Search Results - "Iacobas, S."

Oestradiol Regulates Neuropeptide Y Release and Gene Coupling with the GABAergic and Glutamatergic Synapses in the Adult Female Rat Dentate Gyrus by Velíšková, J., Iacobas, D., Iacobas, S., Sidyelyeva, G., Chachua, T., Velíšek, L.

“…Neuropeptide Y (NPY) is an endogenous modulator of neuronal activity affecting both GABAergic and glutamatergic transmission. Previously, we found that…”
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Transcriptome profiling of hippocampal CA1 after early-life seizure-induced preconditioning may elucidate new genetic therapies for epilepsy by Friedman, L. K., Mancuso, J., Patel, A., Kudur, V., Leheste, J. R., Iacobas, S., Botta, J., Iacobas, D. A., Spray, D. C.

“…Injury of the CA1 subregion induced by a single injection of kainic acid (1 × KA) in juvenile animals (P20) is attenuated in animals with two prior sustained…”
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Prenatal Corticosteroids Modify Glutamatergic and GABAergic Synapse Genomic Fabric: Insights from a Novel Animal Model of Infantile Spasms by Iacobas, D. A., Iacobas, S., Chachua, T., Goletiani, C., Sidyelyeva, G., Velíšková, J., Velíšek, L.

“…Prenatal exposure to corticosteroids has long‐term postnatal somatic and neurodevelopmental consequences. Animal studies indicate that corticosteroid…”
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The connexin43-dependent transcriptome during brain development: Importance of genetic background by Iacobas, S, Iacobas, D.A, Spray, D.C, Scemes, E

“…Abstract Use of null mutant mice is a powerful way to evaluate the role of specific proteins in brain function. Studies performed on knockout mice have…”
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Sex-dependent gene regulatory networks of the heart rhythm by Iacobas, D. A., Iacobas, S., Thomas, N., Spray, D. C.

“…Expression level, control, and intercoordination of 66 selected heart rhythm determinant (HRD) genes were compared in atria and ventricles of four male and…”
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Cardiac gene expression and systemic cytokine profile are complementary in a murine model of post-ischemic heart failure by Lachtermacher, S, Esporcatte, B L B, Montalvão, F, Costa, P C, Rodrigues, D C, Belem, L, Rabischoffisky, A, Faria Neto, H C C, Vasconcellos, R, Iacobas, S, Iacobas, D A, Dohmann, H F R, Spray, D C, Goldenberg, R C S, Campos-de-Carvalho, A C

“…After myocardial infarction (MI), activation of the immune system and inflammatory mechanisms, among others, can lead to ventricular remodeling and heart…”
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Prenatal Corticosteroids Modify Glutamatergic and GABA ergic Synapse Genomic Fabric: Insights from a Novel Animal Model of Infantile Spasms by Iacobas, D. A., Iacobas, S., Chachua, T., Goletiani, C., Sidyelyeva, G., Velíšková, J., Velíšek, L.

“…Prenatal exposure to corticosteroids has long‐term postnatal somatic and neurodevelopmental consequences. Animal studies indicate that corticosteroid…”
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Prenatal Corticosteroids Modify Glutamatergic and GABAergic Synapse Genomic Fabric: Insights from a Novel Animal Model of Infantile Spasms: Steroids annd the Nervous System: This special issue has been prepared in association with the 7th International Steroids and the Nervous System Meeting, Turin Italy, February, 2013 by IACOBAS, D. A, IACOBAS, S, CHACHUA, T, GOLETIANI, C, SIDYELYEVA, G, VELISKOVA, J, VELISEK, L

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Connexin43, the major gap junction protein of astrocytes, is down-regulated in inflamed white matter in an animal model of multiple sclerosis by Brand-Schieber, Elimor, Werner, Peter, Iacobas, Dumitru A., Iacobas, Sanda, Beelitz, Michelle, Lowery, Stuart L., Spray, David C., Scemes, Eliana

“…Both multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), its animal model, involve inflammatory attack on central nervous system (CNS)…”
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Connexin43 and the brain transcriptome of newborn mice by Iacobas, Dumitru A., Iacobas, Sanda, Spray, David C.

“…Our previously reported cDNA array datasets from neonatal wild-type and Cx43 −/− (approved gene symbol Gja1) mouse brains were further analyzed to identify…”
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Sensitivity of the brain transcriptome to connexin ablation by Iacobas, Dumitru A., Iacobas, Sanda, Urban-Maldonado, Marcia, Spray, David C.

“…Extensive studies on mice with total or partial disruption of either connexin43 (Cx43) or connexin32 (Cx32) have detected only subtle changes in central…”
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Array analysis of gene expression in connexin-43 null astrocytes by Iacobas, Dumitru A, Urban-Maldonado, Marcia, Iacobas, Sanda, Scemes, Eliana, Spray, David C

“…Department of Neuroscience, Albert Einstein College of Medicine, New York 10461 Connexin-43 (Cx43) is the most abundant gap junction protein in brain, where it…”
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Transcriptomic changes in developing kidney exposed to chronic hypoxia by Iacobas, Dumitru A., Fan, Chenhao, Iacobas, Sanda, Spray, David C., Haddad, Gabriel G.

“…cDNA arrays compared gene expression in kidneys of neonatal mice subjected to 1, 2, and 4 weeks of chronic constant (CCH) or intermittent (CIH) hypoxia with…”
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Membrane bioelectrogenesis and ionic channel activity simulation under drug action by Pennec, J P, Iacobas, A D, Iacobas, S

“…The concept of the ionic channel, as a protein with more discrete ionic conductance levels, is analyzed and a computer program, aiming to simulate its dynamics…”
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Genes controlling multiple functional pathways are transcriptionally regulated in connexin43 null mouse heart by Iacobas, Dumitru A, Iacobas, Sanda, Li, W. E. I, Zoidl, Georg, Dermietzel, Rolf, Spray, David C

“…1 Department of Neuroscience Albert Einstein College of Medicine, Bronx, New York 2 Department of Cardiology, Albert Einstein College of Medicine, Bronx, New…”
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The "patholog" of the genes expression profile, a new tool in defining, evaluating, and classifying genetic diseases by Iacobaş, A D, Iacobaş, S, Spray, D C

“…The paper introduces the pre-Hilbert space of standard gene expression (SSGE) based on the normal variability in gene profiles, as revealed by the "spotting"…”
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Hits and misses from gene expression ratio measurements in cDNA microarray studies by Iacobas, Dumitru A, Massimi, Aldo B, Urban, Marcia, Iacobas, Sanda, Spray, David C

“…DNA microarray users face many challenges to obtain accurate results, including complex technical errors, natural variability of biological systems, imperfect…”
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Basic program in monitoring and analysing of a living system by Iacobaş, A D, Iacobaş, S

“…An easy to use, for a physiologist, BASIC program based on a previous published theory (Iacobaş & Iacobaş 1985, 1987) is presented. The user should introduce…”
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A mathematical transcription of a current problem in physiology by Iacobaş, S, Iacobaş, A D

“…The pre-Hilbert space of normal and pathological states of a living organism is built and a set of functions of medical interest are defined on it. Thus we put…”
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