Search Results - "IWAMA, Hisakazu"

MicroRNA Expression Profiles in Superficial Esophageal Squamous Cell Carcinoma before Endoscopic Submucosal Dissection: A Pilot Study by Fujihara, Shintaro, Kobara, Hideki, Nishiyama, Noriko, Hirose, Kayo, Iwama, Hisakazu, Masaki, Tsutomu

“…Esophageal squamous cell carcinoma (ESCC) has a poor prognosis when diagnosed at an advanced stage, and early detection and treatment are essential to improve…”
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The antidiabetic drug metformin inhibits gastric cancer cell proliferation in vitro and in vivo by Kato, Kiyohito, Gong, Jian, Iwama, Hisakazu, Kitanaka, Akira, Tani, Joji, Miyoshi, Hisaaki, Nomura, Kei, Mimura, Shima, Kobayashi, Mitsuyoshi, Aritomo, Yuuichi, Kobara, Hideyuki, Mori, Hirohito, Himoto, Takashi, Okano, Keiichi, Suzuki, Yasuyuki, Murao, Koji, Masaki, Tsutomu

“…Recent studies suggest that metformin, which is commonly used as an oral anti-hyperglycemic agent of the biguanide family, may reduce cancer risk and improve…”
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Ipragliflozin attenuates non-alcoholic steatohepatitis development in an animal model by Morishita, Asahiro, Tadokoro, Tomoko, Fujihara, Shintaro, Iwama, Hisakazu, Oura, Kyoko, Fujita, Koji, Tani, Joji, Takuma, Kei, Nakahara, Mai, Shi, Tingting, Haba, Reiji, Okano, Keiichi, Nishiyama, Akira, Ono, Masafumi, Himoto, Takashi, Masaki, Tsutomu

“…Non-alcoholic steatohepatitis (NASH) is a common chronic liver disease with no decisive treatment. The sodium glucose cotransporter 2 (SGLT2) inhibitor…”
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Human microRNAs preferentially target genes with intermediate levels of expression and its formation by mammalian evolution by Iwama, Hisakazu, Kato, Kiyohito, Imachi, Hitomi, Murao, Koji, Masaki, Tsutomu

“…MicroRNAs (miRNAs) are short, endogenous RNAs that post-transcriptionally repress mRNAs. Over the course of evolution, many new miRNAs are known to have…”
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Evaluating the Effect of Lenvatinib on Sorafenib-Resistant Hepatocellular Carcinoma Cells by Shi, Tingting, Iwama, Hisakazu, Fujita, Koji, Kobara, Hideki, Nishiyama, Noriko, Fujihara, Shintaro, Goda, Yasuhiro, Yoneyama, Hirohito, Morishita, Asahiro, Tani, Joji, Yamada, Mari, Nakahara, Mai, Takuma, Kei, Masaki, Tsutomu

“…Hepatocellular carcinoma (HCC) is one of the major causes of cancer-related deaths worldwide. Sorafenib has been used as a first-line systemic treatment for…”
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Telmisartan Inhibits Cell Proliferation and Tumor Growth of Esophageal Squamous Cell Carcinoma by Inducing S-Phase Arrest In Vitro and In Vivo by Matsui, Takanori, Chiyo, Taiga, Kobara, Hideki, Fujihara, Shintaro, Fujita, Koji, Namima, Daisuke, Nakahara, Mai, Kobayashi, Nobuya, Nishiyama, Noriko, Yachida, Tatsuo, Morishita, Asahiro, Iwama, Hisakazu, Masaki, Tsutomu

“…Esophageal squamous cell carcinoma (ESCC) is the most common primary esophageal malignancy. Telmisartan, an angiotensin II type 1 (AT1) receptor blocker (ARB)…”
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Angiotensin II induces cholesterol accumulation and impairs insulin secretion by regulating ABCA1 in beta cells by Lyu, Jingya, Imachi, Hitomi, Fukunaga, Kensaku, Sato, Seisuke, Ibata, Tomohiro, Kobayashi, Toshihiro, Dong, Tao, Yoshimoto, Takuo, Yonezaki, Kazuko, Nagata, Hiromi, Iwama, Hisakazu, Murao, Koji

“…In pancreatic β cells, ABCA1, a 254 kDa membrane protein, affects cholesterol homeostasis and insulin secretion. Angiotensin II, as the main effector of the…”
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Angiotensin receptor blocker telmisartan inhibits cell proliferation and tumor growth of cholangiocarcinoma through cell cycle arrest by Samukawa, Eri, Fujihara, Shintaro, Oura, Kyoko, Iwama, Hisakazu, Yamana, Yoshimi, Tadokoro, Tomoko, Chiyo, Taiga, Kobayashi, Kiyoyuki, Morishita, Asahiro, Nakahara, Mai, Kobara, Hideki, Mori, Hirohito, Okano, Keiichi, Suzuki, Yasuyuki, Himoto, Takashi, Masaki, Tsutomu

“…Cholangiocarcinoma (CCA) is at an advanced stage at the time of its diagnosis, and developing a more effective treatment of CCA would be desirable. Angiotensin…”
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Cancer Therapy Due to Apoptosis: Galectin-9 by Fujita, Koji, Iwama, Hisakazu, Oura, Kyoko, Tadokoro, Tomoko, Samukawa, Eri, Sakamoto, Teppei, Nomura, Takako, Tani, Joji, Yoneyama, Hirohito, Morishita, Asahiro, Himoto, Takashi, Hirashima, Mitsuomi, Masaki, Tsutomu

“…Dysregulation of apoptosis is a major hallmark in cancer biology that might equip tumors with a higher malignant potential and chemoresistance. The anti-cancer…”
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Eicosapentaenoic acid down-regulates expression of the selenoprotein P gene by inhibiting SREBP-1c protein independently of the AMP-activated protein kinase pathway in H4IIEC3 hepatocytes by Tajima-Shirasaki, Natsumi, Ishii, Kiyo-aki, Takayama, Hiroaki, Shirasaki, Takayoshi, Iwama, Hisakazu, Chikamoto, Keita, Saito, Yoshiro, Iwasaki, Yasumasa, Teraguchi, Atsushi, Lan, Fei, Kikuchi, Akihiro, Takeshita, Yumie, Murao, Koji, Matsugo, Seiichi, Kaneko, Shuichi, Misu, Hirofumi, Takamura, Toshinari

“…Selenoprotein P (encoded by SELENOP in humans, Selenop in rat), a liver-derived secretory protein, induces resistance to insulin and vascular endothelial…”
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Human microRNAs originated from two periods at accelerated rates in mammalian evolution by Iwama, Hisakazu, Kato, Kiyohito, Imachi, Hitomi, Murao, Koji, Masaki, Tsutomu

“…MicroRNAs (miRNAs) are short, noncoding RNAs that modulate genes posttranscriptionally. Frequent gains and losses of miRNA genes have been reported to occur…”
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Metformin Inhibits Proliferation and Tumor Growth of QGP-1 Pancreatic Neuroendocrine Tumor Cells by Inducing Cell Cycle Arrest and Apoptosis by Yamana, Hiroki, Kato, Kiyohito, Kobara, Hideki, Fujihara, Shintaro, Fujita, Koji, Namima, Daisuke, Fujita, Naoki, Kobayashi, Kiyoyuki, Kamada, Hideki, Morishita, Asahiro, Tsutsui, Kunihiko, Iwama, Hisakazu, Masaki, Tsutomu

“…Pancreatic neuroendocrine tumors (pNETs) are rare pancreatic neoplasms, and therapeutic options for pNETs are limited. Metformin is an anti-hypoglycemic drug…”
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Metformin Suppresses Expression of the Selenoprotein P Gene via an AMP-activated Kinase (AMPK)/FoxO3a Pathway in H4IIEC3 Hepatocytes by Takayama, Hiroaki, Misu, Hirofumi, Iwama, Hisakazu, Chikamoto, Keita, Saito, Yoshiro, Murao, Koji, Teraguchi, Atsushi, Lan, Fei, Kikuchi, Akihiro, Saito, Reina, Tajima, Natsumi, Shirasaki, Takayoshi, Matsugo, Seiichi, Miyamoto, Ken-ichi, Kaneko, Shuichi, Takamura, Toshinari

“…Selenoprotein P (SeP; encoded by SEPP1 in humans) is a liver-derived secretory protein that induces insulin resistance in type 2 diabetes. Suppression of SeP…”
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Light exercise without lactate elevation induces ischemic tolerance through the modulation of microRNA in the gerbil hippocampus by Takata, Tadayuki, Nonaka, Wakako, Iwama, Hisakazu, Kobara, Hideki, Deguchi, Kazushi, Masugata, Hisashi, Touge, Tetsuo, Miyamoto, Osamu, Nakamura, Takehiro, Itano, Toshifumi, Masaki, Tsutomu

“…•Exercise without lactate elevation suppressed ischemia-induced CA1 neuron loss.•Light exercise maintained short-term memory after ischemia.•Expression of 20…”
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Dopamine receptor genes and evolutionary differentiation in the domestication of fighting cocks and long-crowing chickens by Komiyama, Tomoyoshi, Iwama, Hisakazu, Osada, Naoki, Nakamura, Yoji, Kobayashi, Hiroyuki, Tateno, Yoshio, Gojobori, Takashi

“…The chicken domestication process represents a typical model of artificial selection, and gives significant insight into the general understanding of the…”
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Galectin-9 Induces Mitochondria-Mediated Apoptosis of Esophageal Cancer In Vitro and In Vivo in a Xenograft Mouse Model by Chiyo, Taiga, Fujita, Koji, Iwama, Hisakazu, Fujihara, Shintaro, Tadokoro, Tomoko, Ohura, Kyoko, Matsui, Takanori, Goda, Yasuhiro, Kobayashi, Nobuya, Nishiyama, Noriko, Yachida, Tatsuo, Morishita, Asahiro, Kobara, Hideki, Mori, Hirohito, Niki, Toshiro, Hirashima, Mitsuomi, Himoto, Takashi, Masaki, Tsutomu

“…Galectin-9 (Gal-9) enhances tumor immunity mediated by T cells, macrophages, and dendritic cells. Its expression level in various cancers correlates with…”
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Antitumor Effect of Regorafenib on MicroRNA Expression in Hepatocellular Carcinoma Cell Lines by Takuma, Kei, Fujihara, Shintaro, Fujita, Koji, Iwama, Hisakazu, Nakahara, Mai, Oura, Kyoko, Tadokoro, Tomoko, Mimura, Shima, Tani, Joji, Shi, Tingting, Morishita, Asahiro, Kobara, Hideki, Himoto, Takashi, Masaki, Tsutomu

“…Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver and is one of the leading causes of cancer-related deaths worldwide…”
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Telmisartan inhibits hepatocellular carcinoma cell proliferation in vitro by inducing cell cycle arrest by Oura, Kyoko, Tadokoro, Tomoko, Fujihara, Shintaro, Morishita, Asahiro, Chiyo, Taiga, Samukawa, Eri, Yamana, Yoshimi, Fujita, Koji, Sakamoto, Teppei, Nomura, Takako, Yoneyama, Hirohito, Kobara, Hideki, Mori, Hirohito, Iwama, Hisakazu, Okano, Keiichi, Suzuki, Yasuyuki, Masaki, Tsutomu

“…Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver and the third leading cause of cancer-related death. Telmisartan, a widely…”
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Oxidized LDL Downregulates ABCA1 Expression via MEK/ERK/LXR Pathway in INS-1 Cells by Lyu, Jingya, Fukunaga, Kensaku, Imachi, Hitomi, Sato, Seisuke, Kobayashi, Toshihiro, Saheki, Takanobu, Ibata, Tomohiro, Yoshimura, Takafumi, Iwama, Hisakazu, Murao, Koji

“…Impaired insulin secretion is one of the main causes of type 2 diabetes. Cholesterol accumulation-induced lipotoxicity contributes to impaired insulin…”
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Effect of the anti-diabetic drug metformin in hepatocellular carcinoma in vitro and in vivo by MIYOSHI, HISAAKI, KATO, KIYOHITO, IWAMA, HISAKAZU, MAEDA, EMIKO, SAKAMOTO, TEPPEI, FUJITA, KOJI, TOYOTA, YUKA, TANI, JOJI, NOMURA, TAKAKO, MIMURA, SHIMA, KOBAYASHI, MITSUYOSHI, MORISHITA, ASAHIRO, KOBARA, HIDEKI, MORI, HIROHITO, YONEYAMA, HIROHITO, DEGUCHI, AKIHIRO, HIMOTO, TAKASHI, KUROKOHCHI, KAZUTAKA, OKANO, KEIICHI, SUZUKI, YASUYUKI, MURAO, KOJI, MASAKI, TSUTOMU

“…Metformin is a commonly used oral anti-hyperglycemic agent of the biguanide family. Recent studies suggest that metformin may reduce cancer risk and improve…”
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