Search Results - "IZUMI, HIROKI"

Muscarinic receptors promote castration-resistant growth of prostate cancer through a FAK–YAP signaling axis by Goto, Yusuke, Ando, Toshinori, Izumi, Hiroki, Feng, Xiaodong, Arang, Nadia, Gilardi, Mara, Wang, Zhiyong, Ando, Kazuyo, Gutkind, J. Silvio

“…Prostate cancer (PCa) innervation contributes to the progression of PCa. However, the precise impact of innervation on PCa cells is still poorly understood. By…”
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A Large-Scale Prospective Concordance Study of Plasma- and Tissue-Based Next-Generation Targeted Sequencing for Advanced Non-Small Cell Lung Cancer (LC-SCRUM-Liquid) by Sugimoto, Akira, Matsumoto, Shingo, Udagawa, Hibiki, Itotani, Ryo, Usui, Yuko, Umemura, Shigeki, Nishino, Kazumi, Nakachi, Ichiro, Kuyama, Shoichi, Daga, Haruko, Hara, Satoshi, Miyamoto, Shingo, Kato, Terufumi, Sakakibara-Konishi, Jun, Tabata, Eriko, Nakagawa, Taku, Kawaguchi, Tomoya, Sakai, Tetsuya, Shibata, Yuji, Izumi, Hiroki, Nosaki, Kaname, Zenke, Yoshitaka, Yoh, Kiyotaka, Goto, Koichi

“…We evaluated plasma cell-free DNA (cfDNA) and tissue-based sequencing concordance for comprehensive oncogenic driver detection in non-small cell lung cancer…”
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The CLIP1–LTK fusion is an oncogenic driver in non‐small‐cell lung cancer by Izumi, Hiroki, Matsumoto, Shingo, Liu, Jie, Tanaka, Kosuke, Mori, Shunta, Hayashi, Kumiko, Kumagai, Shogo, Shibata, Yuji, Hayashida, Takuma, Watanabe, Kana, Fukuhara, Tatsuro, Ikeda, Takaya, Yoh, Kiyotaka, Kato, Terufumi, Nishino, Kazumi, Nakamura, Atsushi, Nakachi, Ichiro, Kuyama, Shoichi, Furuya, Naoki, Sakakibara-Konishi, Jun, Okamoto, Isamu, Taima, Kageaki, Ebi, Noriyuki, Daga, Haruko, Yamasaki, Akira, Kodani, Masahiro, Udagawa, Hibiki, Kirita, Keisuke, Zenke, Yoshitaka, Nosaki, Kaname, Sugiyama, Eri, Sakai, Tetsuya, Nakai, Tokiko, Ishii, Genichiro, Niho, Seiji, Ohtsu, Atsushi, Kobayashi, Susumu S., Goto, Koichi

“…Lung cancer is one of the most aggressive tumour types. Targeted therapies stratified by oncogenic drivers have substantially improved therapeutic outcomes in…”
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Squamous Cell Carcinoma Transformation from EGFR-mutated Lung Adenocarcinoma: A Case Report and Literature Review by Izumi, Hiroki, Yamasaki, Akira, Ueda, Yasuto, Sumikawa, Takashi, Maeta, Hiroyuki, Nakamoto, Shu, Shimizu, Eiji

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EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1 by Ando, Toshinori, Arang, Nadia, Wang, Zhiyong, Costea, Daniela Elena, Feng, Xiaodong, Goto, Yusuke, Izumi, Hiroki, Gilardi, Mara, Ando, Kazuyo, Gutkind, J. Silvio

“…The Hippo pathway is frequently dysregulated in cancer, leading to the unrestrained activity of its downstream targets, YAP/TAZ, and aberrant tumor growth…”
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The impact of tertiary lymphoid structures on clinicopathological, genetic and gene expression characteristics in lung adenocarcinoma by Tamiya, Yutaro, Nakai, Tokiko, Suzuki, Ayako, Mimaki, Sachiyo, Tsuchihara, Katsuya, Sato, Kei, Yoh, Kiyotaka, Matsumoto, Shingo, Zenke, Yoshitaka, Nosaki, Kaname, Izumi, Hiroki, Shibata, Yuji, Sakai, Tetsuya, Taki, Tetsuro, Miyazaki, Saori, Watanabe, Reiko, Sakamoto, Naoya, Sakashita, Shingo, Kojima, Motohiro, Hashimoto, Naozumi, Tsuboi, Masahiro, Goto, Koichi, Ishii, Genichiro

“…•The presence of tertiary lymphoid structures (TLS) was associated with significantly lower risk of recurrence.•TLS presence was not associated with PD-L1…”
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Successful Treatment with Crizotinib to Overcome Drug Resistance Possibly Due to Mesenchymal-epithelial Transition Amplification in a Lung Cancer Patient with the Echinoderm Microtubule-associated Protein-like 4-anaplastic Lymphoma Kinase Fusion Gene by Shiraishi, Tomoko, Yamasaki, Kei, Kidogawa, Moe, Shingu, Tatsuya, Ujimiya, Fuki, Jotatsu, Takanobu, Matsumoto, Shingo, Izumi, Hiroki, Nishida, Chinatsu, Goto, Koichi, Yatera, Kazuhiro

“…Amplification of the mesenchymal-epithelial transition (MET) gene plays an important role in anticancer drug resistance to anaplastic lymphoma kinase-tyrosine…”
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Successful treatment with dupilumab for mucus plugs in severe asthma by Anai, Moriyasu, Yoshida, Chieko, Izumi, Hiroki, Muramoto, Kei, Saruwatari, Koichi, Tomita, Yusuke, Ichiyasu, Hidenori, Sakagami, Takuro

“…A 29‐year‐old man presented to our hospital with severe eosinophilic asthma. He needed a short OCS burst for exacerbation of asthma once every 1 or 2 months,…”
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Volume Transmission of Substance P in Striatum Induced by Intraplantar Formalin Injection Attenuates Nociceptive Responses via Activation of the Neurokinin 1 Receptor by Nakamura, Yoki, Izumi, Hiroki, Shimizu, Takumi, Hisaoka-Nakashima, Kazue, Morioka, Norimitsu, Nakata, Yoshihiro

“…To clarify a role of substance P (SP) in an endogenous pain control mechanism involving the rat striatum, striatal SP release was measured over time by…”
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The EGFR C797S Mutation Confers Resistance to a Novel EGFR Inhibitor CLN-081 to EGFR Exon 20 Insertion Mutations by Kagawa, Yosuke, Hayashida, Takuma, Liu, Jie, Mori, Shunta, Izumi, Hiroki, Kumagai, Shogo, Udagawa, Hibiki, Hattori, Noboru, Goto, Koichi, Kobayashi, Susumu S.

“…EGFR exon 20 insertion mutations account for 5% to 10% of EGFR-mutated NSCLC. CLN-081 (formerly known as TAS6417), a novel covalent EGFR tyrosine kinase…”
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LTK mutations responsible for resistance to lorlatinib in non-small cell lung cancer harboring CLIP1-LTK fusion by Mori, Shunta, Izumi, Hiroki, Araki, Mitsugu, Liu, Jie, Tanaka, Yu, Kagawa, Yosuke, Sagae, Yukari, Ma, Biao, Isaka, Yuta, Sasakura, Yoko, Kumagai, Shogo, Sakae, Yuta, Tanaka, Kosuke, Shibata, Yuji, Udagawa, Hibiki, Matsumoto, Shingo, Yoh, Kiyotaka, Okuno, Yasushi, Goto, Koichi, Kobayashi, Susumu S.

“…The CLIP1-LTK fusion was recently discovered as a novel oncogenic driver in non-small cell lung cancer (NSCLC). Lorlatinib, a third-generation ALK inhibitor,…”
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Study on Characteristics of Tensile Strength of Concrete Considering Temperature Dependence in Mass Concrete Structures by Izumi, Hiroki, Arai, Juniti, Mizobuchi, Toshiaki

“…It is important to grasp mechanical and thermal properties in order to verify the possibility of thermal cracking. In this study, for the purpose of improving…”
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A novel SLC34A2 mutation in a patient with pulmonary alveolar microlithiasis by Izumi, Hiroki, Kurai, Jun, Kodani, Masahiro, Watanabe, Masanari, Yamamoto, Akihiro, Nanba, Eiji, Adachi, Kaori, Igishi, Tadashi, Shimizu, Eiji

“…Pulmonary alveolar microlithiasis (PAM) is a rare autosomal recessive disease caused by mutations in SLC34A2 and characterized by intra-alveolar accumulation…”
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Favorable effect of the combination of vinorelbine and dihydropyrimidine dehydrogenase-inhibitory fluoropyrimidine in EGFR-mutated lung adenocarcinoma: Retrospective and in vitro studies by IZUMI, HIROKI, TOUGE, HIROKAZU, IGISHI, TADASHI, MAKINO, HARUHIKO, NISHII-ITO, SHIZUKA, TAKATA, MIYAKO, NAKAZAKI, HIROFUMI, UEDA, YASUTO, MATSUMOTO, SHINGO, KODANI, MASAHIRO, KURAI, JUN, TAKEDA, KENICHI, SAKAMOTO, TOMOHIRO, YANAI, MASAAKI, TANAKA, NATSUMI, NIRODI, CHAITANYA S, SHIMIZU, EIJI

“…Although cytotoxic chemotherapy is essential in epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC), it is unclear which regimen…”
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A case of lung abscess successfully treated by transbronchial drainage using a guide sheath by Izumi, Hiroki, Kodani, Masahiro, Matsumoto, Shingo, Kawasaki, Yuji, Igishi, Tadashi, Shimizu, Eiji

“…A 51‐year‐old man was diagnosed with colon cancer in September 2011, and a solitary pulmonary nodule was detected by computed tomography (CT) scan. We…”
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Generation of embryonic stem cell lines from immature rabbit ovarian follicles by Teramura, Takeshi, Sugimoto, Hironobu, Frampton, John, Kida, Yuta, Nakano, Miho, Kawakami, Makiko, Izumi, Hiroki, Fukunaga, Naoto, Onodera, Yuta, Takehara, Toshiyuki, Fukuda, Kanji, Hosoi, Yoshihiko

“…In mammalian ovaries, many immature follicles remain after the dominant follicles undergo ovulation. Here we report the successful production of rabbit…”
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Cysteamine supplementation during in vitro maturation (IVM) of rabbit oocyte improves the developmental capacity after intracytoplasmic sperm injection by Izumi, Hiroki, Miyamoto, Yuki, Mori, Tatsufumi, Hashigami, Yuka, Chiba, Yasutaka, Teramura, Takeshi, Hashimoto, Shu, Fukuda, Kanji, Morimoto, Yoshiharu, Hosoi, Yoshihiko

“…Purpose Current approaches to in vitro maturation (IVM) may result in low efficiency and inadequate quality of the oocytes due to insufficient cytoplasmic…”
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Large Cell Neuroendocrine Carcinoma Arising from the Left Main Bronchus by Tokuyasu, Hirokazu, Sakaguchi, Yasuto, Isowa, Noritaka, Izumi, Hiroki, Takeda, Kenichi, Miura, Hiroshi, Shimizu, Eiji

“…A 67-year-old man was referred to our hospital for a detailed medical examination of a bronchial polyp that was detected during chest computed tomography…”
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Small Cell Lung Cancer Complicated by Pulmonary Sarcoidosis by Tokuyasu, Hirokazu, Izumi, Hiroki, Mukai, Natsuko, Takeda, Kenichi, Sakaguchi, Yasuto, Isowa, Noritaka, Shimizu, Eiji

“…In July 2009, a 69-year-old man was admitted to our hospital because an abnormal chest shadow had been noted on medical examination. Chest radiography and…”
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Tarlatamab, a First-in-Class DLL3-Targeted Bispecific T-Cell Engager, in Recurrent Small-Cell Lung Cancer: An Open-Label, Phase I Study by Paz-Ares, Luis, Champiat, Stephane, Lai, W Victoria, Izumi, Hiroki, Govindan, Ramaswamy, Boyer, Michael, Hummel, Horst-Dieter, Borghaei, Hossein, Johnson, Melissa L, Steeghs, Neeltje, Blackhall, Fiona, Dowlati, Afshin, Reguart, Noemi, Yoshida, Tatsuya, He, Kai, Gadgeel, Shirish M, Felip, Enriqueta, Zhang, Yiran, Pati, Amrita, Minocha, Mukul, Mukherjee, Sujoy, Goldrick, Amanda, Nagorsen, Dirk, Hashemi Sadraei, Nooshin, Owonikoko, Taofeek K

“…Small-cell lung cancer (SCLC) is an aggressive malignancy with limited treatments. Delta-like ligand 3 (DLL3) is aberrantly expressed in most SCLC. Tarlatamab…”
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