Search Results - "IZUI, S."

FcγRI (CD64) Contributes Substantially to Severity of Arthritis, Hypersensitivity Responses, and Protection from Bacterial Infection by Ioan-Facsinay, A, de Kimpe, S.J, Hellwig, S.M.M, van Lent, P.L, Hofhuis, F.M.A, van Ojik, H.H, Sedlik, C, da Silveira, S.A, Gerber, J, de Jong, Y.F, Roozendaal, R, Aarden, L.A, van den Berg, W.B, Saito, T, Mosser, D, Amigorena, S, Izui, S, van Ommen, G-J.B, van Vugt, M, van de Winkel, J.G.J, Verbeek, J.S

“…The high-affinity receptor for IgG, FcγRI, shares its capacity to bind IgG2a immune complexes (IgG2a-IC) with the low-affinity receptor FcγRIII and complement…”
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Tonic B cell activation by Radioprotective105/MD-1 promotes disease progression in MRL/lpr mice by Kobayashi, Toshihiko, Takahashi, Koichiro, Nagai, Yoshinori, Shibata, Takuma, Otani, Masako, Izui, Shozo, Akira, Shizuo, Gotoh, Yoshiyuki, Kiyono, Hiroshi, Miyake, Kensuke

“…Toll-like receptors (TLRs) have a crucial role in sensing microbial products and triggering immune responses. Recent reports have indicated that TLR7 and TLR9…”
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Genetic susceptibility to PolyI:C-induced IFNα/β-dependent accelerated disease in lupus-prone mice by Jorgensen, T N, Thurman, J, Izui, S, Falta, M T, Metzger, T E, Flannery, S A, Kappler, J, Marrack, P, Kotzin, B L

“…Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown etiology. Associations between viral infections and the onset of SLE have been…”
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Prolactin influences autoimmune disease activity in the female B/W mouse by McMurray, R, Keisler, D, Kanuckel, K, Izui, S, Walker, SE

“…Prolactin, an anterior pituitary hormone, stimulates humoral and cell-mediated immunity. This study investigated effects of manipulating prolactin levels in…”
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Genetic linkage of IgG autoantibody production in relation to lupus nephritis in New Zealand hybrid mice by Vyse, T J, Drake, C G, Rozzo, S J, Roper, E, Izui, S, Kotzin, B L

“…F1 hybrids of New Zealand black (NZB) and New Zealand white (NZW) mice are a model of human systemic lupus erythematosus. These mice develop a severe immune…”
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Autoantigen Glycoprotein 70 Expression Is Regulated by a Single Locus, Which Acts as a Checkpoint for Pathogenic Anti-Glycoprotein 70 Autoantibody Production and Hence for the Corresponding Development of Severe Nephritis, in Lupus-Prone BXSB Mice by Haywood, MEK, Vyse, T J, McDermott, A, Thompson, E M, Ida, A, Walport, MJ, Izui, S, Morley, B J

“…Retroviral envelope glycoprotein gp70 is present in the sera of immunologically normal and autoimmune-prone strains of mice. However, only lupus-prone mice…”
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Variability of the inhibition by total immunoglobulin of in vitro autoantibody-mediated erythrophagocytosis by mouse macrophages by Leonard, S, Pierard, I, Michaelsen, TE, Izui, S, Masson, P L, Coutelier, J-P

“…Several autoimmune diseases, mainly autoantibody-mediated, are attenuated by infusion of total IgG (IVIg). The efficacy varies widely from one patient to…”
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Variability of the inhibition by total immunoglobulin of in vitro autoantibody‐mediated erythrophagocytosis by mouse macrophages by Léonard, S., Pierard, I., Michaelsen, T. E., Izui, S., Masson, P. L., Coutelier, J.‐P.

“…Summary Several autoimmune diseases, mainly autoantibody‐mediated, are attenuated by infusion of total IgG (IVIg). The efficacy varies widely from one patient…”
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Lessons from BXSB and Related Mouse Models by Izui, Shozo, Ibnou-Zekri, Nabila, Fossati-jimack, Liliane, Iwamoto, Masahiro

“…The BXSB murine strain spontaneously develops an autoimmune syndrome with features of systemic lupus erythematosus (SLE) that affects males much earlier than…”
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Polyclonal B cell activation arises from different mechanisms in lupus- prone (NZB x NZW)F1 and MRL/MpJ-lpr/lpr mice by Merino, R, Iwamoto, M, Fossati, L, Izui, S

“…The polyclonal B cell activation is the earliest and most common immunologic abnormality in lupus-prone mice. However, its cellular mechanism(s) has not been…”
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Control of Separate Pathogenic Autoantibody Responses Marks MHC Gene Contributions to Murine Lupus by Vyse, Timothy J., Halterman, Richard K., Rozzo, Stephen J., Izui, Shozo, Kotzin, Brian L.

“…Previous studies have suggested that MHC and non-MHC genes contribute to the development of autoimmune disease in F1 hybrids of New Zealand black (NZB) and…”
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Induction of various autoantibodies by mutant gene lpr in several strains of mice by Izui, S, Kelley, VE, Masuda, K, Yoshida, H, Roths, JB, Murphy, ED

“…The effect of the autosomal mutant gene lpr (lymphoproliferation) on the development of various autoantibodies and immune complex (IC) glomerulonephritis was…”
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A fish oil diet rich in eicosapentaenoic acid reduces cyclooxygenase metabolites, and suppresses lupus in MRL-lpr mice by Kelley, VE, Ferretti, A, Izui, S, Strom, TB

“…Dietary supplementation of fish oil as the exclusive source of lipid suppresses autoimmune lupus in MRL-lpr mice. This marine oil diet decreases the lymphoid…”
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Immunoglobulin Heavy Chain Constant Region Determines the Pathogenicity and the Antigen-Binding Activity of Rheumatoid Factor by Fulpius, Thierry, Spertini, Francois, Reininger, Luc, Izui, Shozo

“…An IgG3 monoclonal antibody, 6-19, derived from unmanipulated MRL/MpJ-lpr/lpr mice, exhibiting cryoglobulin and anti-IgG2a rheumatoid factor activities,…”
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Isotype-dependent pathogenicity of autoantibodies: analysis in experimental autoimmune hemolytic anemia by Izui, S, Fossati-Jimack, L, da Silveira, S A, Moll, T

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Cryoglobulinemia Induced by a Murine IgG3 Rheumatoid Factor: Skin Vasculitis and Glomerulonephritis Arise from Distinct Pathogenic Mechanisms by Reininger, Luc, Berney, Thierry, Shibata, Takanori, Spertini, Francois, Merino, Ramon, Izui, Shozo

“…MRL-lpr/lpr mice spontaneously develop a lupus-like syndrome characterized by immunopathological manifestations such as necrotizing vascular lesions of ear…”
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Long-Term Observations of Autoimmune-Prone Mice Treated for Autoimmune Disease by Allogeneic Bone Marrow Transplantation by Ikehara, Susumu, Yasumizu, Ryoji, Inaba, Muneo, Izui, Shozo, Hayakawa, Kyoko, Sekita, Ken'Ichi, Toki, Junko, Sugiura, Kikuya, Iwai, Hiroshi, Nakamura, Takao, Muso, Eri, Hamashima, Yoshihiro, Good, Robert A.

“…Long-term effects of allogeneic bone marrow transplantation (ABMT) across major histocompatibility complex barriers were studied in (NZB × NZW)F1(B/W), BXSB,…”
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IgG3 is the major source of cryoglobulins in mice by Abdelmoula, M, Spertini, F, Shibata, T, Gyotoku, Y, Luzuy, S, Lambert, PH, Izui, S

“…A total of 20 of 23 IgG3 mAb derived from unmanipulated autoimmune MRL/MpJ-lpr/lpr mice was shown to generate cryoglobulins which were composed exclusively of…”
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Selective autoantibody production by Yaa+ B cells in autoimmune Yaa+-Yaa- bone marrow chimeric mice by MERINO, R, FOSSATI, L, LACOUR, M, IZUI, S

“…The accelerated autoimmune syndrome observed in BXSB/MpJ male mice is associated with the presence on the Y chromosome of an as yet unidentified mutant gene,…”
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An experimental model of cryoglobulin-associated vasculitis in mice by Pastore, Y, Lajaunias, F, Kuroki, A, Moll, T, Kikuchi, S, Izui, S

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