Search Results - "IZUMIYAMA, Naotaka"

Changes in telomere length with aging in human neurons and glial cells revealed by quantitative fluorescence in situ hybridization analysis by Tomita, Ken‐ichiro, Aida, Junko, Izumiyama‐Shimomura, Naotaka, Nakamura, Ken‐ichi, Ishikawa, Naoshi, Matsuda, Yoko, Arai, Tomio, Ishiwata, Toshiyuki, Kumasaka, Toshio, Takahashi‐Fujigasaki, Junko, Hiraishi, Naoki, Yamada, Misaki, Fujiwara, Mutsunori, Takubo, Kaiyo

“…Aim The telomere is a structure present at the ends of chromosomes, and is known to shorten with aging and successive rounds of cell division. However, very…”
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Changes of telomere length with aging by Takubo, Kaiyo, Aida, Junko, Izumiyama-Shimomura, Naotaka, Ishikawa, Naoshi, Sawabe, Motoji, Kurabayashi, Rie, Shiraishi, Hiroaki, Arai, Tomio, Nakamura, Ken-Ichi

“…We reviewed our methodology and results of telomere measurements, with reference to telomere length and aging. Human tissues always showed telomere shortening…”
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Telomere attrition and restoration in the normal teleost Oryzias latipes are linked to growth rate and telomerase activity at each life stage by Hatakeyama, Hitoshi, Yamazaki, Hiromi, Nakamura, Ken-Ichi, Izumiyama-Shimomura, Naotaka, Aida, Junko, Suzuki, Hiroetsu, Tsuchida, Shuichi, Matsuura, Masaaki, Takubo, Kaiyo, Ishikawa, Naoshi

“…Telomere shortening occurs when cells divide, both in vitro and in vivo. On the other hand, telomerase is able to maintain telomere length in cells by adding…”
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Gradual telomere shortening and increasing chromosomal instability among PanIN grades and normal ductal epithelia with and without cancer in the pancreas by Matsuda, Yoko, Ishiwata, Toshiyuki, Izumiyama-Shimomura, Naotaka, Hamayasu, Hideki, Fujiwara, Mutsunori, Tomita, Ken-Ichiro, Hiraishi, Naoki, Nakamura, Ken-Ichi, Ishikawa, Naoshi, Aida, Junko, Takubo, Kaiyo, Arai, Tomio

“…A large body of evidence supports a key role for telomere dysfunction in carcinogenesis due to the induction of chromosomal instability. To study telomere…”
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Donor age and operational tolerance in living donor liver transplantation by Sanada, Yukihiro, Kawano, Youichi, Ishikawa, Naoshi, Aida, Junko, Nakamura, Ken-ichi, Izumiyama-Shimomura, Naotaka, Urahashi, Taizen, Ihara, Yoshiyuki, Okada, Noriki, Yamada, Naoya, Hirata, Yuta, Takubo, Kaiyo, Mizuta, Koichi

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Luminal and cancer cells in the breast show more rapid telomere shortening than myoepithelial cells and fibroblasts by Kurabayashi, Rie, MD, Takubo, Kaiyo, MD, Aida, Junko, DDS, PhD, Honma, Naoko, MD, Poon, Steven S.S., PhD, Kammori, Makoto, MD, Izumiyama-Shimomura, Naotaka, PhD, Nakamura, Ken-ichi, PhD, Tsuji, Ei-ichi, MD, Matsuura, Masaaki, PhD, Ogawa, Toshihisa, MD, Kaminishi, Michio, MD

“…Summary Critically shortened, dysfunctional telomeres may play a role in the genetic instabilities commonly found in cancer. We analyzed 30 surgical specimens…”
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Chromosomal instability and telomere lengths of each chromosomal arm measured by Q-FISH in human fibroblast strains prior to replicative senescence by Takubo, Kaiyo, Aida, Junko, Izumiyama, Naotaka, Ishikawa, Naoshi, Fujiwara, Mutsunori, Poon, Steven S.S., Kondo, Hiroshi, Kammori, Makoto, Matsuura, Masaaki, Sawabe, Motoji, Arai, Tomio, Baird, Duncan M., Nakamura, Ken-Ichi

“…▶ Q-FISH to measure telomere lengths of p- and q-arms was performed. ▶ Chromosomes with excessively shortened telomeres showed fusions and anaphase bridges. ▶…”
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Telomere length variations in 6 mucosal cell types of gastric tissue observed using a novel quantitative fluorescence in situ hybridization method by Aida, Junko, DDS, PhD, Izumiyama-Shimomura, Naotaka, PhD, Nakamura, Ken-ichi, PhD, Ishii, Akio, DVM, Ishikawa, Naoshi, MD, Honma, Naoko, MD, Kurabayashi, Rie, MD, Kammori, Makoto, MD, Poon, Steven S.S., PhD, Arai, Tomio, MD, Takubo, Kaiyo, MD

“…Summary We developed a novel method for evaluating telomere length in 6 cell types of noncancerous and cancerous mucosal tissues from 11 cases of gastric…”
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Short telomeres and chromosome instability prior to histologic malignant progression and cytogenetic aneuploidy in papillary urothelial neoplasms by Izumiyama-Shimomura, Naotaka, M.D, Nakamura, Ken-ichi, Ph.D, Aida, Junko, D.D.S., Ph.D, Ishikawa, Naoshi, M.D, Kuroiwa, Mie, M.D, Hiraishi, Naoki, Fujiwara, Mutsunori, M.D, Ishikawa, Yuichi, M.D, Inoshita, Naoko, M.D, Yonese, Junji, M.D, Matsuura, Masaaki, Ph.D, Poon, Steven S.S., Ph.D, Arai, Tomio, M.D, Takubo, Kaiyo, M.D

“…Abstract Purpose Evaluation of the relationships existing among 3 histologic types of urothelial tumors, chromosomal instability, and telomere length. Patients…”
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Animal model of dementia induced by entorhinal synaptic damage and partial restoration of cognitive deficits by BDNF and carnitine by Ando, Susumu, Kobayashi, Satoru, Waki, Hatsue, Kon, Kazuo, Fukui, Fumiko, Tadenuma, Tomoko, Iwamoto, Machiko, Takeda, Yasuo, Izumiyama, Naotaka, Watanabe, Kazutada, Nakamura, Hiroaki

“…A rat dementia model with cognitive deficits was generated by synapse‐specific lesions using botulinum neurotoxin (BoNTx) type B in the entorhinal cortex. To…”
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Telomere length dynamics in the human pituitary gland: robust preservation throughout adult life to centenarian age by Ishikawa, Naoshi, Nakamura, Ken-Ichi, Izumiyama, Naotaka, Aida, Junko, Sawabe, Motoji, Arai, Tomio, Kishimoto, Hiroshi, Fujiwara, Mutsunori, Ishii, Akio, Takubo, Kaiyo

“…Many studies have demonstrated the association between telomere length in mitotic cells and aging, but the relationship between telomere length in post-mitotic…”
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Quantitative fluorescence in situ hybridization for investigation of telomere length dynamics in the pituitary gland using samples from 128 autopsied patients by Hiraishi, Naoki, Terai, Masanori, Fujiwara, Mutsunori, Aida, Junko, Izumiyama-Shimomura, Naotaka, Ishikawa, Naoshi, Tomita, Ken-ichiro, Matsuda, Yoko, Arai, Tomio, Takubo, Kaiyo, Ishiwata, Toshiyuki

“…•We analyzed telomere lengths in the pituitary gland, glandular cells, and pituicytes.•Telomeres in the adenohypophysis shortened with aging, but those of…”
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Changes of telomere status with aging: An update by Ishikawa, Naoshi, Nakamura, Ken-Ichi, Izumiyama-Shimomura, Naotaka, Aida, Junko, Matsuda, Yoko, Arai, Tomio, Takubo, Kaiyo

“…Accumulated data have shown that most human somatic cells or tissues show irreversible telomere shortening with age, and that there are strong associations…”
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Arm-specific telomere dynamics of each individual chromosome in induced pluripotent stem cells revealed by quantitative fluorescence in situ hybridization by Terai, Masanori, Izumiyama-Shimomura, Naotaka, Aida, Junko, Ishikawa, Naoshi, Kuroiwa, Mie, Arai, Tomio, Toyoda, Masashi, Nakamura, Ken-ichi, Takubo, Kaiyo

“…Abstract We have reported that telomere fluorescence units (TFUs) of established induced pluripotent stem cells (iPSCs) derived from human amnion (hAM933) and…”
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Investigation of telomere length dynamics in induced pluripotent stem cells using quantitative fluorescence in situ hybridization by Terai, Masanori, Izumiyama-Shimomura, Naotaka, Aida, Junko, Ishikawa, Naoshi, Kuroiwa, Mie, Poon, Steven S.S, Arai, Tomio, Toyoda, Masashi, Akutsu, Hidenori, Umezawa, Akihiro, Nakamura, Ken-ichi, Takubo, Kaiyo

“…Abstract Here we attempted to clarify telomere metabolism in parental cells and their derived clonal human induced pluripotent stem cells (iPSCs) at different…”
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Histopathogenesis of early-stage mitral annular calcification by Arounlangsy, Phetsamone, Sawabe, Motoji, Izumiyama, Naotaka, Koike, Morio

“…Mitral annular calcification (MAC) is a common condition in elderly subjects that sometimes causes degenerative mitral valvular diseases. To investigate the…”
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Telomere length of gallbladder epithelium is shortened in patients with congenital biliary dilatation: measurement by quantitative fluorescence in situ hybridization by Aoki, Yuto, Aida, Junko, Kawano, Youichi, Nakamura, Ken-ichi, Izumiyama-Shimomura, Naotaka, Ishikawa, Naoshi, Arai, Tomio, Nakamura, Yoshiharu, Taniai, Nobuhiko, Uchida, Eiji, Takubo, Kaiyo, Ishiwata, Toshiyuki

“…Background Congenital biliary dilatation (CBD) is a congenital malformation involving both dilatation of the extrahepatic bile duct and pancreaticobiliary…”
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Telomere metabolism and diagnostic demonstration of telomere measurement in the human esophagus for distinguishing benign from malignant tissue by tissue quantitative fluorescence in situ hybridization by Kammori, Makoto, Izumiyama, Naotaka, Nakamura, Ken-ichi, Kurabayashi, Rie, Kashio, Mitsuhiko, Aida, Junko, Poon, Steven S S, Kaminishi, Michio

“…We have developed a novel method for evaluating telomere length in four different cell types in non-cancerous and cancerous mucosal tissue from 15 cases of…”
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Q-FISH measurement of hepatocyte telomere lengths in donor liver and graft after pediatric living-donor liver transplantation: donor age affects telomere length sustainability by Kawano, Youichi, Ishikawa, Naoshi, Aida, Junko, Sanada, Yukihiro, Izumiyama-Shimomura, Naotaka, Nakamura, Ken-ichi, Poon, Steven S S, Matsumoto, Koshi, Mizuta, Koichi, Uchida, Eiji, Tajiri, Takashi, Kawarasaki, Hideo, Takubo, Kaiyo

“…Along with the increasing need for living-donor liver transplantation (LDLT), the issue of organ shortage has become a serious problem. Therefore, the use of…”
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Quantitative fluorescence in situ hybridization measurement of telomere length in skin with/without sun exposure or actinic keratosis by Ikeda, Hiroyuki, MD, Aida, Junko, DDS, PhD, Hatamochi, Atsushi, MD, Hamasaki, Yoichiro, MD, Izumiyama-Shimomura, Naotaka, MD, Nakamura, Ken-ichi, PhD, Ishikawa, Naoshi, MD, Poon, Steven S., PhD, Fujiwara, Mutsunori, MD, Tomita, Ken-ichiro, MT, Hiraishi, Naoki, MT, Kuroiwa, Mie, PhD, Matsuura, Masaaki, PhD, Sanada, Yukihiro, MD, Kawano, Youichi, MD, Arai, Tomio, MD, Takubo, Kaiyo, MD

“…Summary Chromosomal and genomic instability due to telomere dysfunction is known to play an important role in carcinogenesis. To study telomere shortening in…”
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