Search Results - "IWAMARU, Yoshifumi"

Heparan Sulfate and Heparin Promote Faithful Prion Replication in Vitro by Binding to Normal and Abnormal Prion Proteins in Protein Misfolding Cyclic Amplification by Imamura, Morikazu, Tabeta, Naoko, Kato, Nobuko, Matsuura, Yuichi, Iwamaru, Yoshifumi, Yokoyama, Takashi, Murayama, Yuichi

“…The precise mechanism underlying the conversion of normal prion protein (PrPC) into abnormal prion protein (PrPSc) remains unclear. Protein misfolding cyclic…”
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Extended application of the rapid post‐mortem test kit for bovine spongiform encephalopathy to chronic wasting disease by Matsuura, Yuichi, Miyazawa, Kohtaro, Horiuchi, Motohiro, Suzuki, Akio, Yokoyama, Mayumi, Imamura, Morikazu, Ikeda, Keigo, Iwamaru, Yoshifumi

“…Chronic wasting disease (CWD) is a prion disease affecting cervid species primarily in the United States of America and Canada; however, it is now emerging in…”
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Epidermal growth factor-nanoparticle conjugates change the activity from anti-apoptotic to pro-apoptotic at membrane rafts by Yamamoto, Shota, Iwamaru, Yoshifumi, Shimizu, Yoshihisa, Ueda, Yoshibumi, Sato, Moritoshi, Yamaguchi, Kazuo, Nakanishi, Jun

“…[Display omitted] The proliferation epidermal growth factor (EGF) is known to acquire contradictory apoptotic activities upon conjugation with gold…”
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First case of atypical scrapie in a goat in Japan by MATSUURA, Yuichi, MIYAZAWA, Kohtaro, IMAMURA, Morikazu, YOKOYAMA, Takashi, IWAMARU, Yoshifumi

“…Atypical scrapie in goats has only been reported in European countries. The present study reports the identification of the first case of atypical scrapie in…”
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Oral Transmission of L-Type Bovine Spongiform Encephalopathy Agent among Cattle by Okada, Hiroyuki, Iwamaru, Yoshifumi, Imamura, Morikazu, Miyazawa, Kohtaro, Matsuura, Yuichi, Masujin, Kentaro, Murayama, Yuichi, Yokoyama, Takashi

“…To determine oral transmissibility of the L-type bovine spongiform encephalopathy (BSE) prion, we orally inoculated 16 calves with brain homogenates of the…”
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Identification of the first case of atypical scrapie in Japan by IMAMURA, Morikazu, MIYAZAWA, Kohtaro, IWAMARU, Yoshifumi, MATSUURA, Yuichi, YOKOYAMA, Takashi, OKADA, Hiroyuki

“…A Corriedale ewe was confirmed as the first atypical scrapie case during an active surveillance program for transmissible spongiform encephalopathies in small…”
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Transmission of atypical scrapie to homozygous ARQ sheep by OKADA, Hiroyuki, MIYAZAWA, Kohtaro, IMAMURA, Morikazu, IWAMARU, Yoshifumi, MASUJIN, Kentaro, MATSUURA, Yuichi, YOKOYAMA, Takashi

“…Two Cheviot ewes homozygous for the A136L141R154Q171 (AL141RQ) prion protein (PrP) genotype were exposed intracerebrally to brain pools prepared using four…”
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The Activation of P2X7 Receptor Impairs Lysosomal Functions and Stimulates the Release of Autophagolysosomes in Microglial Cells by Takenouchi, Takato, Nakai, Masaaki, Iwamaru, Yoshifumi, Sugama, Shuei, Tsukimoto, Mitsutoshi, Fujita, Masayo, Wei, Jianshe, Sekigawa, Akio, Sato, Mitsuru, Kojima, Shuji, Kitani, Hiroshi, Hashimoto, Makoto

“…Recently, autophagy has been associated with the TLR signaling pathway to eliminate intracellular pathogens in the innate immune system. However, it is unknown…”
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Estimation of prion infectivity in tissues of cattle infected with atypical BSE by real time-quaking induced conversion assay by SAWADA, Kazuhei, SUZUKI, Akio, YAMASAKI, Takeshi, IWAMARU, Yoshifumi, MATSUURA, Yuichi, MIYAZAWA, Kohtaro, MASUJIN, Kentaro, ATARASHI, Ryuichiro, HORIUCHI, Motohiro

“…Atypical bovine spongiform encephalopathy (BSE), first identified in 2004, poses a threat due to the potential to spread the disease to cattle and other…”
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PrPSc with Seeding Activity Extensively Overlaps with Proteinase-Resistant PrPSc Rather than Infectious PrPSc by Iwamaru, Yoshifumi, Matsuura, Yuichi, Miyazawa, Kohtaro

“…The disease-associated prion protein (PrPSc) has the ability to seed the conformational conversion of normal prion proteins into the amyloid fibril form. This…”
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P2X7 Receptor Signaling Pathway as a Therapeutic Target for Neurodegenerative Diseases by Takenouchi, Takato, Sekiyama, Kazunari, Sekigawa, Akio, Fujita, Masayo, Waragai, Masaaki, Sugama, Shuei, Iwamaru, Yoshifumi, Kitani, Hiroshi, Hashimoto, Makoto

“…A recent study suggested that neuroinflammation plays a major role in the pathogenesis of a number of neurodegenerative diseases such as Alzheimer’s disease…”
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Inactivation of Scrapie Prions by the Electrically Charged Disinfectant CAC-717 by Sakudo, Akikazu, Iwamaru, Yoshifumi, Furusaki, Koichi, Haritani, Makoto, Onishi, Rumiko, Imamura, Morikazu, Yokoyama, Takashi, Yoshikawa, Yasuhiro, Onodera, Takashi

“…Previous studies have revealed that the electrically charged disinfectant CAC-717 has strong virucidal and bactericidal effects but is safe for humans and…”
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Emergence of a novel bovine spongiform encephalopathy (BSE) prion from an atypical H-type BSE by Masujin, Kentaro, Okada, Hiroyuki, Miyazawa, Kohtaro, Matsuura, Yuichi, Imamura, Morikazu, Iwamaru, Yoshifumi, Murayama, Yuichi, Yokoyama, Takashi

“…The H-type of atypical bovine spongiform encephalopathy (H-BSE) was serially passaged in bovinized transgenic (TgBoPrP) mice. At the fourth passage, most…”
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Proximity of SCG10 and prion protein in membrane rafts by Iwamaru, Yoshifumi, Kitani, Hiroshi, Okada, Hiroyuki, Takenouchi, Takato, Shimizu, Yoshihisa, Imamura, Morikazu, Miyazawa, Kohtaro, Murayama, Yuichi, Hoover, Edward A., Yokoyama, Takashi

“…The conversion of normal cellular prion protein (PrPC) into its pathogenic isoform (PrPSc) is an essential event in prion pathogenesis. In culture models,…”
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Experimental H-type bovine spongiform encephalopathy characterized by plaques and glial- and stellate-type prion protein deposits by Okada, Hiroyuki, Iwamaru, Yoshifumi, Imamura, Morikazu, Masujin, Kentaro, Matsuura, Yuichi, Shimizu, Yoshihisa, Kasai, Kazuo, Mohri, Shirou, Yokoyama, Takashi, Czub, Stefanie

“…Atypical bovine spongiform encephalopathy (BSE) has recently been identified in Europe, North America, and Japan. It is classified as H-type and L-type BSE…”
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Prion Replication Elicits Cytopathic Changes in Differentiated Neurosphere Cultures by Iwamaru, Yoshifumi, Takenouchi, Takato, Imamura, Morikazu, Shimizu, Yoshihisa, Miyazawa, Kohtaro, Mohri, Shirou, Yokoyama, Takashi, Kitani, Hiroshi

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Interspecies transmission to bovinized transgenic mice uncovers new features of a CH1641-like scrapie isolate by Miyazawa, Kohtaro, Masujin, Kentaro, Matsuura, Yuichi, Iwamaru, Yoshifumi, Yokoyama, Takashi, Okada, Hiroyuki

“…In animal prion diseases, including bovine spongiform encephalopathy (BSE) in cattle, chronic wasting disease in cervids, and scrapie in sheep and goats, a…”
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Sulfated dextrans enhance in vitro amplification of bovine spongiform encephalopathy PrP(Sc) and enable ultrasensitive detection of bovine PrP(Sc) by Murayama, Yuichi, Yoshioka, Miyako, Masujin, Kentaro, Okada, Hiroyuki, Iwamaru, Yoshifumi, Imamura, Morikazu, Matsuura, Yuichi, Fukuda, Shigeo, Onoe, Sadao, Yokoyama, Takashi, Mohri, Shirou

“…Prions, infectious agents associated with prion diseases such as Creutzfeldt-Jakob disease in humans, bovine spongiform encephalopathy (BSE) in cattle, and…”
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Sulfated Dextrans Enhance In Vitro Amplification of Bovine Spongiform Encephalopathy PrPSc and Enable Ultrasensitive Detection of Bovine PrPSc by Murayama, Yuichi, Yoshioka, Miyako, Masujin, Kentaro, Okada, Hiroyuki, Iwamaru, Yoshifumi, Imamura, Morikazu, Matsuura, Yuichi, Fukuda, Shigeo, Onoe, Sadao, Yokoyama, Takashi, Mohri, Shirou

“…Background Prions, infectious agents associated with prion diseases such as Creutzfeldt-Jakob disease in humans, bovine spongiform encephalopathy (BSE) in…”
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Anti-prion activity of Brilliant Blue G by Iwamaru, Yoshifumi, Takenouchi, Takato, Murayama, Yuichi, Okada, Hiroyuki, Imamura, Morikazu, Shimizu, Yoshihisa, Hashimoto, Makoto, Mohri, Shirou, Yokoyama, Takashi, Kitani, Hiroshi

“…Prion diseases are fatal neurodegenerative disorders with no effective therapy currently available. Accumulating evidence has implicated over-activation of…”
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