binding Protein CUGBP1 Inhibits Liver Cancer in a Phosphorylation-Dependent Manner by Lewis, Kyle, Valanejad, Leila, Cast, Ashley, Wright, Mary, Wei, Christina, Iakova, Polina, Stock, Lauren, Karns, Rebekah, Timchenko, Lubov, Timchenko, Nikolai

“…Despite intensive investigations, mechanisms of liver cancer are not known. Here, we identified an important step of liver cancer, which is the neutralization…”
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Abstract 1847: The ubiquitin proteasome system controls cell cycle gene expression through regulation of histone acetylation in multiple myeloma by Maneix, Laure, Iakova, Polina, Moree, Shannon, Fletcher, Luke, Lulla, Premal, Yellapragada, Sarvari V., Catic, Andre

“…Abstract Transcription factors (TFs) are generally short-lived proteins that undergo active turnover. The dynamic interaction of TFs and co-regulators with…”
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Dynamic Regulation of Histone Acetylation By Nuclear Proteolysis Controls Cell Cycle Gene Expression and Chromosome Integrity in Multiple Myeloma by Maneix, Laure, Iakova, Polina, Moree, Shannon, Fletcher, Luke, Lulla, Premal, Yellapragada, Sarvari Venkata, Catic, Andre

“…Transcription factors are generally short-lived proteins that undergo active turnover. The dynamic interaction of transcription factors and co-regulators with…”
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p300 Regulates Liver Functions by Controlling p53 and C/EBP Family Proteins through Multiple Signaling Pathways by Breaux, Meghan, Lewis, Kyle, Valanejad, Leila, Iakova, Polina, Chen, Fengju, Mo, Qianxing, Medrano, Estela, Timchenko, Lubov, Timchenko, Nikolai

“…The histone acetyltransferase p300 has been implicated in the regulation of liver biology; however, molecular mechanisms of this regulation are not known. In…”
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Cooperation of C/EBP family proteins and chromatin remodeling proteins is essential for termination of liver regeneration by Jin, Jingling, Hong, Il‐Hwa, Lewis, Kyle, Iakova, Polina, Breaux, Meghan, Jiang, Yanjun, Sullivan, Emily, Jawanmardi, Nicole, Timchenko, Lubov, Timchenko, Nikolai A.

“…Liver cancer is the fifth most common cancer. A highly invasive surgical resection of the liver tumor is the main approach used to eliminate the tumor…”
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